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Canadian Centre For Alternatives To Animal Methods
The Canadian Centre for Alternatives to Animal Methods (CCAAM) and its subsidiary, the Canadian Centre for the Validation of Alternative Methods (CaCVAM), is a research centre founded in 2017 and based at the University of Windsor, in Canada. Its goal is “to develop, validate, and promote laboratory methods and techniques that don’t use animal test subjects”. It is the first centre in Canada dedicated to non-animal testing and the promotion of human-relevant alternatives. Mission and projects The CCAAM's mission is based on three pillars: * scientific research relying exclusively on human-based biomaterials and human biology-based methodologies, including human cells, stem cells, tissues from cadavers, biopsies, and explanted organs from surgeries; * academic training for scientists, ethicists, regulators, and policy makers, including development of a one-year masters programme; * regulatory initiatives for changing chemical safety methods in Canada, with academic, industry ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alternatives To Animal Testing
Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. There is widespread agreement that a reduction in the number of animals used and the refinement of testing to reduce suffering should be important goals for the industries involved. Two major alternatives to ''in vivo'' animal testing are ''in vitro'' cell culture techniques and ''in silico'' computer simulation. However, some claim they are not true alternatives because simulations use data from prior animal experiments and cell cultures often require animal derived products, such as blood plasma, serum or cells. Others say that they cannot replace animals completely as they are unlikely to ever provide enough information about the complex interactions of living systems. Other alternatives include the use of humans for skin irritancy tests and donated human blood for pyrogenicity studies. Another alternative is so-called microdosing, in which the basic behavio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heart Disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, abnormal heart rhythms, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis. The underlying mechanisms vary depending on the disease. It is estimated that dietary risk factors are associated with 53% of CVD deaths. Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis. This may be caused by high blood pressure, smoking, diabetes mellitus, lack of exercise, obesity, high blood cholesterol, poor diet, excessive alcohol consumption, and poor sleep, among other things. High blood pressure is estimated to account for approximatel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laboratory Techniques
A laboratory (; ; colloquially lab) is a facility that provides controlled conditions in which scientific or technological research, experiments, and measurement may be performed. Laboratory services are provided in a variety of settings: physicians' offices, clinics, hospitals, and regional and national referral centers. Overview The organisation and contents of laboratories are determined by the differing requirements of the specialists working within. A physics laboratory might contain a particle accelerator or vacuum chamber, while a metallurgy laboratory could have apparatus for casting or refining metals or for testing their strength. A chemist or biologist might use a wet laboratory, while a psychologist's laboratory might be a room with one-way mirrors and hidden cameras in which to observe behavior. In some laboratories, such as those commonly used by computer scientists, computers (sometimes supercomputers) are used for either simulations or the analysis of data. Scienti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Testing Techniques
Animals are multicellular, eukaryotic organisms in the biological kingdom Animalia. With few exceptions, animals consume organic material, breathe oxygen, are able to move, can reproduce sexually, and go through an ontogenetic stage in which their body consists of a hollow sphere of cells, the blastula, during embryonic development. Over 1.5 million living animal species have been described—of which around 1 million are insects—but it has been estimated there are over 7 million animal species in total. Animals range in length from to . They have complex interactions with each other and their environments, forming intricate food webs. The scientific study of animals is known as zoology. Most living animal species are in Bilateria, a clade whose members have a bilaterally symmetric body plan. The Bilateria include the protostomes, containing animals such as nematodes, arthropods, flatworms, annelids and molluscs, and the deuterostomes, containing the echino ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Testing Regulations
Animal testing regulations are guidelines that permit and control the use of non-human animals for scientific experimentation. They vary greatly around the world, but most governments aim to control the number of times individual animals may be used; the overall numbers used; and the degree of pain that may be inflicted without anesthetic. Europe Experiments on vertebrate animals in the European Union are since January 1, 2013. subject to '' Directive 2010/63/EU on the protection of animals used for scientific purposes'', which was finalized in November 2010 and updated and replaced the ''Directive 86/609/EEC on the protection of Animals used for Experimental and other scientific purposes'', adopted in 1986."Directive 86/609/EEC on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pain And Suffering In Laboratory Animals
