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C-521T
In genetics, rs1800955 (also written as C-521T and -521C/T) is a single nucleotide polymorphism (SNP). It is located in the promoter region of the ''DRD4'' gene. This gene codes for the dopamine receptor D4. Due to the dopamine hypothesis of schizophrenia the SNP has been investigated for link to schizophrenia, and it may be slightly associated with this disorder. The SNP has been investigated with respect to novelty seeking, — a personality trait that may be measured with the Temperament and Character Inventory. A 2008 meta-analysis A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting me ... indicates a possible association between novelty seeking and C-521T though rather small. References Other Table 4from "The analysis of 51 genes in DSM-IV combined type attention deficit hype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DRD4
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5. The structure of DRD4 was recently reported in complex with the antipsychotic drug nemonapride. As with other dopamine receptor subtypes, the D4 receptor is activated by the neurotransmitter dopamine. It is linked to many neurological and psychiatric conditions including schizophrenia and bipolar disorder, ADHD, addictive behaviors, Parkinson's disease, and eating disorders such as anorexia nervosa. A weak association has been drawn between DRD4 and borderline personality disorder. It is also a target for drugs which treat schizophrenia and Parkinson's disease. The D4 receptor is considered to be D2-like in which the activated receptor inhibits the enzyme adenylate cyclase, thereby reducing the intracellular concentration of the second messenger cyclic AMP. Genetics The human protein is coded by the ''DRD4'' on chromosome 11 located in 11p15.5. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Temperament And Character Inventory
The Temperament and Character Inventory (TCI) is an inventory for personality traits devised by Cloninger et al. It is closely related to and an outgrowth of the Tridimensional Personality Questionnaire (TPQ), and it has also been related to the dimensions of personality in Zuckerman's alternative five and Eysenck's models and those of the five factor model. TCI operates with seven dimensions of personality traits: four so-called ''temperaments'' * Novelty Seeking (NS) * Harm Avoidance (HA) * Reward Dependence (RD) * Persistence (PS) and three so-called ''characters'' * Self-Directedness (SD) * Cooperativeness (CO) * Self-Transcendence (ST) Each of these traits has a varying number of subscales. The dimensions are determined from a 240-item questionnaire. The TCI is based on a psychobiological model that attempts to explain the underlying causes of individual differences in personality traits. Versions Originally developed in English, TCI has been translated to other langu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jonathan Flint (scientist)
Jonathan Flint is a British behavior geneticist and Professor in Residence in the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine at UCLA. He is also a senior scientist in the Center for Neurobehavioral Genetics at UCLA's Semel Institute for Neuroscience and Human Behavior. Career and research Flint is known for his research on the genetics of complex traits in mice and major depressive disorder in humans. In 2015, he and his colleagues published a study that was the first to link two genetic variants to this disorder. In 2016, he left his post as director of the Psychiatric Genetics Group at the University of Oxford's Wellcome Trust Centre for Human Genetics to join UCLA. Upon doing so, he became one of four directors of UCLA's Depression Grand Challenge, which aims to conduct a study of 100,000 people to search for genetic risk factors for depression. This study is intended to be the largest genetic study of a disorder ever conducted ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saffron A
Saffron () is a spice derived from the flower of ''Crocus sativus'', commonly known as the "saffron crocus". The vivid crimson stigma and styles, called threads, are collected and dried for use mainly as a seasoning and colouring agent in food. Although some doubts remain on its origin, it is believed that saffron originated in Iran. However, Greece and Mesopotamia have also been suggested as the possible region of origin of this plant. Saffron crocus slowly propagated throughout much of Eurasia and was later brought to parts of North Africa, North America, and Oceania. Saffron's taste and iodoform-like or hay-like fragrance result from the phytochemicals picrocrocin and safranal. It also contains a carotenoid pigment, crocin, which imparts a rich golden-yellow hue to dishes and textiles. History of saffron, Its recorded history is attested in a 7th-century BC Assyrian botanical treatise, and has been Trade and use of saffron, traded and used for thousands of years. In the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marcus R
