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2A Self-cleaving Peptides
2A self-cleaving peptides, or 2A peptides, is a class of 18–22 aa-long peptides, which can induce ribosomal skipping during translation of a protein in a cell. These peptides share a core sequence motif of , and are found in a wide range of viral families. They help generating polyproteins by causing the ribosome to fail at making a peptide bond. The members of 2A peptides are named after the virus in which they have been first described. For example, F2A, the first described 2A peptide, is derived from foot-and-mouth disease virus. The name "2A" itself comes from the gene numbering scheme of this virus. Members Four members of 2A peptides family are frequently used in life science research. They are P2A, E2A, F2A, and T2A. F2A is derived from foot-and-mouth disease virus 18; E2A is derived from equine rhinitis A virus; P2A is derived from porcine teschovirus-1 2A; T2A is derived from thosea asigna virus 2A. The following table shows the sequences of four members of 2A pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alberta Highway 2A
Alberta Provincial Highway No. 2A is the designation of six alternate routes off Highway 2 in Alberta, Canada. In general, these are original sections of Highway 2, such as the southern portion of Macleod Trail in Calgary. They passed through communities before limited-access freeways were built to shorten driving distance, accommodate heavier volumes and to bypass city traffic. Portions of the alignment of Highway 2A follow the route of the former Calgary and Edmonton Trail. High River – Calgary Highway 2A currently begins in the Town of High River and follows 12 Avenue SE and Centre Street before passing by Aldersyde and intersecting Highway 7. The highway then travels westward to the Town of Okotoks, where it branches north and follows Southridge Drive and Northridge Drive through Okotoks before rejoining Highway 2 near De Winton. In 2003, it was extended north by sharing a common alignment with Highway 2 for until it splits to Deerfoot Trail (Highway 2) Macleod T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Route 2A
Route 2A is a east–west state highway in Massachusetts. It exists in several sections of Massachusetts, mainly as parts of former Route 2 that have been moved or upgraded. Route 2A runs from Greenfield in the west to Boston in the east. It formerly extended to Shelburne Falls in Buckland in the west, but as of 2007, the route terminates at Interstate 91 (I-91) in Greenfield. Route description Route 2A begins at the rotary intersection with Route 2 at I-91 in Greenfield. It passes through downtown Greenfield before reconnecting to its parent route just west of the Greenfield-Gill town line. After a silent concurrency, Route 2A leaves Route 2 once more, passing through Orange and Athol. In Athol it passes the former northern terminus of Route 21, which was truncated to Belchertown after the creation of the Quabbin Reservoir. From Phillipston through Westminster, Route 2A weaves around its parent route, crossing it a total o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-2A Adrenergic Receptor
The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it. Receptor α2 adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the α2A and α2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the α2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α2C subtype modulated neurotransmission at lower levels of nerve activity Gene This gene encodes α2A subtype and it contains no introns in either its coding or untranslated sequences. Role in central nervous system Although the pre-synaptic functions of α2A receptors are often ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor II A
Transcription factor TFIIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. TFIIA is one of several general (basal) transcription factors ( GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TFIID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TFIIB, TFIIE, TFIIF, and TFIIH. Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template. Functions TFIIA interacts with the TBP subunit of TFIID and aids in the binding of TBP to TATA-box containing promoter DNA. Interaction of TFIIA with TBP facilitates formation of and stabilizes the preinitiation complex. Interaction of TFIIA with TBP also results in the exclusion of negative (repressive) factors that might otherwise bind to TBP and interfere ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Second Amendment To The United States Constitution
The Second Amendment (Amendment II) to the United States Constitution protects the Right to keep and bear arms in the United States, right to keep and bear arms. It was ratified on December 15, 1791, along with nine other articles of the United States Bill of Rights, Bill of Rights. In ''District of Columbia v. Heller'' (2008), the Supreme Court of the United States, Supreme Court affirmed for the first time that the right belongs to individuals, for self-defense in the home, while also including, as ''dicta'', that the right is not unlimited and does not preclude the existence of certain long-standing prohibitions such as those forbidding "the possession of firearms by felons and the mentally ill" or restrictions on "the carrying of dangerous and unusual weapons". In ''McDonald v. City of Chicago'' (2010) the Supreme Court ruled that State governments of the United States, state and Local government in the United States, local governments are Incorporation of the Bill of Rig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keratin 2A
