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Buyers Club
A buyers club or buying club is a club organized to pool members' collective buying power, enabling them to make purchases at lower prices than are generally available, or to purchase goods that might be difficult to obtain independently. Some key examples of buyers clubs include medical purchases of rare medications for treating HIV or hepatitis C sooner, at reduced cost for patients. Community bulk purchases In many parts of the United States, Canada, and Europe, families and individuals combine their purchasing power to buy items, typically bulk-type food, in a volume that generates a discounted price from the seller. The seller saves by having only one purchase order to manage and, possibly, less packaging and delivery to deal with. The buyers benefit from a lower per-unit cost and, incidentally, from an increased sense of community and sharing. Bulk-food sellers often provide tools so their customers can set up community buyers' clubs, for example:. The trend for buyers' clu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Club (organization)
A club is an association of people united by a common interest or goal. A service club, for example, exists for voluntary or charitable activities. There are clubs devoted to hobbies and sports, social activities clubs, political and religious clubs, and so forth. History Historically, clubs occurred in all ancient states of which exists detailed knowledge. Once people started living together in larger groups, there was need for people with a common interest to be able to associate despite having no ties of kinship. Organizations of the sort have existed for many years, as evidenced by Ancient Greek clubs and associations (''collegia'') in Ancient Rome. Origins of the word and concept It is uncertain whether the use of the word "club" originated in its meaning of a knot of people, or from the fact that the members "clubbed" together to pay the expenses of their gatherings. The oldest English clubs were merely informal periodic gatherings of friends for the purpose of dining ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zidovudine
Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. It may be used to prevent mother-to-child spread during birth or after a needlestick injury or other potential exposure. It is sold both by itself and together as lamivudine/zidovudine and abacavir/lamivudine/zidovudine. It can be used by mouth or by slow injection into a vein. Common side effects include headaches, fever, and nausea. Serious side effects include liver problems, muscle damage, and high blood lactate levels. It is commonly used in pregnancy and appears to be safe for the baby. ZDV is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. It works by inhibiting the enzyme reverse transcriptase that HIV uses to make DNA and therefore decreases replication of the virus. Zidovudine was first described in 1964. It was approved in the United States i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orlando Sentinel
The ''Orlando Sentinel'' is the primary newspaper of Orlando, Florida, and the Central Florida region. It was founded in 1876 and is currently owned by Tribune Publishing Company. The ''Orlando Sentinel'' is owned by parent company, '' Tribune Publishing''. This company was acquired by Alden Global Capital, which operates its media properties through Digital First Media, in May 2021. The newspaper's website utilizes geo-blocking, thus making it unaccessible from European countries. History The ''Sentinel''s predecessors date to 1876, when the ''Orange County Reporter'' was first published. The ''Reporter'' became a daily newspaper in 1905, and merged with the ''Orlando Evening Star'' in 1906. Another Orlando paper, the ''South Florida Sentinel'', started publishing as a morning daily in 1913. Then known as the ''Morning Sentinel'', it bought the ''Reporter-Star'' in 1931, when Martin Andersen came to Orlando to manage both papers. Andersen eventually bought both papers outrigh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Payment Card Number
A payment card number, primary account number (PAN), or simply a card number, is the card identifier found on payment cards, such as credit cards and debit cards, as well as stored-value cards, gift cards and other similar cards. In some situations the card number is referred to as a bank card number. The card number is primarily a card identifier and may not directly identify the bank account number/s to which the card is/are linked by the issuing entity. The card number prefix identifies the issuer of the card, and the digits that follow are used by the issuing entity to identify the cardholder as a customer and which is then associated by the issuing entity with the customer's designated bank accounts. In the case of stored-value type cards, the association with a particular customer is only made if the prepaid card is reloadable. Card numbers are allocated in accordance with ISO/IEC 7812. The card number is typically embossed on the front of a payment card, and is encoded on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tom Miller (politician)
Thomas John Miller (born August 11, 1944) is an American lawyer and politician serving as the 33rd and current Attorney General of Iowa. After the defeat of West Virginia Attorney General Darrell McGraw in 2012 when running for reelection, Miller became the longest serving State Attorney General in the United States, having been in office since 1995. A member of the Democratic Party, he previously served in the same position from 1979 to 1991 as the state's 31st Attorney General. Miller's combined tenure of over 38 years in office makes him the longest serving State Attorney General in United States history, having surpassed Frank J. Kelley's 37-year term of office as Michigan Attorney General; Kelley still holds the record for longest ''continuous'' tenure as an attorney general, having served from 1961 to 1999. Early life and education Miller was raised in Dubuque, Iowa to parents Elmer and Betty Miller. His father was a longtime county assessor. He graduated from Wahlert Ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Federal Trade Commission
The Federal Trade Commission (FTC) is an independent agency of the United States government whose principal mission is the enforcement of civil (non-criminal) antitrust law and the promotion of consumer protection. The FTC shares jurisdiction over federal civil antitrust enforcement with the Department of Justice Antitrust Division. The agency is headquartered in the Federal Trade Commission Building in Washington, DC. The FTC was established in 1914 with the passage of the Federal Trade Commission Act, signed in response to the 19th-century monopolistic trust crisis. Since its inception, the FTC has enforced the provisions of the Clayton Act, a key antitrust statute, as well as the provisions of the FTC Act, et seq. Over time, the FTC has been delegated with the enforcement of additional business regulation statutes and has promulgated a number of regulations (codified in Title 16 of the Code of Federal Regulations). The broad statutory authority granted to the FTC provide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ledipasvir
