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Arne Holmgren (ice Hockey)
Arne Holmgren (21 December 1940 — 6 January 2020) was a Swedish biochemist known as a redox pioneer. He studied medicine at Uppsala University in 1962 and became a medical student. He received his Ph.D. in 1968 from the Karolinska Institute (KI) where he became associate professor in 1969, and became a certified doctor in 1974. In the years 1970-1973, Holmgren was a senior lecturer in medical chemistry and 1973-1982 a research lecturer and assistant professor of medical chemistry. He was appointed professor of medical protein chemistry and enzymology at KI in 1983, and in 1991 professor of biochemistry and director of the Department of Biochemistry at the Medical Nobel Institute, KI. Holmgren's research pioneered the structure and function of thioredoxin and thioredoxin reductase and discovered glutaredoxins. His investigations clarified basic sulphur and selenium-dependent redox mechanisms crucial for DNA synthesis, defence against oxidative stress and redox signalling i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Södermanland
Södermanland ( or ), locally Sörmland, sometimes referred to under its Latin form ''Sudermannia'' or ''Sudermania'', is a historical province or ''landskap'' on the south eastern coast of Sweden. It borders Östergötland, Närke, Västmanland and Uppland. It is also bounded by lake Mälaren and the Baltic Sea. Södermanland means "(The) Land of the Southern Men", where the "southern men" (''södermännen'') were the people living south of Uppland. Administration The traditional provinces of Sweden serve no administrative or political purposes, but are historical and cultural entities. There is a corresponding administrative Södermanland County. However, the bulk of the population is within Stockholm County. Heraldry The coat of arms was granted in 1560. The arms is represented with a ducal coronet. Blazon: "Or, a Griffin rampant Sable beaked, langued, membered and armed Gules." The same CoA was granted for the county in 1940. Geography Södermanland is situated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxidative Stress
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily Detoxification, detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Oxidative stress from Cellular respiration, oxidative metabolism causes base damage, as well as DNA damage (naturally occurring), strand breaks in DNA. Base damage is mostly indirect and caused by the reactive oxygen species generated, e.g., O2− (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide). Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. In humans, oxidative stress is thought to be involved in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academic Staff Of The Karolinska Institute
An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary or tertiary higher learning (and generally also research or honorary membership). The name traces back to Plato's school of philosophy, founded approximately 385 BC at Akademia, a sanctuary of Athena, the goddess of wisdom and skill, north of Athens, Greece. Etymology The word comes from the ''Academy'' in ancient Greece, which derives from the Athenian hero, ''Akademos''. Outside the city walls of Athens, the gymnasium was made famous by Plato as a center of learning. The sacred space, dedicated to the goddess of wisdom, Athena, had formerly been an olive grove, hence the expression "the groves of Academe". In these gardens, the philosopher Plato conversed with followers. Plato developed his sessions into a method of teaching philosophy and in 387 BC, established what is known today as the Old Academy. By extension, ''academia'' has come to mean the accumulation, dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2020 Deaths
This is a list of deaths of notable people, organised by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked here. 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 See also * Lists of deaths by day The following pages, corresponding to the Gregorian calendar, list the historical events, births, deaths, and holidays and observances of the specified day of the year: Footnotes See also * Leap year * List of calendars * List of non-standard ... * Deaths by year {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1940 Births
Year 194 ( CXCIV) was a common year starting on Tuesday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Septimius and Septimius (or, less frequently, year 947 ''Ab urbe condita''). The denomination 194 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Emperor Septimius Severus and Decimus Clodius Septimius Albinus Caesar become Roman Consuls. * Battle of Issus: Septimius Severus marches with his army (12 legions) to Cilicia, and defeats Pescennius Niger, Roman governor of Syria. Pescennius retreats to Antioch, and is executed by Severus' troops. * Septimius Severus besieges Byzantium (194–196); the city walls suffer extensive damage. Asia * Battle of Yan Province: Warlords Cao Cao and Lü Bu fight for control over Yan Province; the battle lasts for over 100 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swedish Biochemists
Swedish or ' may refer to: Anything from or related to Sweden, a country in Northern Europe. Or, specifically: * Swedish language, a North Germanic language spoken primarily in Sweden and Finland ** Swedish alphabet, the official alphabet used by the Swedish language * Swedish people or Swedes, persons with a Swedish ancestral or ethnic identity ** A national or citizen of Sweden, see demographics of Sweden ** Culture of Sweden * Swedish cuisine See also * * Swedish Church (other) * Swedish Institute (other) * Swedish invasion (other) * Swedish Open (other) Swedish Open is a tennis tournament. Swedish Open may also refer to: *Swedish Open (badminton) * Swedish Open (table tennis) *Swedish Open (squash) *Swedish Open (darts) The Swedish Open is a darts tournament established in 1969, held in Malmà ... {{disambig Language and nationality disambiguation pages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roland Stocker
