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Beverly M. Emerson
Beverly M. Emerson (born January 18, 1952) is an Emeritus Professor of Biological Sciences at the Salk Institute for Biological Studies who uncovered details about how cancer becomes drug resistant. She is currently at the Oregon Health & Science University’s Knight Cancer Institute. She is a Fellow of the American Association for the Advancement of Science. Early life and education Emerson was born in Eugene, Oregon. Her parents divorced when she was young and her mother became a traveller. Her father was an amateur boxer and he mother was a gambler. Emerson attended the La Châtelainie School for Girls in Neuchâtel for a year. She studied biology at the University of California, San Diego. To support her studies, she worked as a carhop at Shoney's and a waitress at a steakhouse. During her undergraduate studies she spent a year at the University of St Andrews (1972), where she worked with Donald Helinski and Peter Geiduschek. She joined Washington University in St. Louis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eugene, Oregon
Eugene ( ) is a city in the U.S. state of Oregon. It is located at the southern end of the Willamette Valley, near the confluence of the McKenzie and Willamette rivers, about east of the Oregon Coast. As of the 2020 United States Census, Eugene had a population of 176,654 and covers city area of 44.21 sq mi (114.50 sq km). Eugene is the seat of Lane County and the state's second largest city after Portland. The Eugene-Springfield metropolitan statistical area is the 146th largest in the United States and the third largest in the state, behind those of Portland and Salem. In 2022, Eugene's population was estimated to have reached 179,887. Eugene is home to the University of Oregon, Bushnell University, and Lane Community College. The city is noted for its natural environment, recreational opportunities (especially bicycling, running/jogging, rafting, and kayaking), and focus on the arts, along with its history of civil unrest, protests, and green activism. Eugene's offi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Katherine Jones (academic)
Katherine A. Jones is a professor of regulatory biology and the Edwin K. Hunter Chair at the Salk Institute for Biological Studies. She uses proteomics to study transcription elongation and molecular biology to understand protein coordination. Jones identified elongation factors, a class of proteins which are important in viral gene expression. Early life and education Jones earned her PhD in biochemistry at the University of California, Riverside. She was made a Pew Scholar in 1987. Her Pew Foundation fellowship allowed her to study the transcription mechanisms that are responsible for rapid induction in mammalian genes. Jones showed how the RNA polymerase II transcription factor Sp1 binds to DNA and activates RNA. Research and career Jones is a professor of regulatory biology and Edwin K. Hunter Chair at the Salk Institute for Biological Studies. Jones holds an adjunct position at University of California, San Diego. She has worked extensively on understanding the Huma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oregon Health & Science University Faculty
Oregon () is a state in the Pacific Northwest region of the Western United States. The Columbia River delineates much of Oregon's northern boundary with Washington, while the Snake River delineates much of its eastern boundary with Idaho. The 42° north parallel delineates the southern boundary with California and Nevada. Oregon has been home to many indigenous nations for thousands of years. The first European traders, explorers, and settlers began exploring what is now Oregon's Pacific coast in the early-mid 16th century. As early as 1564, the Spanish began sending vessels northeast from the Philippines, riding the Kuroshio Current in a sweeping circular route across the northern part of the Pacific. In 1592, Juan de Fuca undertook detailed mapping and studies of ocean currents in the Pacific Northwest, including the Oregon coast as well as the strait now bearing his name. Spanish ships – 250 in as many years – would typically not land before reaching Cape Mendocin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, San Diego Faculty
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, San Diego Alumni
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inder Verma
Inder Mohan Verma (born 28 November 1947) is an Indian American molecular biologist, the former Cancer Society Professor of Molecular Biology in the Laboratory of Genetics at the Salk Institute for Biological Studies and the University of California, San Diego. He is recognized for seminal discoveries in the fields of cancer, immunology, and gene therapy. Verma was the editor-in-chief of the journal ''Proceedings of the National Academy of Sciences of the United States of America'' (''PNAS'') from 2011 to 2018, but stepped down after being named in a gender discrimination lawsuit against the Salk Institute. In April 2018 the Salk institute placed him on leave for "unspecified allegations"; Verma himself stated that the leave was connected to the same lawsuit, but it came shortly before publication of an exposé alleging decades-long sexual harassment and assault of multiple women by Verma. In June 2018 he resigned his position at the Salk Institute, before the board of trustees ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California Institute For Regenerative Medicine
