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Box–Behnken Design
In statistics, Box–Behnken designs are experimental designs for response surface methodology, devised by George E. P. Box and Donald Behnken in 1960, to achieve the following goals: * Each factor, or independent variable, is placed at one of three equally spaced values, usually coded as −1, 0, +1. (At least three levels are needed for the following goal.) * The design should be sufficient to fit a quadratic model, that is, one containing squared terms, products of two factors, linear terms and an intercept. * The ratio of the number of experimental points to the number of coefficients in the quadratic model should be reasonable (in fact, their designs kept in the range of 1.5 to 2.6). * The efficiency (statistics), estimation variance should more or less depend only on the distance from the centre (this is achieved exactly for the designs with 4 and 7 factors), and should not vary too much inside the smallest (hyper)cube containing the experimental points. (See "rotatability" i ...
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Statistics
Statistics (from German language, German: ''wikt:Statistik#German, Statistik'', "description of a State (polity), state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of statistical survey, surveys and experimental design, experiments.Dodge, Y. (2006) ''The Oxford Dictionary of Statistical Terms'', Oxford University Press. When census data cannot be collected, statisticians collect data by developing specific experiment designs and survey sample (statistics), samples. Representative sampling as ...
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Experimental Design
The design of experiments (DOE, DOX, or experimental design) is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation. The term is generally associated with experiments in which the design introduces conditions that directly affect the variation, but may also refer to the design of quasi-experiments, in which natural conditions that influence the variation are selected for observation. In its simplest form, an experiment aims at predicting the outcome by introducing a change of the preconditions, which is represented by one or more independent variables, also referred to as "input variables" or "predictor variables." The change in one or more independent variables is generally hypothesized to result in a change in one or more dependent variables, also referred to as "output variables" or "response variables." The experimental design may also identify control variables that must be h ...
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Response Surface Methodology
In statistics, response surface methodology (RSM) explores the relationships between several explanatory variables and one or more response variables. The method was introduced by George E. P. Box and K. B. Wilson in 1951. The main idea of RSM is to use a sequence of designed experiments to obtain an optimal response. Box and Wilson suggest using a second-degree polynomial model to do this. They acknowledge that this model is only an approximation, but they use it because such a model is easy to estimate and apply, even when little is known about the process. Statistical approaches such as RSM can be employed to maximize the production of a special substance by optimization of operational factors. Of late, for formulation optimization, the RSM, using proper design of experiments (DoE), has become extensively used. In contrast to conventional methods, the interaction among process variables can be determined by statistical techniques. Basic approach of response surfa ...
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George E
George may refer to: People * George (given name) * George (surname) * George (singer), American-Canadian singer George Nozuka, known by the mononym George * George Washington, First President of the United States * George W. Bush, 43rd President of the United States * George H. W. Bush, 41st President of the United States * George V, King of Great Britain, Ireland, the British Dominions and Emperor of India from 1910-1936 * George VI, King of Great Britain, Ireland, the British Dominions and Emperor of India from 1936-1952 * Prince George of Wales * George Papagheorghe also known as Jorge / GEØRGE * George, stage name of Giorgio Moroder * George Harrison, an English musician and singer-songwriter Places South Africa * George, Western Cape ** George Airport United States * George, Iowa * George, Missouri * George, Washington * George County, Mississippi * George Air Force Base, a former U.S. Air Force base located in California Characters * George (Peppa Pig), a 2-year-ol ...
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Donald Behnken
Donald is a masculine given name derived from the Gaelic name ''Dòmhnall''.. This comes from the Proto-Celtic *''Dumno-ualos'' ("world-ruler" or "world-wielder"). The final -''d'' in ''Donald'' is partly derived from a misinterpretation of the Gaelic pronunciation by English speakers, and partly associated with the spelling of similar-sounding Germanic names, such as ''Ronald''. A short form of ''Donald'' is ''Don''. Pet forms of ''Donald'' include ''Donnie'' and ''Donny''. The feminine given name ''Donella'' is derived from ''Donald''. ''Donald'' has cognates in other Celtic languages: Modern Irish ''Dónal'' (anglicised as ''Donal'' and ''Donall'');. Scottish Gaelic ''Dòmhnall'', ''Domhnull'' and ''Dòmhnull''; Welsh '' Dyfnwal'' and Cumbric ''Dumnagual''. Although the feminine given name ''Donna'' is sometimes used as a feminine form of ''Donald'', the names are not etymologically related. Variations Kings and noblemen Domnall or Domhnall is the name of many ancie ...