Roland Stocker (born 5 October 1956 in Switzerland) is a Swiss Australian biochemist who discovered the antioxidant activity of bilirubin. He is a former Olympic rower and has represented Switzerland at the 1980 Summer Olympics. Early life and education Stocker was awarded a ''Diplom mNaturwissenschaften und Mathematik'' (Dipl. Natw.), or Diploma in/of Natural Science, from the ETH Zurich in 1981 and a Ph.D. from the Australian National University in 1985. Career Stocker has made significant contributions to the understanding of the molecular action of Alpha-Tocopherol (vitamin E) during the oxidation of lipoproteins, the antioxidant activities of ubiquinol-10 in lipoproteins, the contribution of oxidation of low-density lipoprotein to atherosclerosis, the understanding of how antioxidants and heme oxygenase-1 protect against atherosclerosis, the role of myeloperoxidase to atherosclerotic plaque destabilization, and the contribution of tryptophan metabolism by indoleamine 2, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Assembly At The Karolinska Institute
The Nobel Assembly at the Karolinska Institute is a body at Karolinska Institute which awards the Nobel Prize in Physiology or Medicine. It is headquartered in the Nobel Forum on the grounds of the Karolinska Institute campus. Originally the Nobel Assembly was not a formal body but rather the collective of all professors (holders of chairs, i.e. full professors) at Karolinska Institute. In 1977 the Nobel Assembly became a separate private organization hosted by Karolinska Institute. Until 1984 all Karolinska Institute professors belonged to the Assembly; from 1984 the membership is restricted to 50 Karolinska Institute professors.Karolinska Institutet: ''Nobelpriset - den ärofyllda traditionen'' accessed on August 3, 2009 The main work involved in collecting nominations and screening no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Synthesis
DNA synthesis is the natural or artificial creation of deoxyribonucleic acid (DNA) molecules. DNA is a macromolecule made up of nucleotide units, which are linked by covalent bonds and hydrogen bonds, in a repeating structure. DNA synthesis occurs when these nucleotide units are joined to form DNA; this can occur artificially (''in vitro'') or naturally (''in vivo''). Nucleotide units are made up of a nitrogenous base (cytosine, guanine, adenine or thymine), pentose sugar (deoxyribose) and phosphate group. Each unit is joined when a covalent bond forms between its phosphate group and the pentose sugar of the next nucleotide, forming a sugar-phosphate backbone. DNA is a complementary, double stranded structure as specific base pairing (adenine and thymine, guanine and cytosine) occurs naturally when hydrogen bonds form between the nucleotide bases. There are several different definitions for DNA synthesis: it can refer to DNA replication - DNA biosynthesis (''in vivo'' DNA amplific ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sweden
Sweden, formally the Kingdom of Sweden,The United Nations Group of Experts on Geographical Names states that the country's formal name is the Kingdom of SwedenUNGEGN World Geographical Names, Sweden./ref> is a Nordic country located on the Scandinavian Peninsula in Northern Europe. It borders Norway to the west and north, Finland to the east, and is connected to Denmark in the southwest by a bridgetunnel across the Öresund. At , Sweden is the largest Nordic country, the third-largest country in the European Union, and the fifth-largest country in Europe. The capital and largest city is Stockholm. Sweden has a total population of 10.5 million, and a low population density of , with around 87% of Swedes residing in urban areas in the central and southern half of the country. Sweden has a nature dominated by forests and a large amount of lakes, including some of the largest in Europe. Many long rivers run from the Scandes range through the landscape, primarily ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glutaredoxin
Glutaredoxins (also known as Thioltransferase) are small redox enzymes of approximately one hundred amino-acid residues that use glutathione as a cofactor. In humans this oxidation repair enzyme is also known to participate in many cellular functions, including redox signaling and regulation of glucose metabolism. Glutaredoxins are oxidized by substrates, and reduced non-enzymatically by glutathione. In contrast to thioredoxins, which are reduced by thioredoxin reductase, no oxidoreductase exists that specifically reduces glutaredoxins. Instead, glutaredoxins are reduced by the oxidation of glutathione. Reduced glutathione is then regenerated by glutathione reductase. Together these components compose the glutathione system. Like thioredoxin, which functions in a similar way, glutaredoxin possesses an active centre disulfide bond. It exists in either a reduced or an oxidized form where the two cysteine residues are linked in an intramolecular disulfide bond. Glutaredoxins function ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thioredoxin Reductase
Thioredoxin reductases (TR, TrxR) () are enzymes that reduce thioredoxin (Trx). Two classes of thioredoxin reductase have been identified: one class in bacteria and some eukaryotes and one in animals. In bacteria TrxR also catalyzes the reduction of glutaredoxin like proteins known as NrdH. Both classes are flavoproteins which function as homodimers. Each monomer contains a FAD prosthetic group, a NADPH binding domain, and an active site containing a redox-active disulfide bond. Cellular role Thioredoxin reductases are enzymes that catalyze the reduction of thioredoxin and hence they are a central component in the thioredoxin system. Together with thioredoxin (Trx) and NADPH this system's most general description is as a system for reducing disulfide bonds in cells. Electrons are taken from NADPH via TrxR and are transferred to the active site of Trx, which goes on to reduce protein disulfides or other substrates. The Trx system exists in all living cells and has an evolutiona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
