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Angela Brodie
Angela Hartley Brodie (28 September 1934 – 7 June 2017) was a British biochemist who pioneered development of steroidal aromatase inhibitors in cancer research. Born in Lancashire (now Greater Manchester), Brodie studied chemical pathology to a doctoral level in Sheffield and was awarded a fellowship sponsored by National Institutes of Health. After 17 years of working in Shrewsbury, Massachusetts on oral contraceptives with Harry Brodie, whom she married, she switched focus to the effects of the oestrogen-producing enzyme, aromatase, on breast cancer. Brodie managed to get an aromatase inhibitor into a limited clinical trial in breast cancer patients in London, which had such a profound effect that it led to Novartis-sponsored trials, the development of formestane, the first aromatase inhibitor, eventually marketed in 1994. Brodie's work has been hailed "as among the most important contributions to cancer cure." Early life and education Brodie was born Angela Hartley on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oldham
Oldham is a large town in Greater Manchester, England, amid the Pennines and between the rivers Irk and Medlock, southeast of Rochdale and northeast of Manchester. It is the administrative centre of the Metropolitan Borough of Oldham, which had a population of 237,110 in 2019. Within the boundaries of the historic county of Lancashire, and with little early history to speak of, Oldham rose to prominence in the 19th century as an international centre of textile manufacture. It was a boomtown of the Industrial Revolution, and among the first ever industrialised towns, rapidly becoming "one of the most important centres of cotton and textile industries in England." At its zenith, it was the most productive cotton spinning mill town in the world,. producing more cotton than France and Germany combined. Oldham's textile industry fell into decline in the mid-20th century; the town's last mill closed in 1998. The demise of textile processing in Oldham depressed and heavily ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quaker
Quakers are people who belong to a historically Protestant Christian set of Christian denomination, denominations known formally as the Religious Society of Friends. Members of these movements ("theFriends") are generally united by a belief in each human's ability to experience Inward light, the light within or see "that of God in every one". Some profess a priesthood of all believers inspired by the First Epistle of Peter. They include those with evangelicalism, evangelical, Holiness movement, holiness, Mainline Protestant, liberal, and Conservative Friends, traditional Quaker understandings of Christianity. There are also Nontheist Quakers, whose spiritual practice does not rely on the existence of God. To differing extents, the Friends avoid creeds and Hierarchical structure, hierarchical structures. In 2017, there were an estimated 377,557 adult Quakers, 49% of them in Africa. Some 89% of Quakers worldwide belong to ''evangelical'' and ''programmed'' branches that hold ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornelia Channing
Cornelia "Nina" Channing (1938–1985) was an American professor of physiology at the University of Maryland School of Medicine. Her research focused on endocrinology and fertility; along with longtime collaborators Neena Schwartz and Darrell Ward, she was involved in the discovery of hormones involved in regulating the female reproductive cycle. She died of breast cancer in 1985. Early life and education Channing was born in Boston, Massachusetts in 1938. She received her bachelor's degree from Hood College in 1961 and her PhD in biochemistry from Harvard Medical School in 1965, advised by Claude Villee. She worked as a postdoctoral fellow in Cambridge. Academic career Channing returned to the US to serve as an instructor and later an assistant professor at the University of Pittsburgh, where she spent seven years in total. In 1973 she moved to the University of Maryland as an associate professor and was promoted to full professor in 1976. Channing served on the board of direc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroidal Aromatase Inhibitor
Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in breast tissue increases the risk of developing breast cancer and the enzyme aromatase is considered to be a good Biological target, therapeutic target when treating breast cancer due to it being involved in the final step of estrogen biosynthetic pathway and also its inhibition will not affect production of other steroids. Aromatase Inhibitors are classified into two categories based on their structure, nonsteroidal and steroidal; the latter resemble the structure of 4-Androstenedione, androstenedione. Steroidal aromatase inhibitors irreversibly inhibit the enzyme by binding covalently to the binding site of aromatase so the substrate cannot access it. History Collaboration leading to discovery In 1944 the Worcester Foundation for Biomedical Research, Worcester Foundation for Experimental Biology (WFEB) was established. The foundati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harold Brodie
Harold may refer to: People * Harold (given name), including a list of persons and fictional characters with the name * Harold (surname), surname in the English language * András Arató, known in meme culture as "Hide the Pain Harold" Arts and entertainment * ''Harold'' (film), a 2008 comedy film * ''Harold'', an 1876 poem by Alfred, Lord Tennyson * ''Harold, the Last of the Saxons'', an 1848 book by Edward Bulwer-Lytton, 1st Baron Lytton * ''Harold or the Norman Conquest'', an opera by Frederic Cowen * ''Harold'', an 1885 opera by Eduard Nápravník * Harold, a character from the cartoon ''The Grim Adventures of Billy & Mandy'' * Harold & Kumar, a US movie; Harold/Harry is the main actor in the show. Places ;In the United States * Alpine, Los Angeles County, California, an erstwhile settlement that was also known as Harold * Harold, Florida, an unincorporated community * Harold, Kentucky, an unincorporated community * Harold, Missouri, an unincorporated community ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oral Contraceptive Pill