Marcus, Markus, Márkus or Mărcuș may refer to: * Marcus (name), a masculine given name * Marcus (praenomen), a Roman personal name Places * Marcus, a main belt asteroid, also known as (369088) Marcus 2008 GG44 * Mărcuş, a village in Dobârlău Commune, Covasna County, Romania * Marcus, Illinois, an unincorporated community * Marcus, Iowa, a city * Marcus, South Dakota, an unincorporated community * Marcus, Washington, a town * Marcus Island, Japan, also known as Minami-Tori-shima * Mărcuș River, Romania * Marcus Township, Cherokee County, Iowa Other uses * Markus, a beetle genus in family Cantharidae * ''Marcus'' (album), 2008 album by Marcus Miller * Marcus (comedian), finalist on ''Last Comic Standing'' season 6 * Marcus Amphitheater, Milwaukee, Wisconsin * Marcus Center, Milwaukee, Wisconsin * Marcus & Co., American jewelry retailer * Marcus by Goldman Sachs, an online bank * USS ''Marcus'' (DD-321), a US Navy destroyer (1919-1935) See also * Marcos (disambiguat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meta-analysis
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting measurements that are expected to have some degree of error. The aim then is to use approaches from statistics to derive a pooled estimate closest to the unknown common truth based on how this error is perceived. Meta-analytic results are considered the most trustworthy source of evidence by the evidence-based medicine literature.Herrera Ortiz AF., Cadavid Camacho E, Cubillos Rojas J, Cadavid Camacho T, Zoe Guevara S, Tatiana Rincón Cuenca N, Vásquez Perdomo A, Del Castillo Herazo V, & Giraldo Malo R. A Practical Guide to Perform a Systematic Literature Review and Meta-analysis. Principles and Practice of Clinical Research. 2022;7(4):47–57. https://doi.org/10.21801/ppcrj.2021.74.6 Not only can meta-analyses provide an estimate of the un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Psychiatry
''Molecular Psychiatry'' is a peer-reviewed scientific journal published by Nature Publishing Group. It covers research in biological psychiatry. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', ''Molecular Psychiatry'' had an impact factor of 13.437 in 2021, ranking it 6th among 156 journals in the category "Psychiatry", 6th among 273 journals in the category "Neuroscience", and 11th among 298 journals in the category "Biochemistry & Molecular Biology". See also * List of psychiatry journals The following is a list of journals in the field of psychiatry. Psychiatry journals generally publish articles with either a general focus (meaning all aspects of psychiatry are included) or with a more specific focus. This list includes notable p ... * '' Translational Psychiatry'', its sister journal References External links * {{Official website, http://www.nature.com/mp/index.html Neuroscience journals Psychia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Personality Trait
In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality. Trait theorists are primarily interested in the measurement of ''traits'', which can be defined as habitual patterns of behaviour, thought, and emotion. According to this perspective, traits are aspects of personality that are relatively stable over time, differ across individuals (e.g. some people are outgoing whereas others are not), are relatively consistent over situations, and influence behaviour. Traits are in contrast to states, which are more transitory dispositions. In some theories and systems, traits are something a person either has or does not have, but in many others traits are dimensions such as extraversion vs. introversion, with each person rating somewhere along this spectrum. There are two approaches to define traits: as internal causal properties or as purely descriptive summaries. The internal causal definition states that traits influence our behav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single Nucleotide Polymorphism
In genetics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold. For example, at a specific base position in the human genome, the G nucleotide may appear in most individuals, but in a minority of individuals, the position is occupied by an A. This means that there is a SNP at this specific position, and the two possible nucleotide variations – G or A – are said to be the alleles for this specific position. SNPs pinpoint differences in our susceptibility to a wide range of diseases, for example age-related macular degeneration (a common SNP in the CFH gene is associated with increased risk of the disease) or nonalcoholic fatty liver disease (a SNP in the PNPLA3 gene is associated with incr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Novelty Seeking
In Cloninger's model of psychobiology, novelty seeking (NS) is an inherited, unlearned, temperamental bias toward novel signals from the environment. It can be measured along a spectrum from low to high (as with 3 other temperamental domains) and when toward the upper end of the spectrum, it is associated with higher exploratory activity, need for higher levels of baseline stimulation, impulsive decision making, extravagance in approach to reward cues, quick temperedness, low tolerance for frustration, impulsivity, and proneness to addiction. It is measured in the Tridimensional Personality Questionnaire as well as the later version Temperament and Character Inventory and is considered one of the ''temperament'' dimensions of personality. Like the other temperament dimensions, it has been found to be highly heritable. High NS has been suggested to be related to low dopaminergic activity. In the revised version of the Temperament and Character Inventory (TCI-R) novelty seeking c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
