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Bwamba Fever
''Bwamba orthobunyavirus'' (BWAV) belongs to the genus ''Orthobunyavirus'' and the order ''Bunyavirales'' RNA viruses. BWAV is present in large parts of Africa, endemic in Mozambique, Tanzania and Uganda. It is transmitted to humans through mosquito bites and results in a brief benign generalised infection with headache, skin rash, diarrhea and joint pain and lasts 4–5 days. The animal reservoir of the virus includes birds, monkeys and donkeys. Virus structure ''Bwamba orthobunyavirus'' has a negative sense single stranded RNA (ssRNA) genome, and so is classified as a class V virus under the Baltimore classification system. The genome is segmented into three pieces, Large (L), Medium (M) and Small (S), which have a combined length of approximately 12,000nt. The S RNA encodes a nucleocapsid and non structural proteins, the M RNA encodes envelope glycoproteins and a non structural membrane polypeptide and the L RNA encodes an RNA dependent RNA polymerase. The segmented RNAs are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bundibugyo Virus
The species ''Bundibugyo ebolavirus'' ( ) is the taxonomic home of one virus, Bundibugyo virus (BDBV), that forms filamentous virions and is closely related to the infamous Ebola virus (EBOV). The virus causes severe disease in humans in the form of viral hemorrhagic fever and is a Select agent, World Health Organization Risk Group 4 Pathogen (requiring Biosafety Level 4-equivalent containment), National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogen, Centers for Disease Control and Prevention Category A Bioterrorism Agent, and is listed as a Biological Agent for Export Control by the Australia Group. Use of term The species ''Bundibugyo ebolavirus'' is a virological taxon (i.e. a man-made concept) that was suggested in 2008 to be included in the genus ''Ebolavirus'', family ''Filoviridae'', order ''Mononegavirales''. The species has a single virus member, Bundibugyo virus (BDBV). The members of the species are called Bu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uganda Virus Research Institute
The Uganda Virus Research Institute (UVRI) is a medical research institute owned by the Uganda government that carries out research on communicable diseases in man and animals, with emphasis on viral transmitted infections. UVRI is a component of Uganda National Health Research Organization (UNHRO), an umbrella organization for health research within Uganda. Location UVRI is located at 51-59 Nakiwogo Road, in Entebbe, Uganda, approximately , south of Kampala, the capital and largest city in Uganda. The coordinates of the institute are: 0°04'33.0"N, 32°27'26.0"E (Latitude:0.075833; Longitude:32.457222). Overview The organisation was established in 1936 as the Yellow Fever Research Institute by the Rockefeller Foundation. In 1947, scientists researching yellow fever placed a rhesus macaque in a cage in the Zika Forest. The monkey developed a fever, and researchers isolated from its serum a transmissible agent that was first described as Zika virus in 1952. Other noteworthy arb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exanthem
An exanthem is a widespread rash occurring on the outside of the body and usually occurring in children. An exanthem can be caused by toxins, drugs, or microorganisms, or can result from autoimmune disease. The term exanthem is from the Greek el, ἐξάνθημα, translit=exánthēma, lit=a breaking out, label=none. It can be contrasted with enanthems which occur inside the body, such as on mucous membranes. Infectious exanthem In 1905, the Russian-French physician Léon Cheinisse (1871–1924), proposed a numbered classification of the six most common childhood exanthems. Of these six "classical" infectious childhood exanthems, four are viral. Numbers were provided in 1905. The four viral exanthema have much in common, and are often studied together as a class. They are: Scarlet fever, or "second disease", is associated with the bacterium ''Streptococcus pyogenes''. Fourth disease, also known as "Dukes' disease" is a condition whose existence is not widely accepted t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anopheles Funestus
''Anopheles funestus'' is a species of mosquito in the Culicidae family. This species was first described in 1900 by Giles. The female is attracted to houses where it seeks out humans in order to feed on their blood, mostly during the night. This mosquito is a major vector of malaria in sub-Saharan Africa. Distribution and habitat ''Anopheles funestus'' is found in tropical sub-Saharan Africa, its range extending from Senegal to Ethiopia, Angola, South Africa and Madagascar. Breeding takes place in water, any permanent or semi-permanent body of fresh water with some emergent vegetation being suitable, including swamps, lake verges, ponds and rice paddies. The larvae inhabit both sunlit and shaded locations, the vegetation probably being effective in reducing predation. In the Sahel, increased aridity has moved the northern limit of its range southward by about . Although it is considered to be a single species, part of a species complex, it shows some anomalies of behaviour ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anopheles Gambiae
