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Canine Cancer Detection
Canine cancer detection is an approach to cancer screening that relies upon the claimed olfactory ability of dogs to detect, in urine or in breath, very low concentrations of the alkanes and aromatic compounds generated by malignant tumors. While some research has been promising, no verified studies by secondary research groups have substantiated the validity of positive, conclusive results. Background Media coverage The proposal that dogs can detect cancer attracted widespread coverage in the general media. In 2015 the Huffington Post reported that studies have suggested that dogs may be able to detect lung cancer, melanoma, breast cancer and bladder cancer, and that dogs can be trained to detect cancer in 93% of cases. In 2016, actress Shannen Doherty told ''Entertainment Tonight'' in an interview that her dog identified her breast cancer before doctors could diagnose it. ''National Geographic'' said that "man's best friend can detect various cancers, including prostate can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Screening
Cancer screening aims to detect cancer before symptoms appear. This may involve blood tests, urine tests, DNA tests, other tests, or medical imaging. The benefits of screening in terms of cancer prevention, early detection and subsequent treatment must be weighed against any harms. Universal screening, also known as mass screening or population screening, involves screening everyone, usually within a specific age group. Selective screening identifies people who are known to be at higher risk of developing cancer, such as people with a family history of cancer. Screening can lead to false positive results and subsequent invasive procedures. Screening can also lead to false negative results, where an existing cancer is missed. Controversy arises when it is not clear if the benefits of screening outweigh the risks of the screening procedure itself, and any follow-up diagnostic tests and treatments. Screening tests must be effective, safe, well tolerated with acceptably low rates of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sensitivity And Specificity
''Sensitivity'' and ''specificity'' mathematically describe the accuracy of a test which reports the presence or absence of a condition. Individuals for which the condition is satisfied are considered "positive" and those for which it is not are considered "negative". *Sensitivity (true positive rate) refers to the probability of a positive test, conditioned on truly being positive. *Specificity (true negative rate) refers to the probability of a negative test, conditioned on truly being negative. If the true condition can not be known, a " gold standard test" is assumed to be correct. In a diagnostic test, sensitivity is a measure of how well a test can identify true positives and specificity is a measure of how well a test can identify true negatives. For all testing, both diagnostic and screening, there is usually a trade-off between sensitivity and specificity, such that higher sensitivities will mean lower specificities and vice versa. If the goal is to return the ratio at w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncology
Oncology is a branch of medicine that deals with the study, treatment, diagnosis and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's etymological origin is the Greek word ὄγκος (''ónkos''), meaning "tumor", "volume" or "mass". Oncology is concerned with: * The diagnosis of any cancer in a person (pathology) * Therapy (e.g. surgery, chemotherapy, radiotherapy and other modalities) * Follow-up of cancer patients after successful treatment * Palliative care of patients with terminal malignancies * Ethical questions surrounding cancer care * Screening efforts: ** of populations, or ** of the relatives of patients (in types of cancer that are thought to have a hereditary basis, such as breast cancer) Diagnosis Medical histories remain an important screening tool: the character of the complaints and nonspecific symptoms (such as fatigue, weight loss, unexplained anemia, fever of unknown origin, paraneoplasti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Working Dogs
A working dog is a dog used to perform practical tasks, as opposed to pet or companion dogs. Definitions vary on what a working dog is, they are sometimes described as any dog trained for and employed in meaningful work; other times as any dog whose breed heritage or physical characteristics lend itself to working irrespective of an individual animal's training or employment; and other times again it is used as a synonym for herding dog. Working dog types Roles performed by dogs that sometimes sees them classified as working dogs include: * Assistance dog trained to help a disabled person in some way, such as guiding a visually impaired person, opening doors or alerting to a ringing phone. * Carriage dog historically used to provide protection to carriage passengers or merchandise * Detection dog or sniffer dog, trained to detect for example drugs or land mines. * Draught dog traditionally used to pull dog carts * Guard dog used to protect buildings or livestock * Guide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scent Hound
Franz Rudolf Frisching in the uniform of an officer of the Bernese Huntsmen Corps with his Berner Laufhund, painted by Jean Preudhomme in 1785 Scent hounds (or scenthounds) are a Dog type, type of hound that primarily hunts by scent rather than visual perception, sight. These breeds are hunting dogs and are generally regarded as having some of the most sensitive noses among dogs. Scent hounds specialize in following scent or smells. Most of them tend to have long, drooping ears and large nasal cavities to enhance smell sensitivity. They relatively need to have high endurance to be able to keep track of scent over long distances and rough terrain. It is believed that they were originally bred by the Celts. Description Hounds are hunting dogs that either hunt by following the scent of a game animal (''scent hounds'') or by following the animal by sight (sighthounds). There are many breeds in the ''scent hound type'', and scent hounds may do other work as well, so exactly whic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Efficacy