Oral contraceptives, abbreviated OCPs, also known as birth control pills, are medications taken by mouth for the purpose of birth control. Female Two types of female oral contraceptive pill, taken once per day, are widely available: * The combined oral contraceptive pill contains estrogen and a progestin. Colloquially known as "The Pill". * The progestogen-only pill, colloquially known as "minipill". * Ormeloxifene is a selective estrogen receptor modulator which offers the benefit of only having to be taken once a week. Emergency contraception pills ("morning after pills") are taken at the time of intercourse, or within a few days afterwards: * Levonorgestrel, sold under the brand name Plan B * Ulipristal acetate * Mifepristone and misoprostol, when used in combination, are more than 95% effective during the first 50 days of pregnancy. Male * Male oral contraceptive Male contraceptives, also known as male birth control, are methods of preventing pregnancy that solely invol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brandeis University
, mottoeng = "Truth even unto its innermost parts" , established = , type = Private research university , accreditation = NECHE , president = Ronald D. Liebowitz , provost = Carol Fierke , city = Waltham , state = Massachusetts , country = United States , endowment = $1.07 billion (2019) , students = 5,458 (2021) , undergrad = 3,591 (2021) , postgrad = 1,967 (2021) , faculty = 544 (2021) , administrative_staff = 1,314 (2021) , campus = Small City, , mascot = The Judge and Ollie the Owl (named for Justice Oliver Wendell Holmes Jr.) , sports_nickname = Judges , colors = Brandeis Blue , athletics_affiliations = , academic_affiliations = , website = , logo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clark University
Clark University is a private research university in Worcester, Massachusetts. Founded in 1887 with a large endowment from its namesake Jonas Gilman Clark, a prominent businessman, Clark was one of the first modern research universities in the United States. Originally an all-graduate institution, Clark's first undergraduates entered in 1902 and women were first enrolled in 1942. The university now offers 46 majors, minors, and concentrations in the humanities, social sciences, natural sciences, and engineering and allows students to design specialized majors and engage in pre-professional programs. It is noted for its programs in the fields of psychology, geography, physics, biology, and entrepreneurship and is a member of the Higher Education Consortium of Central Massachusetts which enables students to cross-register to attend courses at other area institutions including Worcester Polytechnic Institute and the College of the Holy Cross. As a liberal arts–based research uni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aldosterone
Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays a central role in the homeostatic regulation of blood pressure, plasma sodium (Na+), and potassium (K+) levels. It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron. It influences the reabsorption of sodium and excretion of potassium (from and into the tubular fluids, respectively) of the kidney, thereby indirectly influencing water retention or loss, blood pressure, and blood volume.Marieb Human Anatomy & Physiology 9th edition, chapter:16, page:629, question number:14 When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and kidney disease. Aldosterone has exactly the opposite function of the atrial natriure ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Manchester
, mottoeng = Knowledge, Wisdom, Humanity , established = 2004 – University of Manchester Predecessor institutions: 1956 – UMIST (as university college; university 1994) 1904 – Victoria University of Manchester 1880 – Victoria University 1851 – Owens College 1824 – Manchester Mechanics' Institute , endowment = £242.2 million (2021) , budget = £1.10 billion (2020–21) , chancellor = Nazir Afzal (from August 2022) , head_label = President and vice-chancellor , head = Nancy Rothwell , academic_staff = 5,150 (2020) , total_staff = 12,920 (2021) , students = 40,485 (2021) , undergrad = () , postgrad = () , city = Manchester , country = England, United Kingdom , campus = Urban and suburban , colours = Manchester Purple Manchester Yellow , free_label = Scarf , free = , website = , logo = UniOfManchesterLogo.svg , affiliations = Universities Research Association Sutton 30 Russell Group EUA N8 Group NWUA ACUUniversities UK The Universit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Estrogen-dependent Condition
An estrogen-dependent condition can be that relating to the differentiation in the steroid sex hormone that is associated with the female reproductive system and sex characteristics. These conditions can fall under the umbrella of hypoestrogenism, hyperestrogenim, or any sensitivity to the presence of estrogen in the body. Estrogen Estrogen is a critical sex hormone for women (in conjunction with progesterone). Estrogen is responsible for all different functions in a female body, but is also seen in any gender. These functions are seen in body tracts such as the skeletal system, liver, brain and breasts. There are three different formulations of estrogen: estrone, estradiol, and estriol.These are commonly referred to as E1, E2, and E3, following the listing stated prior. These three formulations have different functions in a women's life. Estradiol (E2) is seen in the reproductive time period. Estriol (E3) is seen primarily during pregnancy. Finally, estrone (E1) is the form t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christie Hospital
The Christie Hospital in Manchester, England, is one of the largest cancer treatment centres in Europe. It is managed by The Christie NHS Foundation Trust. History The hospital was established by a committee under the chairmanship of Richard Christie, a lawyer and academic, as the Cancer Pavilion and Home for Incurables. It opened at a site in Lorne Street off Oxford Road in 1892, at a site in Chorlton-upon-Medlock now occupied by Manchester Royal Infirmary. The name of the pavilion was changed by the addition of "Christie" in 1901 after Christie himself had died. In 1929 it had 34 beds and was resorted to by patients from northern England and north Wales; it was then the only provincial hospital solely for cancer treatment. Associated with it was the Radium Institute (founded in 1914, which moved to Nelson Street in 1921). In 1928, the hospital had 14 beds, 374 in-patients and over 7,000 out-patients who were given radium treatment. Together with the Holt Institute, the Christ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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