Arnold J. Levine
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Arnold J. Levine
Arnold Jay Levine (born 1939), is an American Molecular biologist. He was awarded the 1998 Louisa Gross Horwitz Prize for Biology or Biochemistry and was the first recipient of the Albany Medical Center Prize in Medicine and Biomedical Research in 2001 for his discovery of the tumor suppressor protein p53. He is currently Professor Emeritus of Systems Biology at the Institute for Advanced Study in Princeton, New Jersey. Career Levine received his Ph.D. from the University of Pennsylvania in 1966. Levine discovered, with several colleagues, the p53 tumor suppressor gene in 1979, a protein involved in cell cycle regulation, and one of the most frequently mutated genes in human cancer, in work done as a professor in the biochemistry department at Princeton University. In 1979 Levine moved to become Chairman of the Department of Microbiology at Stony Brook School of Medicine before moving back to Princeton in 1984. In 1998 Levine became the Robert and Harriet Heilbrunn Professo ...
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Rockefeller University
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified among "R2: Doctoral Universities – High research activity." Rockefeller is the oldest biomedical research institute in the United States. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, seven Lasker Award recipients, and five Nobel laureates. As of March 2022, a total of 26 Nobel laureates have been affiliated with Rockefeller University. The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the ''Journal of Experimental Medicine' ...
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Keio Medical Science Prize
The Keio Medical Science Prize (Japanese: 慶應医学賞) is a Japanese prize in medical sciences. Introduction The prize is awarded to scientists who made significant contributions to the field of medical sciences or life sciences. And these contributions can further promote the peace and prosperity of mankind and human society.The Keio Medical Science Prize
The prize award is 20 million (approximately 180,000 ). A is also awarded to the winner. E ...
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Institute Of Medicine
The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Sciences (NAS), National Academy of Engineering (NAE), and the National Research Council (NRC). The National Academy of Medicine provides national and international advice on issues relating to health, medicine, health policy, and biomedical science. It aims to provide unbiased, evidence-based, and authoritative information and advice concerning health and science policy to policy-makers, professionals, leaders in every sector of society, and the public at large. Operating outside the framework of the U.S. federal government, it relies on a volunteer workforce of scientists and other experts, operating under a formal peer-review system. As a national academy, the organization a ...
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Albany Medical Center Prize
The Albany Medical Center Prize in Medicine and Biomedical Research is the United States' second highest value prize in medicine and biomedical research, awarded by the Albany Medical Center. Among prizes for medicine worldwide, the Albany Medical Center Prize is the fourth most lucrative (after the $3 million Breakthrough Prize in Life Sciences, the $1.2 million Nobel Prize in Medicine and the $1 million Shaw Prize in life science and medicine). Awarded annually, the $500,000 prize is bestowed to any physician or scientist, or group, whose work has led to significant advances in the fields of health care and scientific research with demonstrated translational benefits applied to improved patient care. The prize is a legacy to its founder, the late Morris "Marty" Silverman. At the inaugural awards ceremony in Albany, NY in March 2001, Silverman started a tradition that will be carried on for one hundred years, the duration of the Prize. Silverman's promise was to light one candle ...
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Columbia University
Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhattan, Columbia is the oldest institution of higher education in New York and the fifth-oldest institution of higher learning in the United States. It is one of nine colonial colleges founded prior to the Declaration of Independence. It is a member of the Ivy League. Columbia is ranked among the top universities in the world. Columbia was established by royal charter under George II of Great Britain. It was renamed Columbia College in 1784 following the American Revolution, and in 1787 was placed under a private board of trustees headed by former students Alexander Hamilton and John Jay. In 1896, the campus was moved to its current location in Morningside Heights and renamed Columbia University. Columbia scientists and scholars have ...
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Louisa Gross Horwitz Prize
The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemistry. The prize was established at the bequest of S. Gross Horwitz and is named to honor his mother, Louisa Gross Horwitz, the daughter of trauma surgeon Samuel D. Gross. The prize was first awarded in 1967. As of October 2018, 51 (50%) of the 101 prize recipients have subsequently been awarded the Nobel Prize in Physiology or Medicine (40) or Chemistry (11). It is regarded as one of the important precursors of a future Nobel Prize award. Recipients *1967 Luis Leloir (1970 Chemistry) *1968 Har Gobind Khorana (1968 Physiology or Medicine), Marshall Warren Nirenberg (1968 Physiology or Medicine) *1969 Max Delbrück (1969 Physiology or Medicine), Salvador E. Luria (1969 Physiology or Medicine) *1970 Albert Claude (1974 Physiology or Medicine ...