Ledipasvir is a drug for the treatment of hepatitis C that was developed by Gilead Sciences. After completing Phase III clinical trials, on February 10, 2014, Gilead filed for U.S. approval of a ledipasvir/sofosbuvir fixed-dose combination tablet for genotype 1 hepatitis C. The ledipasvir/sofosbuvir combination is a direct-acting antiviral agent that interferes with HCV replication and can be used to treat patients with genotypes 1a or 1b without PEG-interferon or ribavirin. Ledipasvir is an inhibitor of NS5A, a hepatitis C virus protein. Data presented at the 20th Conference on Retroviruses and Opportunistic Infections in March 2013 showed that a triple regimen of the nucleotide analog inhibitor sofosbuvir, ledipasvir, and ribavirin produced a 12-week post-treatment sustained virological response (SVR12) rate of 100% for both treatment-naive patients and prior non-responders with HCV genotype 1. The sofosbuvir/ledipasvir coformulation is being tested with and without ribavir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daclatasvir
Daclatasvir, sold under the brand name Daklinza, is an antiviral medication used in combination with other medications to treat hepatitis C (HCV). The other medications used in combination include sofosbuvir, ribavirin, and interferon, vary depending on the virus type and whether the person has cirrhosis. It is taken by mouth. Common side effects when used with sofusbivir and daclatasvir include headache, feeling tired, and nausea. With daclatasvir, sofosbuvir, and ribavirin the most common side effects are headache, feeling tired, nausea, and red blood cell breakdown. It should not be used with St. John's wort, rifampin, or carbamazepine. It works by inhibiting the HCV protein NS5A. Daclatasvir was approved for use in the European Union in 2014, and the United States and India in 2015. It is on the World Health Organization's List of Essential Medicines. The brand Daklinza is being withdrawn by Bristol Myers Squibb in countries where the drug is not typically prescribed, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sofosbuvir
Sofosbuvir, sold under the brand name Sovaldi among others, is a medication used to treat hepatitis C. It is taken Oral administration, by mouth. Common side effects include fatigue, headache, nausea, and trouble sleeping. Side effects are generally more common in interferon-containing regimens. Sofosbuvir may reactivate hepatitis B in those who have been previously infected. In combination with ledipasvir, daclatasvir or simeprevir, it is not recommended with amiodarone due to the risk of an bradycardia, abnormally slow heartbeat. Sofosbuvir is in the nucleotide analog family of medications and works by blocking the hepatitis C NS5B protein. Sofosbuvir was discovered in 2007 and approved for medical use in the United States in 2013. It is on the WHO Model List of Essential Medicines, World Health Organization's List of Essential Medicines. Medical uses Initial HCV treatment In 2016, the American Association for the Study of Liver Diseases and the Infectious Diseases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Sydney Morning Herald
''The Sydney Morning Herald'' (''SMH'') is a daily compact newspaper published in Sydney, New South Wales, Australia, and owned by Nine. Founded in 1831 as the ''Sydney Herald'', the ''Herald'' is the oldest continuously published newspaper in Australia and "the most widely-read masthead in the country." The newspaper is published in compact print form from Monday to Saturday as ''The Sydney Morning Herald'' and on Sunday as its sister newspaper, '' The Sun-Herald'' and digitally as an online site and app, seven days a week. It is considered a newspaper of record for Australia. The print edition of ''The Sydney Morning Herald'' is available for purchase from many retail outlets throughout the Sydney metropolitan area, most parts of regional New South Wales, the Australian Capital Territory and South East Queensland. Overview ''The Sydney Morning Herald'' publishes a variety of supplements, including the magazines ''Good Weekend'' (included in the Saturday edition of ''Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dallas Buyers Club
''Dallas Buyers Club'' is a 2013 American biographical drama film written by Craig Borten and Melisa Wallack, and directed by Jean-Marc Vallée. The film tells the story of Ron Woodroof (Matthew McConaughey), an AIDS patient diagnosed in the mid-1980s when HIV/AIDS treatments were under-researched, while the disease was not understood and was highly stigmatized. As part of the experimental AIDS treatment movement, he smuggled unapproved pharmaceutical drugs into Texas for treating his symptoms, and distributed them to fellow people with AIDS by establishing the "Dallas Buyers Club" while facing opposition from the Food and Drug Administration (FDA). Two fictional supporting characters, Dr. Eve Saks (Jennifer Garner), and Rayon ( Jared Leto), were composite roles created from interviews with transgender AIDS patients, activists, and doctors. Presidential biographer and PEN-USA winner Bill Minutaglio wrote the first magazine profile of the Dallas Buyers Club in 1992. The article, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dinitrochlorobenzene
2,4-Dinitrochlorobenzene (DNCB) is an organic compound with the chemical formula (O2N)2C6H3Cl. It is a yellow solid that is soluble in organic solvents. It is an important intermediate for the industrial production of other compounds. DNCB is produced commercially by the nitration of ''p''-nitrochlorobenzene with a mixture of nitric and sulfuric acids. Other methods afford the compound less efficiently include the chlorination of dinitrobenzene, nitration of o-nitrochlorobenzene and the dinitration of chlorobenzene. Uses By virtue of the two nitro groups, the chloride is susceptible to nucleophilic substitution. In this way, the compound is a precursor to many other compounds. Laboratory use DNCB is used as a substrate in GST enzyme activity assays. The molecule is conjugated to a single molecule of reduced glutathione which then absorbs at 340 nm. Affinity of CDNB for each class of GST varies and so it is not a good measure of activity for some forms (e.g. GSTT and G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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