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Balo's Concentric Sclerosis
Baló's concentric sclerosis is a disease in which the white matter of the brain appears damaged in concentric layers, leaving the axis cylinder intact. It was described by József Mátyás Baló who initially named it "leuko-encephalitis periaxialis concentrica" from the previous definition, and it is currently considered one of the borderline forms of multiple sclerosis. Baló's concentric sclerosis is a demyelinating disease similar to standard multiple sclerosis, but with the particularity that the demyelinated tissues form concentric layers. Scientists used to believe that the prognosis was similar to Marburg multiple sclerosis, but now they know that patients can survive, or even have spontaneous remission and asymptomatic cases. The concentric ring appearance is not specific to Baló's MS. Concentric lesions have also been reported in patients with neuromyelitis optica, standard MS, progressive multifocal leukoencephalopathy, cerebral autosomal dominant arteriopathy with sub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
József Mátyás Baló
József Mátyás Baló (10 November 1895 – 9 October 1979) was a Hungarian physician and academic. He researched extensively into neurological conditions, cardiovascular conditions and with his wife isolated the enzyme elastase. He published numerous related papers and authored a medical book. He gave his name to Baló's Disease. Early life Born in Transylvania, the son of a minor noble, he graduated from Pázmány Péter Catholic University Medical School in 1919. He committed himself to pathology because at that time he wanted to work across the whole medical spectrum and this offered the best possibility. Career Following graduation he took a lifelong affiliation with the Pázmány Péter Catholic University Medical School in Budapest. He worked under Karoly Schaffer and Kalman Buday and at that juncture he concentrated on the pathology of the nervous system publishing some papers about changes in the nervous system in pernicious anaemia and periarteritis nodosa. In 1922 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caucasoid
The Caucasian race (also Caucasoid or Europid, Europoid) is an obsolete racial classification of human beings based on a now-disproven theory of biological race. The ''Caucasian race'' was historically regarded as a biological taxon which, depending on which of the historical race classifications was being used, usually included ancient and modern populations from all or parts of Europe, Western Asia, Central Asia, South Asia, North Africa, and the Horn of Africa. First introduced in the 1780s by members of the Göttingen school of history, the term denoted one of three purported major races of humankind (those three being Caucasoid, Mongoloid, and Negroid). In biological anthropology, ''Caucasoid'' has been used as an umbrella term for phenotypically similar groups from these different regions, with a focus on skeletal anatomy, and especially cranial morphology, without regard to skin tone. Ancient and modern "Caucasoid" populations were thus not exclusively "white", but rang ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Demyelinating Diseases Of CNS
Myelin is a lipid-rich material that surrounds nerve cell axons (the nervous system's "wires") to Insulator (electricity), insulate them and increase the rate at which electrical impulses (called action potentials) are passed along the axon. The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around it. However, unlike the plastic covering on an electrical wire, myelin does not form a single long sheath over the entire length of the axon. Rather, myelin sheaths the nerve in segments: in general, each axon is encased with multiple long myelinated sections with short gaps in between called node of Ranvier, nodes of Ranvier. Myelin is formed in the central nervous system (CNS; brain, spinal cord and optic nerve) by glial cells called oligodendrocytes and in the peripheral nervous system (PNS) by glial cells called Schwann cells. In the CNS, axons carry electrical signals from one nerve cell body to another. In the PNS, axons carry sig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumefactive Multiple Sclerosis
Tumefactive multiple sclerosis is a condition in which the central nervous system of a person has multiple demyelinating lesions with atypical characteristics for those of standard multiple sclerosis (MS). It is called tumefactive as the lesions are "tumor-like" and they mimic tumors clinically, radiologically and sometimes pathologically. These atypical lesion characteristics include a large intracranial lesion of size greater than 2.0 cm with a mass effect, edema and an open ring enhancement. A mass effect is the effect of a mass on its surroundings, for example, exerting pressure on the surrounding brain matter. Edema is the build-up of fluid within the brain tissue. Usually, the ring enhancement is directed toward the cortical surface.Kaeser, M. A., Scali, F., Lanzisera, F. P., Bub, G. A., and Kettner, N. W. Tumefactive multiple sclerosis: an uncommon diagnostic challenge. ''Journal of Chiropractic Medicine'' 10:29-35 (2011). The tumefactive lesion may mimic a malignant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Lesion Project
Multiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration, and tissue damage. The underlying cause is currently unknown. Current research in neuropathology, neuroimmunology, neurobiology, and neuroimaging, together with clinical neurology, provide support for the notion that MS is not a single disease but rather a spectrum. There are three clinical phenotypes: relapsing-remitting MS (RRMS), characterized by periods of neurological worsening following by remissions; secondary-progressive MS (SPMS), in which there is gradual progression of neurological dysfunction with fewer or no relapses; and primary-progressive MS (MS), in which neurological deterioration is observed from onset. Pathophysiology is a convergence of pathology with physiology. Pathology is the medical discipline that describes conditions typically observed during a disease state; whereas physio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multiple Sclerosis
