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Vasopressin Receptor 1A
Vasopressin receptor 1A (V1AR), or arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major receptor types for vasopressin (Arginine vasopressin receptor 1B, AVPR1B and Arginine vasopressin receptor 2, AVPR2 being the others), and is present throughout the brain, as well as in the periphery in the liver, kidney, and vasculature. V1AR is also known as: * V1a vasopressin receptor * antidiuretic hormone receptor 1A * SCCL vasopressin subtype 1a receptor * V1-vascular vasopressin receptor AVPR1A * vascular/hepatic-type arginine vasopressin receptor Structure and function Human AVPR1A cDNA is 1472 bp long and encodes a 418 amino-acid long polypeptide which shares 72%, 36%, 37%, and 45% sequence identity with rat Avpr1a, human AVPR2, rat Avpr2, and human Oxytocin receptor, oxytocin receptor (OXTR), respectively. AVPR1A is a G protein-coupled receptor, G-protein coupled receptor (GPCR) with 7 transmembrane domains that couples to Gq alpha subunit, Gaq/11 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interferon Beta-1a
Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS). It is produced by mammalian cells, while interferon beta-1b is produced in modified '' E. coli''. Some research indicates that interferon injections may result in an 18–38% reduction in the rate of MS relapses. Interferon beta has not been shown to slow the advance of disability. Interferons are not a cure for MS (there is no known cure); the claim is that interferons may slow the progress of the disease if started early and continued for the duration of the disease. Medical uses Clinically isolated syndrome The earliest clinical presentation of relapsing-remitting multiple sclerosis is the clinically isolated syndrome (CIS), that is, a single attack of a single symptom. During a CIS, there is a subacute attack suggestive of demyelination which should be included in the spectrum of MS phenotypes. Treatment with interferons after an initial attac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1A (radio Program)
''1A'' is an American radio talk show produced by WAMU in Washington, D.C. and distributed nationally by NPR (National Public Radio). The show debuted on January 2, 2017, airing on more than 340 NPR member stations in 35 states, Washington, D.C., and the U.S. Virgin Islands. It is also heard on Sirius XM channel 122 several times each weekday. Jenn White is the host. Journalist Joshua Johnson served as the program's host from 2017 to 2019, before leaving to work for MSNBC. Todd Zwillich replaced him as interim host in January 2020. He was succeeded in this capacity by Sasha-Ann Simons in April. Celeste Headlee also served as an interim guest host. On May 7, 2020, WAMU announced that Jenn White would succeed Johnson as permanent host of ''1A'' beginning in July. Format ''1A'' is divided into two one-hour segments, which each focuses on a topic for the hour, with one or more guests who are authorities on that topic. Most often it is an issue in the news, but occasionally might ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Astra 1A
Astra 1A was the first satellite launched and operated by SES (Société Européenne des Satellites), launched in December 1988. During its early days, it was often referred to as the Astra Satellite, as SES only operated one satellite originally. The satellite provided television coverage to Western Europe from 1989 to 2004. Astra 1A was retired and became derelict in December 2004. Channels Among the channels carried in the early years after launch were the entire four channel Sky Television (later British Sky Broadcasting, after the merger with rival British Satellite Broadcasting on the Marcopolo satellite), the services consisted of Sky Channel, Sky News, Sky Movies and Eurosport, the Scandinavian TV3 and TV1000, the German Pro7, Sat.1, RTL plus, 3sat and Teleclub, the Dutch RTL 4 as well as FilmNet, Screensport, MTV Europe, The Children's Channel and Lifestyle. Astra 1A began television broadcasts on 5 February 1989. Until 1998 all of SES' satellites were co-locat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meltwater Pulse 1A
Meltwater pulse 1A (MWP1a) is the name used by Quaternary geologists, paleoclimatologists, and oceanographers for a period of rapid post-glacial sea level rise, between 13,500 and 14,700 calendar years ago, during which global sea level rose between and in about 400–500 years, giving mean rates of roughly /yr. Meltwater pulse 1A is also known as catastrophic rise event 1 (CRE1) in the Caribbean Sea.Blanchon, P., and J. Shaw (1995) ''Reef drowning during the last deglaciation: Evidence for catastrophic sea-level rise and ice-sheet collapse.'' Geology. 23(1):4-8. The rates of sea level rise associated with meltwater pulse 1A are the highest known rates of post-glacial, eustatic sea level rise. Meltwater pulse 1A is also the most widely recognized and least disputed of the named, postglacial meltwater pulses. Other named, postglacial meltwater pulses are known most commonly as ''meltwater pulse 1A0'' (''meltwater pulse 19ka''), ''meltwater pulse 1B'', ''meltwater pulse 1C'', ''mel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Melatonin Receptor 1A
Melatonin receptor type 1A is a protein that in humans is encoded by the ''MTNR1A'' gene. Function This gene encodes the MT1 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. Ligands # Melatonin – full agonist # Afobazole – agonist # Agomelatine – agonist See also * Melatonin receptor * Discovery and development of melatonin receptor agonists Melatonin receptor agonists are analogues of melatonin that bind to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Highways Numbered 1A