Efficacy is the ability to perform a task to a satisfactory or expected degree. The word comes from the same roots as ''effectiveness'', and it has often been used synonymously, although in pharmacology a distinction is now often made between efficacy and effectiveness. The word ''efficacy'' is used in pharmacology and medicine to refer both to the maximum response achievable from a pharmaceutical drug in research settings, and to the capacity for sufficient therapeutic effect or beneficial change in clinical settings. Pharmacology In pharmacology, efficacy () is the maximum response achievable from an applied or dosed agent, for instance, a small molecule drug. Intrinsic activity is a relative term for a drug's efficacy relative to a drug with the highest observed efficacy. It is a purely descriptive term that has little or no mechanistic interpretation. In order for a drug to have an effect, it needs to bind to its target, and then to affect the function of this target. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistics
Statistics (from German: '' Statistik'', "description of a state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of surveys and experiments.Dodge, Y. (2006) ''The Oxford Dictionary of Statistical Terms'', Oxford University Press. When census data cannot be collected, statisticians collect data by developing specific experiment designs and survey samples. Representative sampling assures that inferences and conclusions can reasonably extend from the sample to the population as a whole. An ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Confounding Factors
In statistics, a confounder (also confounding variable, confounding factor, extraneous determinant or lurking variable) is a variable that influences both the dependent variable and independent variable, causing a spurious association. Confounding is a causal concept, and as such, cannot be described in terms of correlations or associations.Pearl, J., (2009). Simpson's Paradox, Confounding, and Collapsibility In ''Causality: Models, Reasoning and Inference'' (2nd ed.). New York : Cambridge University Press. The existence of confounders is an important quantitative explanation why correlation does not imply causation. Confounds are threats to internal validity. Definition Confounding is defined in terms of the data generating model. Let ''X'' be some independent variable, and ''Y'' some dependent variable. To estimate the effect of ''X'' on ''Y'', the statistician must suppress the effects of extraneous variables that influence both ''X'' and ''Y''. We say that ''X'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Volatile Organic Compound
Volatile organic compounds (VOCs) are organic compounds that have a high vapour pressure at room temperature. High vapor pressure correlates with a low boiling point, which relates to the number of the sample's molecules in the surrounding air, a trait known as volatility. VOCs are responsible for the odor of scents and perfumes as well as pollutants. VOCs play an important role in communication between animals and plants, e.g. attractants for pollinators, protection from predation, and even inter-plant interactions. Some VOCs are dangerous to human health or cause harm to the environment. Anthropogenic VOCs are regulated by law, especially indoors, where concentrations are the highest. Most VOCs are not acutely toxic, but may have long-term chronic health effects. Definitions Diverse definitions of the term VOC are in use. Canada Health Canada classifies VOCs as organic compounds that have boiling points roughly in the range of . The emphasis is placed on commonly encountere ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pilot Experiment
A pilot study, pilot project, pilot test, or pilot experiment is a small-scale preliminary study conducted to evaluate feasibility, duration, cost, adverse events, and improve upon the study design prior to performance of a full-scale research project. Implementation Pilot experiments are frequently carried out before large-scale quantitative research, in an attempt to avoid time and money being used on an inadequately designed project. A pilot study is usually carried out on members of the relevant population. A pilot study is used to formulate the design of the full-scale experiment which then can be adjusted. The pilot study is potentially a critical insight to clinical trial design, recruitment and sample size of participants, treatment testing, and statistical analysis to improve the power of testing the hypothesis of the study. Analysis from the pilot experiment can be added to the full-scale (and more expensive) experiment to improve the chances of a clear outcome. Appl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anecdotes
An anecdote is "a story with a point", such as to communicate an abstract idea about a person, place, or thing through the concrete details of a short narrative or to characterize by delineating a specific quirk or trait. Occasionally humorous, anecdotes differ from jokes because their primary purpose is not simply to provoke laughter but to reveal a truth more general than the brief tale itself. Anecdotes may be real or fictional; the anecdotal digression is a common feature of literary works and even oral anecdotes typically involve subtle exaggeration and dramatic shape designed to entertain the listener. An anecdote is always presented as the recounting of a real incident involving actual people and usually in an identifiable place. In the words of Jürgen Hein, they exhibit "a special realism" and "a claimed historical dimension" . Etymology and usage The word ''anecdote'' (in Greek: ἀνέκδοτον "unpublished", literally "not given out") comes from Procopius of C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Literature
: ''For a broader class of literature, see Academic publishing.'' Scientific literature comprises scholarly publications that report original empirical and theoretical work in the natural and social sciences. Within an academic field, scientific literature is often referred to as the literature. Academic publishing is the process of contributing the results of one's research into the literature, which often requires a peer-review process. Original scientific research published for the first time in scientific journals is called the primary literature. Patents and technical reports, for minor research results and engineering and design work (including computer software), can also be considered primary literature. Secondary sources include review articles (which summarize the findings of published studies to highlight advances and new lines of research) and books (for large projects or broad arguments, including compilations of articles). Tertiary sources might include ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