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Quadratic Model
In algebra, a quadratic equation () is any equation that can be rearranged in standard form as ax^2 + bx + c = 0\,, where represents an unknown (mathematics), unknown value, and , , and represent known numbers, where . (If and then the equation is linear equation, linear, not quadratic.) The numbers , , and are the ''coefficients'' of the equation and may be distinguished by respectively calling them, the ''quadratic coefficient'', the ''linear coefficient'' and the ''constant'' or ''free term''. The values of that satisfy the equation are called ''solution (mathematics), solutions'' of the equation, and ''zero of a function, roots'' or ''zero of a function, zeros'' of the Expression (mathematics), expression on its left-hand side. A quadratic equation has at most two solutions. If there is only one solution, one says that it is a double root. If all the coefficients are real numbers, there are either two real solutions, or a single real double root, or two complex number, c ...
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Efficiency (statistics)
In statistics, efficiency is a measure of quality of an estimator, of an experimental design, or of a hypothesis testing procedure. Essentially, a more efficient estimator, needs fewer input data or observations than a less efficient one to achieve the Cramér–Rao bound. An ''efficient estimator'' is characterized by having the smallest possible variance, indicating that there is a small deviance between the estimated value and the "true" value in the L2 norm sense. The relative efficiency of two procedures is the ratio of their efficiencies, although often this concept is used where the comparison is made between a given procedure and a notional "best possible" procedure. The efficiencies and the relative efficiency of two procedures theoretically depend on the sample size available for the given procedure, but it is often possible to use the asymptotic relative efficiency (defined as the limit of the relative efficiencies as the sample size grows) as the principal compariso ...
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Factorial Design
In statistics, a full factorial experiment is an experiment whose design consists of two or more factors, each with discrete possible values or "levels", and whose experimental units take on all possible combinations of these levels across all such factors. A full factorial design may also be called a fully crossed design. Such an experiment allows the investigator to study the effect of each factor on the response variable, as well as the effects of interactions between factors on the response variable. For the vast majority of factorial experiments, each factor has only two levels. For example, with two factors each taking two levels, a factorial experiment would have four treatment combinations in total, and is usually called a ''2×2 factorial design''. In such a design, the interaction between the variables is often the most important. This applies even to scenarios where a main effect and an interaction is present. If the number of combinations in a full factorial design i ...
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Incomplete Block Design
In combinatorial mathematics, a block design is an incidence structure consisting of a set together with a family of subsets known as ''blocks'', chosen such that frequency of the elements satisfies certain conditions making the collection of blocks exhibit symmetry (balance). They have applications in many areas, including experimental design, finite geometry, physical chemistry, software testing, cryptography, and algebraic geometry. Without further specifications the term ''block design'' usually refers to a balanced incomplete block design (BIBD), specifically (and also synonymously) a 2-design, which has been the most intensely studied type historically due to its application in the design of experiments. Its generalization is known as a t-design. Overview A design is said to be ''balanced'' (up to ''t'') if all ''t''-subsets of the original set occur in equally many (i.e., ''λ'') blocks. When ''t'' is unspecified, it can usually be assumed to be 2, which means that ea ...
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Plackett–Burman Design
Plackett–Burman designs are experimental designs presented in 1946 by Robin L. Plackett and J. P. Burman while working in the British Ministry of Supply. Their goal was to find experimental designs for investigating the dependence of some measured quantity on a number of independent variables (factors), each taking ''L'' levels, in such a way as to minimize the variance of the estimates of these dependencies using a limited number of experiments. Interactions between the factors were considered negligible. The solution to this problem is to find an experimental design where ''each combination'' of levels for any pair of factors appears the ''same number of times'', throughout all the experimental runs (refer to table). A complete factorial design would satisfy this criterion, but the idea was to find smaller designs. For the case of two levels (''L'' = 2), Plackett and Burman used the method found in 1933 by Raymond Paley for generating orthogonal matrices whose eleme ...
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Central Composite Design
In statistics, a central composite design is an experimental design, useful in response surface methodology, for building a second order (quadratic) model for the response variable without needing to use a complete three-level factorial experiment. After the designed experiment is performed, linear regression is used, sometimes iteratively, to obtain results. Coded variables are often used when constructing this design. Implementation The design consists of three distinct sets of experimental runs: # A factorial design, factorial (perhaps Fractional factorial design, fractional) design in the factors studied, each having two levels; # A set of ''center points'', experimental runs whose values of each factor are the medians of the values used in the factorial portion. This point is often replicated in order to improve the precision of the experiment; # A set of ''axial points'', experimental runs identical to the centre points except for one factor, which will take on values both b ...
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