Keratin 2A also known as keratin 2E or keratin 2 is a protein that in humans is encoded by the ''KRT2A'' gene. Keratin 2A is a type II cytokeratin. It is found largely in the upper spinous layer of epidermal keratinocytes and mutations in the gene encoding this protein have been associated with ichthyosis bullosa of Siemens Ichthyosis bullosa of Siemens is a type of familial, autosomal dominant ichthyosis, a rare skin disorder.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . It is also known as bullous congenital .... References Further reading * * * * * * * * * * * * * * * * * * * External links * Keratins {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corse-du-Sud
Corse-du-Sud (; co, link=no, Corsica suttana , or ; en, Southern Corsica) is (as of 2019) an administrative department of France, consisting of the southern part of the island of Corsica. The corresponding departmental territorial collectivity merged with that of Haute-Corse on 1 January 2018, forming the single territorial collectivity of Corsica, with territorial elections coinciding with the dissolution of the separate council. However, even though its administrative powers were ceded to the new territorial collectivity, it continues to remain an administrative department in its own right. In 2019, it had a population of 158,507.Populations légales 2019: 2A Corse-du-Sud INSEE History [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deutsche Bahn
The (; abbreviated as DB or DB AG) is the national railway company of Germany. Headquartered in the Bahntower in Berlin, it is a joint-stock company ( AG). The Federal Republic of Germany is its single shareholder. describes itself as the second-largest transport company in the world, after the German postal and logistics company / DHL, and is the largest railway operator and infrastructure owner in Europe. Deutsche Bahn was the largest railway company in the world by revenue in 2015; in 2019, DB Passenger transport companies carried around 4.8 billion passengers, and DB logistics companies transported approximately 232 million tons of goods in rail freight transport. The group is divided into several companies, including ''DB Fernverkehr'' (long-distance passenger), '' DB Regio'' (local passenger services) and ''DB Cargo'' (rail freight). The Group subsidiary ''DB Netz'' also operates large parts of the German railway infrastructure, making it the largest rail network in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
A2 (other)
A2, A02, A002, A², A.II or A-2 may refer to: Biology and medicine * British NVC community A2 (Lemna minor community), a plant community * A2, the second anal vein in the Comstock-Needham system of insect wing segment naming Genes and proteins * A-box 2 of insulin gene * HLA-A2, a human MHC HLA-A serotype gene * Ectodysplasin A2 receptor, a protein that in humans is encoded by the EDA2R gene * Alpha-2 adrenergic receptor * Annexin A2, a protein * Apolipoprotein A2, a protein * Phospholipase A2 The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glyce ..., an enzyme * Prokaryotic phospholipase A2, an enzyme * Hemoglobin A2, a protein * Proanthocyanidin A2, an A type proanthocyanidin * Urea transporter A2, a protein * A2, a variant of blood groups alleles A in the ABO blood group system * A2, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stalag II-A
In Germany, stalag (; ) was a term used for prisoner-of-war camps. Stalag is a contraction of "Stammlager", itself short for ''Kriegsgefangenen-Mannschaftsstammlager'', a literal translation of which is "War-prisoner" (i.e. POW) "enlisted" "main camp". Therefore, technically "stalag" simply means "main camp". Legal definitions According to the Third Geneva Convention of 1929 and its predecessor, the Hague Convention of 1907, Section IV, Chapter 2, these camps were only for prisoners of war, not civilians. Stalags were operated in both World War I and World War II and were intended to be used for non-commissioned personnel (enlisted ranks in the US Army and other ranks in British Commonwealth forces). Officers were held in separate camps called ''Oflag''. During World War II, the ''Luftwaffe'' (German air force) operated ''Stalag Luft'' in which flying personnel, both officers and non-commissioned officers, were held. The ''Kriegsmarine'' (German navy) operated ''Marlag'' f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Telecom 2A
Telecom may refer to: * Telecommunications ** A telephone company (or ''telecommunications service provider'') ** The telecommunications industry * Telecom Animation Film, a Japanese studio See also * Telcom (other) * Telekom (other) * List of telephone operating companies ** BH Telecom, Bosnia and Herzegovina ** Bouygues Telecom, France ** BT Group, formerly British Telecom, United Kingdom ** China Telecom, China ** ER-Telecom, Russia ** Orange SA, formerly France Télécom ** Golan Telecom, Israel ** Hong Kong Telecom, China ** Nepal Telecom, Nepal ** Nortel, formerly Northern Telecom, Canada ** Rostelecom, Russia ** Telecom Argentina ** Telecom Éireann, Ireland ** Telecom Italia, Italy ** Telstra, formerly Telecom Australia ** Tunisie Telecom, Tunisia ** Spark New Zealand Spark New Zealand Limited is a New Zealand telecommunications company providing fixed-line telephone services, a mobile phone network, internet access services, and (through its Spa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
