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Alpha-1 Blockers
Alpha 1 or Alpha-1 may refer to: *Alpha-1 adrenergic receptor, a G protein-coupled receptor *Alpha-1 antitrypsin, a protein **Alpha-1 antitrypsin deficiency, a genetic disorder *Alpha-1-fetoprotein or Alpha-fetoprotein, a protein *Alpha-One, a fictional spacecraft in '' Buzz Lightyear of Star Command: The Adventure Begins'' * ''Alpha 1'' (Robert Silverberg anthology), a 1970 book See also * * *Alpha (other) *AMY1A Alpha-amylase 1 is an enzyme that in humans is encoded by the ''AMY1A'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth' ... or Alpha-1A or, an enzyme found in humans and other mammals * List of A1 genes, proteins or receptors {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1 Adrenergic Receptor
alpha-1 (α1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the Gq heterotrimeric G protein. α1-adrenergic receptors are subdivided into three highly homologous subtypes, i.e., α1A-, α1B-, and α1D-adrenergic receptor subtypes. There is no α1C receptor. At one time, there was a subtype known as α1C, but it was found to be identical to the previously discovered α1A receptor subtype. To avoid confusion, naming was continued with the letter D. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α1-adrenergic receptors in the central and peripheral nervous systems. The crystal structure of the α1B-adrenergic receptor subtype has been determined in complex with the inverse agonist (+)-cyclazosin. Effects The α1-adrenergic receptor has several general functions in common with the α2-adrenergic receptor, but also has specific effects of its own. α1-receptors primarily mediate smooth muscle cont ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1 Antitrypsin
Alpha-1 antitrypsin or α1-antitrypsin (A1AT, α1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the ''SERPINA1'' gene. A protease inhibitor, it is also known as alpha1–proteinase inhibitor (A1PI) or alpha1-antiproteinase (A1AP) because it inhibits various proteases (not just trypsin). In older biomedical literature it was sometimes called serum trypsin inhibitor (STI, dated terminology), because its capability as a trypsin inhibitor was a salient feature of its early study. As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 0.9–2.3 g/L (in the US the reference range is expressed as mg/dL or micromoles), but the concentration can rise manyfold upon acute inflammation. When the blood contains inadequate amounts of A1AT or functionally defective A1AT (such as in alpha-1 antitrypsin deficiency), neutrophil elastase is excessi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1 Antitrypsin Deficiency
Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. Onset of lung problems is typically between 20 and 50 years of age. This may result in shortness of breath, wheezing, or an increased risk of lung infections. Complications may include chronic obstructive pulmonary disease (COPD), cirrhosis, neonatal jaundice, or panniculitis. A1AD is due to a mutation in the SERPINA1 gene that results in not enough alpha-1 antitrypsin (A1AT). Risk factors for lung disease include tobacco smoking and environmental dust. The underlying mechanism involves unblocked neutrophil elastase and buildup of abnormal A1AT in the liver. It is autosomal co-dominant, meaning that one defective allele tends to result in milder disease than two defective alleles. The diagnosis is suspected based on symptoms and confirmed by blood tests or genetic tests. Treatment of lung disease may include bronchodilators, inhaled steroids, and, when infect ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1-fetoprotein
Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein, alpha-fetoglobulin, or alpha fetal protein) is a protein that in humans is encoded by the ''AFP'' gene. The ''AFP'' gene is located on the ''q'' arm of chromosome 4 (4q25). Maternal AFP serum level is used to screen for Down syndrome, neural tube defects, and other chromosomal abnormalities. AFP is a major plasma protein produced by the yolk sac and the fetal liver during fetal development. It is thought to be the fetal analog of serum albumin. AFP binds to copper, nickel, fatty acids and bilirubin and is found in monomeric, dimeric and trimeric forms. Structure AFP is a glycoprotein of 591 amino acids and a carbohydrate moiety. Function The function of AFP in adult humans is unknown. AFP is the most abundant plasma protein found in the human fetus. Maternal plasma levels peak near the end of the first trimester, and begin decreasing prenatally at that time, then decrease rapidly after birt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Adventure Begins
''Greyhawk: The Adventure Begins'' is a 1998 sourcebook for the ''World of Greyhawk'' campaign setting for the ''Dungeons & Dragons'' roleplaying game. The 128 page book was written by Roger E. Moore and published by Wizards of the Coast under the TSR imprint it had recently acquired. Contents ''The Adventure Begins'' contains a general overview of the world of Oerth, including updates on the world's history, notable calendar events, and descriptions of the cultural and geographical divisions of the area. The book provides much specific information on the City of Greyhawk, the largest and most populous city of Oerth, including details on everything from its ruling council to its criminal codes, and descriptions of notable locations and characters within the city. Publication history ''The Adventure Begins'' was intended as a "bridge" between previous Greyhawk products, and the relaunch of the new product line. The book updates material from the earlier '' From the Ashes''. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha 1 (Robert Silverberg Anthology)
''Alpha 1'' is a science fiction anthology edited by Robert Silverberg first published in 1970. Stories in ''Alpha 1'' *Introduction by Robert Silverberg *''Poor Little Warrior'' by Brian W. Aldiss *''The Moon Moth'' by Jack Vance *''Testament of Andros'' by James Blish *''A Triptych'' by Barry N. Malzberg *''For a Breath I Tarry'' by Roger Zelazny *''Game for Motel Room'' by Fritz Leiber *''Thus We Frustrate Charlemagne'' by R. A. Lafferty *''The Man Who Came Early'' by Poul Anderson *''The Time of His Life'' by Larry Eisenberg *''The Doctor'' by Ted Thomas *''Time Trap'' by Charles L. Harness *''The Pi Man'' by Alfred Bester *''The Last Man Left in the Bar'' by C. M. Kornbluth *''The Terminal Beach'' by J. G. Ballard James Graham Ballard (15 November 193019 April 2009) was an English novelist, short story writer, satirist, and essayist known for provocative works of fiction which explored the relations between human psychology, technology, sex, and mass medi ... References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha (other)
Alpha ( or ) is the first letter of the Greek alphabet. Alpha or ALPHA may also refer to: Letters * Latin alpha (), a letter of the Latin alphabet * , a glyph in the International Phonetic Alphabet * , a vowel in the General Alphabet of Cameroon Languages * Alfa, the first letter in the NATO phonetic alphabet Art and entertainment Books and comics * ''Alpha'' (Lombard), a Franco-Belgian comics series * ''The Alphas'', a young-adult novel series by Lisi Harrison * ''Alpha 1'' through ''Alpha 9'', anthologies edited by Robert Silverberg Film and TV * ''Alpha'' (2018 film), an American film starring Kodi Smit-McPhee * ''Alpha'' (2019 film), a Bangladeshi film * ''Alphas'', an American science fiction TV series 2011–2012 * "Alpha" (''The X-Files''), a sixth-season episode of ''The X-Files'' * ''Alpha'' and ''Omega'' (radio plays) Fictional characters and places * Alpha (DC Comics), a character from DC Comics * Alpha (Marvel Comics), a character from Marvel Comics * Alpha ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AMY1A
Alpha-amylase 1 is an enzyme that in humans is encoded by the ''AMY1A'' gene. This gene is found in many organisms. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. See also * AMY2A Pancreatic alpha-amylase is an enzyme that in humans is encoded by the ''AMY2A'' gene. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion ... * References External links * * Further reading * * * * * * * * * * * * * * * * * * * * {{enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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