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BVDV
Bovine viral diarrhea (BVD), bovine viral diarrhoea (UK English) or mucosal disease, and previously referred to as bovine virus diarrhea (BVD), is an economically significant disease of cattle that is found in the majority of countries throughout the world. Worldwide reviews of the economically assessed production losses and intervention programs (e.g. eradication programs, vaccination strategies and biosecurity measures) incurred by BVD infection have been published. The causative agent, bovine viral diarrhea virus (BVDV), is a member of the genus ''Pestivirus'' of the family Flaviviridae. BVD infection results in a wide variety of clinical signs, due to its immunosuppressive effects, as well as having a direct effect on respiratory disease and fertility. In addition, BVD infection of a susceptible dam during a certain period of gestation can result in the production of a persistently infected (PI) fetus. PI animals recognise intra-cellular BVD viral particles as ‘self’ and ...
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Pestivirus G
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the positive strand RNA virus replication model. An IRES RNA element at the 5'-nontranslated region (NTR) of the viral genome recruits viral and cellular trans ...
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Pestivirus H
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the positive strand RNA virus replication model. An IRES RNA element at the 5'-nontranslated region (NTR) of the viral genome recruits viral and cellular trans ...
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Pestivirus
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the Positive-strand RNA virus, positive strand RNA virus replication model. An Internal ribosome entry site, IRES RNA element at the 5'-nontranslated region (NTR) ...
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Pestivirus K
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the positive strand RNA virus replication model. An IRES RNA element at the 5'-nontranslated region (NTR) of the viral genome recruits viral and cellular trans ...
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Pestivirus A
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the Positive-strand RNA virus, positive strand RNA virus replication model. An Internal ribosome entry site, IRES RNA element at the 5'-nontranslated region (NTR) ...
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Pestivirus B
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the positive strand RNA virus replication model. An IRES RNA element at the 5'-nontranslated region (NTR) of the viral genome recruits viral and cellular trans ...
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Pestivirus J
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the positive strand RNA virus replication model. An IRES RNA element at the 5'-nontranslated region (NTR) of the viral genome recruits viral and cellular trans ...
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Pestivirus I
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the positive strand RNA virus replication model. An IRES RNA element at the 5'-nontranslated region (NTR) of the viral genome recruits viral and cellular trans ...
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Pestivirus E
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the positive strand RNA virus replication model. An IRES RNA element at the 5'-nontranslated region (NTR) of the viral genome recruits viral and cellular trans ...
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Pestivirus F
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 11 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the positive strand RNA virus replication model. An IRES RNA element at the 5'-nontranslated region (NTR) of the viral genome recruits viral and cellular trans ...
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Border Disease
Border disease (BD) is a viral disease of sheep and goats, primarily causing congenital diseases, but can also cause acute and persistent infections. It first appeared in the border regions of England and Wales in 1959, and has since spread world-wide. Lambs that are born with BD are commonly known as 'hairy shakers' due to the primary presentation of the disease. The disease was recognized before the virus, therefore the common name of the disease predates the understanding of the viral pathology. The virus can cause a significant reduction in the percentage of surviving lambs, thus it has a large economic impact on farmers. Virus Border disease is caused by ''Pestivirus D'', also called simply "border disease virus" (BDV), in the family ''Flaviviridae''. It is the same virus causing the disease. It was given a scientific name in 2018 by the International Committee on Taxonomy of Viruses, after it had been identified. This virus is not host exclusive. It is noncytopathogenic -i ...
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Pestivirus D
Border disease (BD) is a viral disease of sheep and goats, primarily causing congenital diseases, but can also cause acute and persistent infections. It first appeared in the border regions of England and Wales in 1959, and has since spread world-wide. Lambs that are born with BD are commonly known as 'hairy shakers' due to the primary presentation of the disease. The disease was recognized before the virus, therefore the common name of the disease predates the understanding of the viral pathology. The virus can cause a significant reduction in the percentage of surviving lambs, thus it has a large economic impact on farmers. Virus Border disease is caused by ''Pestivirus D'', also called simply "border disease virus" (BDV), in the family ''Flaviviridae''. It is the same virus causing the disease. It was given a scientific name in 2018 by the International Committee on Taxonomy of Viruses, after it had been identified. This virus is not host exclusive. It is noncytopathogenic -i ...
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