The following highways are numbered 1A: Canada * Alberta Highway 1A * British Columbia Highway 1A * Manitoba Highway 1A * Route 1A (Prince Edn mm...ward Island) Germany * Bundesstraße 1a, a German road India * New Zealand * New Zealand State Highway 1A United States * U.S. Route 1A * Delaware Route 1A * Massachusetts Route 1A * New Hampshire Route 1A * New York State Route 1A (former) * Rhode Island Route 1A * Secondary State Highway 1A (Washington) (former) Vietnam * National Route 1 (Vietnam) National Route 1 ( vi, Quốc lộ 1 (or abbrv. QL.1) or Đường 1, links=no), also known as National Route 1A, is the trans-Vietnam highway. The route begins at km 0 at Hữu Nghị Quan Border Gate near the China-Vietnam border, runs the len ..., also known as ''National Route 1'', a road connecting the northernmost and southernmost areas of the country See also mk {{Road index, 001A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1A Adrenergic Receptor
The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. There is no longer a subtype α1C receptor. At one time, there was a subtype known as α1C, but it was found to be identical to the previously discovered α1A receptor subtype. To avoid confusion, the naming convention was continued with the letter D. Receptor There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins. Different subtypes show different patterns of activation. The majority of alpha-1 receptors are directed toward the function of epinephrine, a hormone that has to do with the fight-or-flight response. Gene This gene encodes the alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-te ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shin Meiwa US-1A
The Shin Meiwa PS-1 and US-1A is a large STOL aircraft designed for anti-submarine warfare (ASW) and air-sea rescue (SAR) work respectively by Japanese aircraft manufacturer Shin Meiwa. The PS-1 anti-submarine warfare (ASW) variant is a flying boat which carried its own beaching gear on board, while the search-and-rescue (SAR) orientated US-1A is a true amphibian. Development of the PS-1 has its origins in flying boat research performed by the Shin Meiwa during the 1950s. The company, believing that their design was capable of regular use upon the open sea, petitioned the Japanese military to acquire the type as a maritime patrol aircraft (MPA). Following the demonstration of a converted Grumman HU-16 Albatross testbed aircraft, referred to as the UF-XS, the Japan Maritime Self-Defense Force (JMSDF) awarded Shin Meiwa a contract in 1966 to further develop its design via two further prototypes, which were designated PS-X. During 1969, the JMSDF placed the first order for an even ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sisu 1A
__NOTOC__ The Sisu 1A is a competition sailplane built in the United States in the late 1950s and early 1960s. Originally designed by Leonard Niemi as a homebuilt sailplane, its first flight in 1958 showed such promise that Niemi decided instead to manufacture it in series production. Niemi formed the Arlington Aircraft Company for this purpose. The Sisu 1A quickly proved itself as the most competitive American sailplane ever developed, winning the 1962, 1965, and 1967 U.S. National Soaring Championships. On July 31, 1964, a Sisu 1a piloted by Alvin H. Parker became the first sailplane ever to fly farther than 1000 km. Aircraft on display *The Arlington Sisu 1A that broke the 1000 km distance record was donated to the Smithsonian Institution and resides in the Udvar-Hazy Center (UHC) of the National Air and Space Museum. UHC is located in the Washington, DC suburb of Chantilly, VA near Dulles International Airport Washington Dulles International Airport , typi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mercury-Redstone 1A
Mercury- Redstone 1A (MR-1A) was launched on December 19, 1960 from LC-5 at Cape Canaveral, Florida. The mission objectives of this uncrewed suborbital flight were to qualify the spacecraft for space flight and qualify the system for an upcoming primate suborbital flight. The spacecraft tested its instrumentation, posigrade rockets, retrorockets and recovery system. The mission was completely successful. The Mercury capsule reached an altitude of and a range of . The launch vehicle reached a slightly higher velocity than expected - . The Mercury spacecraft was recovered from the Atlantic Ocean by recovery helicopters about 15 minutes after landing. Serial numbers: Mercury Spacecraft #2 was reflown on MR-1A, together with the escape tower from Capsule #8 and the antenna fairing from Capsule #10. Redstone MRLV-3 was used. The flight time was 15 minutes and 45 seconds. Mercury-Redstone suborbital flight events Current location Mercury spacecraft #2, used in both the Mercury-Reds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Little Joe 1A
Little Joe 1A (LJ-1A) was an unmanned rocket launched as part of NASA's Mercury program on November 4, 1959. This flight, a repeat of the Little Joe 1 (LJ-1) launch, was to test a launch abort under high aerodynamic load conditions. After lift-off, the pressure sensing system was to indicate when the correct abort dynamic pressure was reached. This should have happened about thirty seconds after launch. A signal was sent to the explosive bolts to separate the spacecraft from the launch vehicle A launch vehicle or carrier rocket is a rocket designed to carry a payload (spacecraft or satellites) from the Earth's surface to outer space. Most launch vehicles operate from a launch pad, launch pads, supported by a missile launch contro .... Up to this point, everything was going as planned. The impulse was also intended to ignite the escape motor. The motor was ignited, but it took a number of seconds to build up thrust, and thus the abort maneuver was not accomplished at the de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
