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CD85
The term "CD85" was originally used to refer to LILR1 which is now known as LILRB1, CD85j; however, there are a number of CD85 genes: {{cite book , last = Carrington , first = M , authorlink = , author2=Norman, P , title = The KIR Gene Cluster (e-book) , publisher = NCBI Bookshelf , year = 2003 , location = , pages = , url = https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mono_003∂=A1 , doi = , id = , isbn = ''LILR: leukocyte immunoglobulin-like receptor; ILT: immunoglobulin-like transcript; LIR: leukocyte inhibitory receptor; MIR: macrophage inhibitory receptor.'' References [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LILR1
Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the ''LILRB1'' gene. Function This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. See also * Cluster of differentiation References Further r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LILRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the ''LILRB1'' gene. Function This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. See also * Cluster of differentiation The cluster of different ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LILRA3
Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the ''LILRA3'' gene located within the leukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown; however, it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease. Like the closely related LILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HL ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LILRA2
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the ''LILRA2'' gene. Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor. upplied by OMIMref name="entrez"> Function LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells. See also * Cluster of differentiation The cluster of differentiation (also known as cluster of designation or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ILT10
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the ''LILRA2'' gene. Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor. upplied by OMIMref name="entrez"> Function LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells. See also * Cluster of differentiation References Further reading * * * * * * * * External links * PDB ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LILRA1
Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 is a protein that in humans is encoded by the ''LILRA1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b .... References Further reading * * * * * * * * * {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LILRA4
Leukocyte immunoglobulin-like receptor subfamily A member 4 is a protein that in humans is encoded by the ''LILRA4'' gene. This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains. They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells.Damian ... gene cluster (LRC) at chromosomal region 19q13.4. References Further reading * * * * * * * * * {{refend Immunoglobulin superfamily ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LILRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the ''LILRB2'' gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. LILBR2 plays a critical role in the inhibition of axonal regeneration and fun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LILRB3
Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the ''LILRB3'' gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells and is believed to be a myeloid checkpoint. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. See also * Cluster of differentiation The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol us ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LILRB5
Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the ''LILRB5'' gene. This gene is a member of the leukocyte immunoglobulin-like receptor The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains. They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells.Damia ... (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding differ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |