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BioSentinel
BioSentinel is a lowcost CubeSat spacecraft on a astrobiology mission that will use budding yeast to detect, measure, and compare the impact of deep space radiation on DNA repair over long time beyond low Earth orbit. Selected in 2013 for a 2022 launch, the spacecraft will operate in the deep space radiation environment throughout its 18-month mission. This will help scientists understand the health threat from cosmic rays and deep space environment on living organisms and reduce the risk associated with long-term human exploration, as NASA plans to send humans farther into space than ever before. The spacecraft has been launched on 16 November 2022 as part of the Artemis 1 mission. The mission is being developed by NASA Ames Research Center. Background BioSentinel is one of ten low-cost CubeSat missions that flew as secondary payloads aboard Artemis 1, the first test flight of NASA's Space Launch System. The spacecraft was deployed in cis-lunar space as NASA's first mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saccharomyces Cerevisiae
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been originally isolated from the skin of grapes. It is one of the most intensively studied eukaryotic model organisms in molecular biology, molecular and cell biology, much like ''Escherichia coli'' as the model bacteria, bacterium. It is the microorganism behind the most common type of fermentation (biochemistry), fermentation. ''S. cerevisiae'' cells are round to ovoid, 5–10 micrometre, μm in diameter. It reproduces by budding. Many proteins important in human biology were first discovered by studying their Homology (biology), homologs in yeast; these proteins include cell cycle proteins, signaling proteins, and protein-processing enzymes. ''S. cerevisiae'' is currently the only yeast cell known to have Berkeley body, Berkeley bo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Artemis 1
Artemis 1, officially Artemis I and formerly Exploration Mission-1 (EM-1), was an uncrewed Moon-orbiting mission. As the first major spaceflight of NASA's Artemis program, Artemis 1 marked the return of the agency to lunar exploration originally begun as the Apollo program decades earlier. It was the first integrated flight test of the Orion spacecraft and Space Launch System (SLS) rocket. Its main objective was to test the Orion spacecraft, especially its heat shield, in preparation for subsequent Artemis missions. These missions seek to reestablish a human presence on the Moon and demonstrate technologies and business approaches needed for future scientific studies, including exploration of Mars. The Orion spacecraft for Artemis 1 was stacked on October 20, 2021, marking the first time a super-heavy-lift vehicle has been stacked inside NASA's Vehicle Assembly Building (VAB) since the final Saturn V in 1973. On August 17, 2022, the fully stacked vehicle was rolled out fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Astrobiology
Astrobiology, and the related field of exobiology, is an interdisciplinary scientific field that studies the origins, early evolution, distribution, and future of life in the universe. Astrobiology is the multidisciplinary field that investigates the deterministic conditions and contingent events with which life arises, distributes, and evolves in the universe. Astrobiology makes use of molecular biology, biophysics, biochemistry, chemistry, astronomy, physical cosmology, exoplanetology, geology, paleontology, and ichnology to investigate the possibility of life on other worlds and help recognize biospheres that might be different from that on Earth. The origin and early evolution of life is an inseparable part of the discipline of astrobiology. Astrobiology concerns itself with interpretation of existing scientific data, and although speculation is entertained to give context, astrobiology concerns itself primarily with hypotheses that fit firmly into existing scientific ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Health Threat From Cosmic Rays
Health threats from cosmic rays are the dangers posed by cosmic rays to astronauts on interplanetary missions or any missions that venture through the Van-Allen Belts or outside the Earth's magnetosphere. They are one of the greatest barriers standing in the way of plans for interplanetary travel by crewed spacecraft, but space radiation health risks also occur for missions in low Earth orbit such as the International Space Station (ISS). In October 2015, the NASA Office of Inspector General issued a health hazards report related to space exploration, including a human mission to Mars. The deep-space radiation environment The radiation environment of deep space is different from that on the Earth's surface or in low Earth orbit, due to the much larger flux of high-energy galactic cosmic rays (GCRs), along with radiation from solar proton events (SPEs) and the radiation belts. Galactic cosmic rays (GCRs) consist of high energy protons (85%), alpha particles (14%) and oth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dosimeter
A radiation dosimeter is a device that measures dose uptake of external ionizing radiation. It is worn by the person being monitored when used as a personal dosimeter, and is a record of the radiation dose received. Modern electronic personal dosimeters can give a continuous readout of cumulative dose and current dose rate, and can warn the wearer with an audible alarm when a specified dose rate or a cumulative dose is exceeded. Other dosimeters, such as thermoluminescent or film types, require processing after use to reveal the cumulative dose received, and cannot give a current indication of dose while being worn. Personal dosimeters The personal ionising radiation dosimeter is of fundamental importance in the disciplines of radiation dosimetry and radiation health physics and is primarily used to estimate the radiation dose deposited in an individual wearing the device. Ionising radiation damage to the human body is cumulative, and is related to the total dose received, for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Absorbed Dose
Absorbed dose is a dose quantity which is the measure of the energy deposited in matter by ionizing radiation per unit mass. Absorbed dose is used in the calculation of dose uptake in living tissue in both radiation protection (reduction of harmful effects), and radiology (potential beneficial effects for example in cancer treatment). It is also used to directly compare the effect of radiation on inanimate matter such as in radiation hardening. The SI unit of measure is the gray (Gy), which is defined as one Joule of energy absorbed per kilogram of matter. The older, non-SI CGS unit rad, is sometimes also used, predominantly in the USA. Deterministic effects Conventionally, in radiation protection, unmodified absorbed dose is only used for indicating the immediate health effects due to high levels of acute dose. These are tissue effects, such as in acute radiation syndrome, which are also known as deterministic effects. These are effects which are certain to happen in a short ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rad (unit)
The rad is a unit of absorbed radiation dose, defined as 1 rad = 0.01 Gy = 0.01 J/kg. It was originally defined in CGS units in 1953 as the dose causing 100 ergs of energy to be absorbed by one gram of matter. The material absorbing the radiation can be human tissue or silicon microchips or any other medium (for example, air, water, lead shielding, etc.). It has been replaced by the gray (Gy) in SI derived units, but is still used in the United States, although this is "strongly discouraged" in Chapter 5.2 of the ''Guide to the SI'', which was written and published by the U.S. National Institute of Standards and Technology. However, the numerically equivalent SI unit, the centigray, is widely used to report absorbed doses within radiotherapy. The roentgen, used to quantify the radiation exposure, may be related to the corresponding absorbed dose by use of the F-factor. Health effects A dose of under 100 rad will typically produce no immediate symptoms other than blood ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solar Particle Event
In solar physics, a solar particle event (SPE), also known as a solar energetic particle (SEP) event or solar radiation storm, is a solar phenomenon which occurs when particles emitted by the Sun, mostly protons, become accelerated either in the Sun's atmosphere during a solar flare or in interplanetary space by a coronal mass ejection shock. Other nuclei such as helium and HZE ions may also be accelerated during the event. These particles can penetrate the Earth's magnetic field and cause partial ionization of the ionosphere. Energetic protons are a significant radiation hazard to spacecraft and astronauts. Description SPEs occur when charged particles in the Sun's atmosphere are accelerated to extremely high velocities. These charged particles, referred to as solar energetic particles, can escape into interplanetary space where they follow the interplanetary magnetic field. When solar energetic particles interact with the Earth's magnetosphere, they are guided by the Earth's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Organism
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural recombination". A wide variety of organisms have been genetically modified (GM), from animals to plants and microorganisms. Genes have been transferred within the same species, across species (creating transgenic organisms), and even across kingdoms. New genes can be introduced, or endogenous genes can be enhanced, altered, or knocked out. Creating a genetically modified organism is a multi-step process. Genetic engineers must isolate the gene they wish to insert into the host organism and combine it with other genetic elements, including a promoter and terminator region and often a selectable marker. A number of techniques are a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Double Strand Breaks
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages (interstrand crosslinks or ICLs). This can eventually lead to maligna ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Damage
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages (interstrand crosslinks or ICLs). This can eventually lead to maligna ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Space Radiation
Health threats from cosmic rays are the dangers posed by cosmic rays to astronauts on interplanetary missions or any missions that venture through the Van-Allen Belts or outside the Earth's magnetosphere. They are one of the greatest barriers standing in the way of plans for interplanetary travel by crewed spacecraft, but space radiation health risks also occur for missions in low Earth orbit such as the International Space Station (ISS). In October 2015, the NASA Office of Inspector General issued a health hazards report related to space exploration, including a human mission to Mars. The deep-space radiation environment The radiation environment of deep space is different from that on the Earth's surface or in low Earth orbit, due to the much larger flux of high-energy galactic cosmic rays (GCRs), along with radiation from solar proton events (SPEs) and the radiation belts. Galactic cosmic rays (GCRs) consist of high energy protons (85%), alpha particles (14%) and ot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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