The California Institute for Regenerative Medicine (CIRM) was created in 2004 after 59% of California voters approved California Proposition 71: the Research and Cures Initiative, which allocated $3 billion to fund stem cell research in California. Institutes dedicated to stem cell research and training exist at Sanford Consortium, University of California, Santa Cruz, Stanford University, University of California Davis, University of California Irvine, University of California San Francisco, University of California Los Angeles and University of Southern California. Five “Alpha Stem Cell Clinics have also been established to lead clinical trials for stem cell therapies at City of Hope, University of California San Diego, University of California San Francisco, University of California Davis and a joint clinic at University of California Los Angeles and University of California Irvine. History CIRM was established via California Proposition 71 (2004). However, its implementation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zinc Finger
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. It was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (''Xenopus laevis'') transcription factor IIIA. However, it has been found to encompass a wide variety of differing protein structures in eukaryotic cells. ''Xenopus laevis'' TFIIIA was originally demonstrated to contain zinc and require the metal for function in 1983, the first such reported zinc requirement for a gene regulatory protein followed soon thereafter by the Krüppel factor in ''Drosophila''. It often appears as a metal-binding domain in multi-domain proteins. Proteins that contain zinc fingers (zinc finger proteins) are classified into several different structural families. Unlike many other clearly defined supersecondary structures such as Greek keys or β hairpins, there are a number of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EKLF
Krueppel-like factor 1 is a protein that in humans is encoded by the KLF1 gene. The gene for KLF1 is on the human chromosome 19 and on mouse chromosome 8. Krueppel-like factor 1 is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells. Structure The molecule has two domains; the transactivation domain and the chromatin-remodeling domain. The carboxyl (C) terminal is composed of three C2H2 zinc fingers that binds to DNA, and the amino (N) terminus is proline rich and acidic. Function Studies in mice first demonstrated the critical function of KLF1 in hematopoietic development. KLF1 deficient (knockout) mouse embryos exhibit a lethal anemic phenotype, fail to promote the transcription of adult β-globin, and die by embryonic day 15. Over-expression of KLF1 results in a reduction of the number of circulating platelets and hastens the onset of the β-globin gene. KLF1 coordinates the regulation of six cellular pathways that are all es ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beta Globin
Hemoglobin subunit beta (beta globin, β-globin, haemoglobin beta, hemoglobin beta) is a globin protein, coded for by the ''HBB'' gene, which along with alpha globin ( HBA), makes up the most common form of haemoglobin in adult humans, hemoglobin A (HbA). It is 147 amino acids long and has a molecular weight of 15,867 Da. Normal adult human HbA is a heterotetramer consisting of two alpha chains and two beta chains. HBB is encoded by the ''HBB'' gene on human chromosome 11. Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria. At least 50 disease-causing mutations in this gene have been discovered. Gene locus HBB protein is produced by the gene ''HBB'' which is located in the multigene locus of β-globin locus on chromosome 11, specifically on the short arm position 15.4. Expression of beta globin and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Tissue
The breast is one of two prominences located on the upper ventral region of a primate's torso. Both females and males develop breasts from the same embryological tissues. In females, it serves as the mammary gland, which produces and secretes milk to feed infants. Subcutaneous fat covers and envelops a network of ducts that converge on the nipple, and these tissues give the breast its size and shape. At the ends of the ducts are lobules, or clusters of alveoli, where milk is produced and stored in response to hormonal signals. During pregnancy, the breast responds to a complex interaction of hormones, including estrogens, progesterone, and prolactin, that mediate the completion of its development, namely lobuloalveolar maturation, in preparation of lactation and breastfeeding. Humans are the only animals with permanent breasts. At puberty, estrogens, in conjunction with growth hormone, cause permanent breast growth in female humans. This happens only to a much less ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Precancerous Condition
A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk of developing into cancer. Clinically, precancerous conditions encompass a variety of abnormal tissues with an increased risk of developing into cancer. Some of the most common precancerous conditions include certain colon polyps, which can progress into colon cancer, monoclonal gammopathy of undetermined significance, which can progress into multiple myeloma or myelodysplastic syndrome. and cervical dysplasia, which can progress into cervical cancer. Bronchial premalignant lesions can progress to squamous cell carcinoma of the lung. Pathologically, precancerous tissue can range from benign neoplasias, which are tumors which don't invade neighboring normal tissues or spread to distant organs, to dysplasia, a collection of highly abnormal cells which, in some cases, has an increased risk of progressing to anaplasia and invasive cancer which is life-threat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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