Multiple (cerebral) sclerosis (MS), also known as encephalomyelitis disseminata or disseminated sclerosis, is the most common demyelinating disease, in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. Specific symptoms can include double vision, blindness in one eye, muscle weakness, and trouble with sensation or coordination. MS takes several forms, with new symptoms either occurring in isolated attacks (relapsing forms) or building up over time (progressive forms). In the relapsing forms of MS, between attacks, symptoms may disappear completely, although some permanent neurological problems often remain, especially as the disease advances. While the cause is unclear, the underlying mechanism is thought to be either destruction by the immune system ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Otto Marburg
Otto Marburg (May 25, 1874 – June 13, 1948) was an Austrian neurologist known for his contributions to the understanding of multiple sclerosis and for advances in neurooncology. Marburg was born in Römerstadt in Moravia, Austria-Hungary (today Rýmařov, Czech Republic). He was Jewish.Lewis P. Rowland, ''The legacy of Tracy J. Putnam and H. Houston Merritt: modern neurology in the United States'', Oxford University Press (2008), p. 62 From 1919 to 1938 he was head of the Neurological Institute at the University of Vienna. Following the 1938 Anschluss, Marburg was forced to emigrate to the United States as a refugee. Arriving in New York City, he joined Columbia University's College of Physicians and Surgeons as clinical professor of neurology. He was author of several standard texts about the nervous system, and a subtype of multiple sclerosis (Marburg multiple sclerosis) has been named after him. Marburg died of cancer in New York in 1948, at the age of 74. Otto Mar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fox News
The Fox News Channel, abbreviated FNC, commonly known as Fox News, and stylized in all caps, is an American multinational conservative cable news television channel based in New York City. It is owned by Fox News Media, which itself is owned by the Fox Corporation. The channel broadcasts primarily from studios at 1211 Avenue of the Americas in Midtown Manhattan. Fox News provides service to 86 countries and overseas territories worldwide, with international broadcasts featuring Fox Extra segments during ad breaks. The channel was created by Australian-American media mogul Rupert Murdoch in 1996 to appeal to a conservative audience, hiring former Republican media consultant and CNBC executive Roger Ailes as its founding CEO. It launched on October 7, 1996, to 17 million cable subscribers. Fox News grew during the late 1990s and 2000s to become the dominant United States cable news subscription network. , approximately 87,118,000 U.S. households (90.8% of television subscr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laboratory Mouse
The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets. Laboratory mice are usually of the species ''Mus musculus''. They are the most commonly used mammalian research model and are used for research in genetics, physiology, psychology, medicine and other scientific disciplines. Mice belong to the Euarchontoglires clade, which includes humans. This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. The laboratory mouse genome has been sequenced and many mouse genes have human homologues. Other mouse species sometimes used in laboratory research include two American species, the white-footed mouse (''Peromyscus leucopus'') and the North American deer mouse (''Peromyscus maniculatus''). History as a biological model Mice have been ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clostridium Perfringens
''Clostridium perfringens'' (formerly known as ''C. welchii'', or ''Bacillus welchii'') is a Gram-positive, rod-shaped, anaerobic, spore-forming pathogenic bacterium of the genus '' Clostridium''. ''C. perfringens'' is ever-present in nature and can be found as a normal component of decaying vegetation, marine sediment, the intestinal tract of humans and other vertebrates, insects, and soil. It has the shortest reported generation time of any organism at 6.3 minutes in thioglycolate medium. ''Clostridium perfringens'' is one of the most common causes of food poisoning in the United States, alongside norovirus, ''Salmonella'', '' Campylobacter'', and ''Staphylococcus aureus''. However, it can sometimes be ingested and cause no harm. Infections due to ''C. perfringens'' show evidence of tissue necrosis, bacteremia, emphysematous cholecystitis, and gas gangrene, also known as clostridial myonecrosis. The specific name ''perfringens'' is derived from the Latin ''per'' (meaning " ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aquaporin-1
Aquaporin 1 (AQP-1) is a protein that in humans is encoded by the ''AQP1'' gene. AQP-1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, lungs, and the central nervous system. Neural AQP-1 receptors are regulated by vasopressin AVPR1A receptor activity. Function Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein ( MIP or AQP0). This gene encodes an aquaporin which functions as both a molecular water channel protein and as a non-selective cation channel gated by cyclic guanosine monophosphate (cGMP). It is a homotetramer with six bilayer spanning domains and N-glycosylation site ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plasmapheresis
Plasmapheresis (from the Greek πλάσμα, ''plasma'', something molded, and ἀφαίρεσις ''aphairesis'', taking away) is the removal, treatment, and return or exchange of blood plasma or components thereof from and to the blood circulation. It is thus an extracorporeal therapy, a medical procedure performed outside the body. Three general types of plasmapheresis can be distinguished: * ''Autologuous'', removing blood plasma, treating it in some way, and returning it to the same person, as a therapy. * ''Exchange'', a patient's blood plasma is removed, while blood products are given in replacement. This type is called plasma exchange (PE, PLEX, or PEX) or plasma exchange therapy (PET). The removed plasma is discarded and the patient receives replacement donor plasma, albumin, or a combination of albumin and saline (usually 70% albumin and 30% saline). * ''Donation'', removing blood plasma, separating its components, and returning some of them to the same person, while ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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