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Robert Wood Johnson Medical School
Rutgers Robert Wood Johnson Medical School is a medical school of Rutgers University. It is one of the two graduate medical schools of Rutgers Biomedical and Health Sciences, together with New Jersey Medical School, and is closely aligned with Robert Wood Johnson University Hospital, the medical school's principal affiliate. Rutgers Robert Wood Johnson Medical School operates campuses in Piscataway and New Brunswick in New Jersey. The medical school includes 20 basic science and clinical departments and a broad range of clinical programs conducted at its 34 hospital affiliates and numerous ambulatory care sites in the region. The school is named after Robert Wood Johnson II, the former president and chairman of the board of Johnson & Johnson. Prior to July 2013, Robert Wood Johnson Medical School was part of the University of Medicine and Dentistry of New Jersey (UMDNJ). In 2015-16 admissions cycle, the medical school has introduced the CASPer test, developed by McMaster Universi ...
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Stony Brook School Of Medicine
The Renaissance School of Medicine (RSOM) is the graduate medical school of Stony Brook University located in the hamlet of Stony Brook on Long Island, New York. Founded in 1971, RSOM is consistently ranked the top public medical school in New York according to '' U.S. News & World Report''. RSOM is one of the five Health Sciences schools under thStony Brook Medicinehealthcare system. RSOM conducts $90 million in funded medical research annually, with NIH awards to RSOM faculty and research centers exceeding $42 million. Stony Brook University Hospital, RSOM's main clinical training site, is ranked the No. 10 best hospital in New York State. History In 1963, Governor Nelson Rockefeller commissioned the report “Education of Health Professions,” also known as the Muir Report. This document recommended the creation of a Health Sciences Center and an academic hospital to serve the need of the fastest growing counties in New York at the time, Nassau and Suffolk. In response ...
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Princeton University
Princeton University is a private university, private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest institution of higher education in the United States and one of the nine colonial colleges chartered before the American Revolution. It is one of the highest-ranked universities in the world. The institution moved to Newark, New Jersey, Newark in 1747, and then to the current site nine years later. It officially became a university in 1896 and was subsequently renamed Princeton University. It is a member of the Ivy League. The university is governed by the Trustees of Princeton University and has an endowment of $37.7 billion, the largest List of colleges and universities in the United States by endowment, endowment per student in the United States. Princeton provides undergraduate education, undergraduate and graduate education, graduate in ...
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Cell Cycle
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and subsequently the partitioning of its cytoplasm, chromosomes and other components into two daughter cells in a process called cell division. In cells with nuclei ( eukaryotes, i.e., animal, plant, fungal, and protist cells), the cell cycle is divided into two main stages: interphase and the mitotic (M) phase (including mitosis and cytokinesis). During interphase, the cell grows, accumulating nutrients needed for mitosis, and replicates its DNA and some of its organelles. During the mitotic phase, the replicated chromosomes, organelles, and cytoplasm separate into two new daughter cells. To ensure the proper replication of cellular components and division, there are control mechanisms known as cell cycle checkpoints after each of the key steps ...
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Tumor Suppressor Gene
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or reduction in its function. In combination with other genetic mutations, this could allow the cell to grow abnormally. The loss of function for these genes may be even more significant in the development of human cancers, compared to the activation of oncogenes. TSGs can be grouped into the following categories: caretaker genes, gatekeeper genes, and more recently landscaper genes. Caretaker genes ensure stability of the genome via DNA repair and subsequently when mutated allow mutations to accumulate. Meanwhile, gatekeeper genes directly regulate cell growth by either inhibiting cell cycle progression or inducing apoptosis. Lastly landscaper genes regulate growth by contributing to the surrounding environment, when mutated can cause an envir ...
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ProQuest
ProQuest LLC is an Ann Arbor, Michigan-based global information-content and technology company, founded in 1938 as University Microfilms by Eugene B. Power. ProQuest is known for its applications and information services for libraries, providing access to dissertations, theses, ebooks, newspapers, periodicals, historical collections, governmental archives, cultural archives,"Jisc and ProQuest Enable Access to Essential Digital Content"
retrieved May 21, 2014
and other aggregated databases. This content was estimated to be around 125 billion digital pages, ...
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