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Benproperine
Benproperine ( INN) is a cough suppressant. It has been marketed in multiple countries in Central America and Europe, as the phosphate or pamoate salts in either tablet, dragée, or syrup form. Trade names include Blascorid in Italy and Sweden, Pectipront and Tussafug in Germany, and Pirexyl in Scandinavia. The recommended dosage for adults is 25 to 50 mg two to four times daily, and for children 25 mg once or twice daily. Adverse effects include dry mouth, dizziness, fatigue, and heartburn. Synthesis The base catalyzed ether formation between 2-Benzylphenol 8994-41-4(1) and 1,2-dichloropropane 1,2-Dichloropropane is an organic compound classified as a chlorocarbon. It is a colorless, flammable liquid with a sweet odor. it is obtained as a byproduct of the production of epichlorohydrin, which is produced on a large scale.Manfred Rossb ... (2) gives 1-benzyl-2-(2-chloropropoxy)benzene 5909-36-0(3). Displacement of the remaining halogen with piperidine completes the synthe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benproperine Synthesis
Benproperine (International Nonproprietary Name, INN) is a cough suppressant. It has been marketed in multiple countries in Central America and Europe, as the phosphate or pamoate salts in either tablet, dragée, or syrup form. Trade names include Blascorid in Italy and Sweden, Pectipront and Tussafug in Germany, and Pirexyl in Scandinavia. The recommended dosage for adults is 25 to 50 mg two to four times daily, and for children 25 mg once or twice daily. Adverse effects include dry mouth, dizziness, fatigue, and heartburn. Synthesis The base catalyzed ether formation between 2-Benzylphenol [28994-41-4] (1) and 1,2-dichloropropane (2) gives 1-benzyl-2-(2-chloropropoxy)benzene [85909-36-0] (3). Displacement of the remaining halogen with piperidine completes the synthesis of ''benproperine'' (4). References Antitussives 1-Piperidinyl compounds 2-Phenoxyethanamines Abandoned drugs {{respiratory-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
