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Bis(trifluoromethanesulfonyl)aniline
Bis(trifluoromethanesulfonyl)aniline is the organic compound with the formula C6H5N(SO2CF3)2.{{cite journal, title=N-Phenyltrifluoromethanesulfonimide , last1=Zeller, first1=Wayne E., last2=Schwörer, first2=Ralf, journal=E-EROS Encyclopedia of Reagents for Organic Synthesis, year=2009, doi=10.1002/047084289X.rp142.pub2, isbn=978-0471936237 It is a white solid. The compound is used to install the triflyl group (SO2CF3). Its behavior is akin to that of triflic anhydride, but milder. See also * Comins' reagent The Comins' reagent is a triflyl-donating reagent that is used to synthesize vinyl triflates from the corresponding ketone enolates or dienolates. It was first reported in 1992 by Daniel Comins. The vinyl triflates prepared are useful as sub ..., a related triflating reagent. References Triflates Amides Reagents for organic chemistry Phenyl compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triflyl
In organic chemistry, the triflyl group (systematic name: trifluoromethanesulfonyl group) is a functional group with the formula and structure . The triflyl group is often represented by –Tf. The related triflate group (trifluoromethanesulfonate) has the formula , and is represented by –OTf. See also * Triflyl azide, TfN3 * Trioctylmethylammonium bis(trifluoromethylsulfonyl)imide, * Comins' reagent * Bis(trifluoromethanesulfonyl)aniline * Triflic anhydride Trifluoromethanesulfonic anhydride, also known as triflic anhydride, is the chemical compound with the formula (CF3SO2)2O. It is the acid anhydride derived from triflic acid. This compound is a strong electrophile, useful for introducing the trif ... (CF3SO2)2O is a very strong triflating agent. References {{organic-chemistry-stub Triflyl compounds Functional groups ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Comins' Reagent
The Comins' reagent is a triflyl-donating reagent that is used to synthesize vinyl triflates from the corresponding ketone enolates or dienolates. It was first reported in 1992 by Daniel Comins. The vinyl triflates prepared are useful as substrates in the Suzuki reaction. See also * Bis(trifluoromethanesulfonyl)aniline Bis(trifluoromethanesulfonyl)aniline is the organic compound with the formula C6H5N(SO2CF3)2.{{cite journal, title=N-Phenyltrifluoromethanesulfonimide , last1=Zeller, first1=Wayne E., last2=Schwörer, first2=Ralf, journal=E-EROS Encyclopedia of Re ... References Reagents for organic chemistry Chloropyridines Sulfonamides Trifluoromethyl compounds Substances discovered in the 1990s {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triflates
In organic chemistry, triflate (systematic name: trifluoromethanesulfonate), is a functional group with the formula and structure . The triflate group is often represented by , as opposed to −Tf, which is the triflyl group, . For example, ''n''-butyl triflate can be written as . The corresponding triflate anion, , is an extremely stable polyatomic ion; this comes from the fact that triflic acid () is a superacid; i.e. it is more acidic than pure sulfuric acid, already one of the strongest acids known. Applications A triflate group is an excellent leaving group used in certain organic reactions such as nucleophilic substitution, Suzuki couplings and Heck reactions. Since alkyl triflates are extremely reactive in SN2 reactions, they must be stored in conditions free of nucleophiles (such as water). The anion owes its stability to resonance stabilization which causes the negative charge to be spread symmetrically over the three oxygen atoms. An additional stabilization is ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The study of the properties, reactions, and syntheses of organic compounds comprise the discipline known as organic chemistry. For historical reasons, a few classes of carbon-containing compounds (e.g., carbonate salts and cyanide salts), along with a few other exceptions (e.g., carbon dioxide, hydrogen cyanide), are not classified as organic compounds and are considered inorganic. Other than those just named, little consensus exists among chemists on precisely which carbon-containing compounds are excluded, making any rigorous definition of an organic compound elusive. Although organic compounds make up only a small percentage of Earth's crust, they are of central importance because all known life is based on organic compounds. Living t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triflic Anhydride
Trifluoromethanesulfonic anhydride, also known as triflic anhydride, is the chemical compound with the formula (CF3SO2)2O. It is the acid anhydride derived from triflic acid. This compound is a strong electrophile, useful for introducing the triflyl group, CF3SO2. Abbreviated Tf2O, triflic anhydride is the acid anhydride of the strong acid triflic acid, CF3SO2OH. Preparation and uses Triflic anhydride is prepared by dehydration of triflic acid using P4O10. Triflic anhydride is useful for converting ketones into enol triflates. In a representative application, is used to convert an imine into a NTf group. It will convert phenols into a triflic ester, which enables cleavage of the C-O bond. Assay The typical impurity in triflic anhydride is triflic acid, which is also a colorless liquid. Samples of triflic anhydride can be assayed by 19F NMR spectroscopy: −72.6 ppm vs. −77.3 for TfOH (std CFCl3). Safety It is an aggressive electrophile and readily hydrolyzes to the strong ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amides
In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula , where R, R', and R″ represent organic groups or hydrogen atoms. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. It can be viewed as a derivative of a carboxylic acid () with the hydroxyl group () replaced by an amine group (); or, equivalently, an acyl (alkanoyl) group () joined to an amine group. Common examples of amides are acetamide (), benzamide (), and dimethylformamide (). Amides are qualified as primary, secondary, and tertiary according to whether the amine subgroup has the form , , or , where R and R' are groups other than hydrogen. The core of amides is called the amide group (specifically, carboxamide group). Amides are pervasive in nature and technology. Proteins and important plastics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reagents For Organic Chemistry
In chemistry, a reagent ( ) or analytical reagent is a substance or compound added to a system to cause a chemical reaction, or test if one occurs. The terms ''reactant'' and ''reagent'' are often used interchangeably, but reactant specifies a substance ''consumed'' in the course of a chemical reaction. ''Solvents'', though involved in the reaction mechanism, are usually not called reactants. Similarly, ''catalysts'' are not consumed by the reaction, so they are not reactants. In biochemistry, especially in connection with enzyme-catalyzed reactions, the reactants are commonly called substrates. Definitions Organic chemistry In organic chemistry, the term "reagent" denotes a chemical ingredient (a compound or mixture, typically of inorganic or small organic molecules) introduced to cause the desired transformation of an organic substance. Examples include the Collins reagent, Fenton's reagent, and Grignard reagents. Analytical chemistry In analytical chemistry, a reagent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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