Pain negatively affects the health and welfare of animals. "Pain" is defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." Only the animal experiencing the pain can know the pain's quality and intensity, and the degree of suffering. It is harder, if even possible, for an observer to know whether an emotional experience has occurred, especially if the sufferer cannot communicate. Therefore, this concept is often excluded in definitions of pain in animals, such as that provided by Zimmerman: "an aversive sensory experience caused by actual or potential injury that elicits protective motor and vegetative reactions, results in learned avoidance and may modify species-specific behaviour, including social behaviour." Nonhuman animals cannot report their feelings to language-using humans in the same manner as human communication, but ob ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Center For Alternatives To Animal Testing
The Johns Hopkins University Center for Alternatives to Animal Testing (CAAT) has worked with scientists, since 1981, to find new methods to replace the use of laboratory animals in experiments, reduce the number of animals tested, and refine necessary tests to eliminate pain and distress (the Three Rs as described in Russell and Burch's ''Principles of Humane Experimental Technique''). CAAT is an academic, science-based center affiliated with the Johns Hopkins Bloomberg School of Public Health. CAAT promotes humane science by supporting the creation, development, validation, and use of alternatives to animals in research, product safety testing, and education. It is not an activist group; rather, it seeks to effect change by working with scientists in industry, government, and academia to find new ways to replace animals with non-animal methods, reduce the numbers of animals necessary, or refine methods to make them less painful or stressful to the animals involved. CAAT has offe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trials
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charu Chandrasekera
Charu is a word derived from Sanskrit that refers to something beautiful, graceful and pure in a spiritual sense. The word also means “one who is radiant and graceful” And is often used in the Ramayana for praising Lord Rama. It refers to the kind of beauty that is out of this materialistic world and often refers to celestial bodies such as the full moon. In a popular Hindi poem, ''charu'' is used to describe the beauty of the moon-''Charu chandra ki chanchal kirne khel rahi thi jal-thal mein''.According tGoogle Translate this poem means: "Charun Chandra's playful rays were playing in the water" As a name Charu is a popular name given to Hindu males and females and means divinely good looking and charming. Notable people with the name Charu include: * Charu Majumdar: The founder of Naxalbari Andolan in India * Charulata: Eponymous protagonist of Satyajit Ray's movie * Charu space: a Tibetan style coffee shop and event center in Chengdu Other meanings In Sanskrit, c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Windsor, Ontario
Windsor is a city in southwestern Ontario, Canada, on the south bank of the Detroit River directly across from Detroit, Michigan, United States. Geographically located within but administratively independent of Essex County, it is the southernmost city in Canada and marks the southwestern end of the Quebec City–Windsor Corridor. The city's population was 229,660 at the 2021 census, making it the third-most populated city in Southwestern Ontario, after London and Kitchener. The Detroit–Windsor urban area is North America's most populous trans-border conurbation, and the Ambassador Bridge border crossing is the busiest commercial crossing on the Canada–United States border. Windsor is a major contributor to Canada's automotive industry and is culturally diverse. Known as the "Automotive Capital of Canada", Windsor's industrial and manufacturing heritage is responsible for how the city has developed through the years. History Early settlement At the time when the fir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased appetite. If left untreated, diabetes can cause many health complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death. Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes, and cognitive impairment. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. Insulin is a hormone which is responsible for helping glucose from food get into cells to be used for energy. There are three main types of diabetes mellitus: * Type 1 diabetes results from failure of the pancreas to produce enough insulin due to lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biopsies
A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist. The process involves extraction of sample cells or tissues for examination to determine the presence or extent of a disease. The tissue is then fixed, dehydrated, embedded, sectioned, stained and mounted before it is generally examined under a microscope by a pathologist; it may also be analyzed chemically. When an entire lump or suspicious area is removed, the procedure is called an excisional biopsy. An incisional biopsy or core biopsy samples a portion of the abnormal tissue without attempting to remove the entire lesion or tumor. When a sample of tissue or fluid is removed with a needle in such a way that cells are removed without preserving the histological architecture of the tissue cells, the procedure is called a needle aspiration biopsy. Biopsies are most commonly performed for insight into possible cancerous or inflammatory conditions. History T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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