The ''Anopheles gambiae'' complex consists of at least seven morphologically indistinguishable species of mosquitoes in the genus ''Anopheles''. The complex was recognised in the 1960s and includes the most important vectors of malaria in sub-Saharan Africa, particularly of the most dangerous malaria parasite, ''Plasmodium falciparum''. It is one of the most efficient malaria vectors known. The ''An. gambiae'' mosquito additionally transmits ''Wuchereria bancrofti'' which causes lymphatic filariasis, a symptom of which is elephantiasis. Discovery and elements The ''Anopheles gambiae'' complex or ''Anopheles gambiae'' sensu lato was recognized as a species complex only in the 1960s. The ''A. gambiae'' complex consists of: * '' Anopheles arabiensis'' * ''Anopheles bwambae'' * ''Anopheles melas'' * ''Anopheles merus'' * ''Anopheles quadriannulatus'' * ''Anopheles gambiae'' sensu stricto (s.s.) * ' * ''Anopheles amharicus'' The individual species of the complex are morphological ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vector (epidemiology)
In epidemiology, a disease vector is any living agent that carries and transmits an infectious pathogen to another living organism; agents regarded as vectors are organisms, such as parasites or microbes. The first major discovery of a disease vector came from Ronald Ross in 1897, who discovered the malaria pathogen when he dissected a mosquito. Arthropods Arthropods form a major group of pathogen vectors with mosquitoes, flies, sand flies, lice, fleas, ticks, and mites transmitting a huge number of pathogens. Many such vectors are haematophagous, which feed on blood at some or all stages of their lives. When the insects feed on blood, the pathogen enters the blood stream of the host. This can happen in different ways. The ''Anopheles'' mosquito, a vector for malaria, filariasis, and various arthropod-borne-viruses (arboviruses), inserts its delicate mouthpart under the skin and feeds on its host's blood. The parasites the mosquito carries are usually located in its salivary gla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. Symptoms usually begin ten to fifteen days after being bitten by an infected mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria. Malaria is caused by single-celled microorganisms of the ''Plasmodium'' group. It is spread exclusively through bites of infected ''Anopheles'' mosquitoes. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver where they mature and reproduce. Five species of ''Plasmodium'' can infect and be spread by h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endemic (epidemiology)
In epidemiology, an infection is said to be endemic in a specific population or populated place when that infection is constantly maintained at a baseline level without extra infections being brought into the group as a result of travel or similar means. An endemic disease always has a steady, predictable number of people getting sick, but that number can be high (''hyperendemic'') or low (''hypoendemic''), and the disease can be severe or mild. Also, a disease that is usually endemic can become epidemic. For example, chickenpox is endemic (steady state) in the United Kingdom, but malaria is not. Every year, there are a few cases of malaria reported in the UK, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus ''Anopheles''). Consequently, the number of people infected by malaria is too variable to be called endemic. However, the number of people who get chickenpox in the UK varies little from year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bundibugyo District
Bundibugyo District is a district in the Western Region of Uganda, bordering the Democratic Republic of the Congo (DRC). The town of Bundibugyo is where both the district headquarters and the Bwamba Kingdom seat ( Obudhingiya Bwa Bwamba) are located. Before July 2010, the districts of Ntoroko and Bundibugyo were one. These districts are the only two in Uganda that lie west of the Rwenzori mountains. Bundibugyo (With Ntoroko) was first named Semuliki district on separating it from the Greator Kabarole district alongside Rwenzori district (Kasese) in 1974. Location Via Karugutu Bundibugyo District is bordered by Ntoroko District to the northeast, Kabarole District to the east, Bunyangabu District to the southeast, Kasese District to the south and the D.R.C to the west and north. The district headquarters at Bundibugyo are located approximately , by road, west of Fort Portal city the capital of Rwenzori Sub-region. This is about , north of Kasese town but no motorable roads l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ambisense
In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids. Depending on the context, sense may have slightly different meanings. For example, negative-sense strand of DNA is equivalent to the template strand, whereas the positive-sense strand is the non-template strand whose nucleotide sequence is equivalent to the sequence of the mRNA transcript. DNA sense Because of the complementary nature of base-pairing between nucleic acid polymers, a double-stranded DNA molecule will be composed of two strands with sequences that are reverse complements of each other. To help molecular biologists specifically identify each strand individually, the two strands are usually differentiated as the "sense" strand and the "antisense" strand. An individual strand of DNA is referred to as positive-sense (also positive (+) or simply sense ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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