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Andrea Pauli
Andrea Pauli (born 1977) is a developmental biologist and biochemist studying how the egg transitions into an embryo, and more specifically the molecular mechanisms underlying vertebrate fertilisations, egg dormancy, and subsequent egg activation. Her lab uses zebrafish as the main model organism. Andrea Pauli is a group leader at the Research Institute of Molecular Pathology (IMP) at the Vienna Biocenter in Austria. Early life and education Andrea Pauli grew up in Bavaria, Germany. She studied biochemistry at Regensburg University, followed by a master’s in molecular and cellular biology at Heidelberg University. In 2004, she started her doctoral research under the joint supervision of Barry Dickson and Kim Nasmyth at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria. When Nasmyth transferred to the University of Oxford in 2006, Pauli moved with him and obtained her PhD from Oxford in 2009. As a student, she competed twice in the Oxford-Cambri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Institute Of Molecular Pathology
The Research Institute of Molecular Pathology (IMP) is a biomedical research center, which conducts curiosity-driven basic research in the molecular life sciences. The IMP is located at the Vienna Biocenter in Vienna, Austria. The institute employs around 270 people from 40 countries, of which over 200 are scientists. The working language at the IMP is English. The IMP was established in 1985 and is funded by the pharmaceutical company Boehringer Ingelheim and research grants. Research IMP comprises 15 independent research groups performing basic biological research across the following areas: * molecular and cellular biology; * structural biology and biochemistry; * gene expression and chromosome biology; * stem cell biology and development; * immunology and cancer; * neuroscience. Publications, awards and honours Scientists at the IMP publish 60 to 90 papers in international peer-review journals per year: between 1985 and 2021, more than 2,200 research papers were published. 9 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vienna Biocenter
The Vienna BioCenter is a cluster of life science research institutes and biotechnology companies located in the 3rd municipal District of Vienna, Austria. It grew around the Research Institute of Molecular Pathology (IMP), which opened in 1988. The entities at the Vienna BioCenter employ more than 2,000 people, including 600 students. Structure As of 2020, the Vienna BioCenter is an association of 4 research institutes, 38 biotech companies, 1 outreach organisation, 4 service companies and 2 business incubators. The four basic research institutes are the Research Institute of Molecular Pathology (IMP), the Max Perutz Labs of the University of Vienna and Medical University of Vienna, the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences (ÖAW), and the Gregor Mendel Institute of Molecular Plant Biology (GMI), also of the ÖAW. These institutes maintain a joint international PhD programme. TheVienna BioCenter Core Facilities (VBCF) offer c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A polypeptide is a longer, continuous, unbranched peptide chain. Hence, peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. A polypeptide that contains more than approximately 50 amino acids is known as a protein. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila Melanogaster
''Drosophila melanogaster'' is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly, or less commonly the "vinegar fly" or "pomace fly". Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, ''D. melanogaster'' continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. As of 2017, five Nobel Prizes have been awarded to drosophilists for their work using the insect. ''D. melanogaster'' is typically used in research owing to its rapid life cycle, relatively simple genetics with only four pairs of chromosomes, and large number of offspring per generation. It was originally an African species, with all non-African lineages having a common origin. Its geographic range includes all continents, including islands. ''D. melanogaster'' is a common pest in homes, restaurants, and othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Division
Cell division is the process by which a parent cell (biology), cell divides into two daughter cells. Cell division usually occurs as part of a larger cell cycle in which the cell grows and replicates its chromosome(s) before dividing. In eukaryotes, there are two distinct types of cell division: a vegetative division (mitosis), producing daughter cells genetically identical to the parent cell, and a cell division that produces Haploidisation, haploid gametes for sexual reproduction (meiosis), reducing the number of chromosomes from two of each type in the diploid parent cell to one of each type in the daughter cells. In cell biology, mitosis (Help:IPA/English, /maɪˈtoʊsɪs/) is a part of the cell cycle, in which, replicated chromosomes are separated into two new Cell nucleus, nuclei. Cell division gives rise to genetically identical cells in which the total number of chromosomes is maintained. In general, mitosis (division of the nucleus) is preceded by the S stage of interph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromatid
A chromatid (Greek ''khrōmat-'' 'color' + ''-id'') is one half of a duplicated chromosome. Before replication, one chromosome is composed of one DNA molecule. In replication, the DNA molecule is copied, and the two molecules are known as chromatids. During the later stages of cell division these chromatids separate longitudinally to become individual chromosomes. Chromatid pairs are normally genetically identical, and said to be homozygous. However, if mutations occur, they will present slight differences, in which case they are heterozygous. The pairing of chromatids should not be confused with the ploidy of an organism, which is the number of homologous versions of a chromosome. Sister chromatids Chromatids may be sister or non-sister chromatids. A sister chromatid is either one of the two chromatids of the same chromosome joined together by a common centromere. A pair of sister chromatids is called a dyad. Once sister chromatids have separated (during the anaphase of m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cohesin
Cohesin is a protein complex that mediates sister chromatid cohesion, homologous recombination, and DNA looping. Cohesin is formed of SMC3, SMC1, SCC1 and SCC3 ( SA1 or SA2 in humans). Cohesin holds sister chromatids together after DNA replication until anaphase when removal of cohesin leads to separation of sister chromatids. The complex forms a ring-like structure and it is believed that sister chromatids are held together by entrapment inside the cohesin ring. Cohesin is a member of the SMC family of protein complexes which includes Condensin, MukBEF and SMC-ScpAB. Cohesin was separately discovered in budding yeast by Douglas Koshland and Kim Nasmyth. Structure Cohesin is a multi-subunit protein complex, made up of SMC1, SMC3, RAD21 and SCC3 (SA1 or SA2). SMC1 and SMC3 are members of the Structural Maintenance of Chromosomes (SMC) family. SMC proteins have two main structural characteristics: an ATP-binding cassette-like 'head' domain with ATPase activity (form ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Woods Hole
Woods Hole is a census-designated place in the town of Falmouth in Barnstable County, Massachusetts, United States. It lies at the extreme southwest corner of Cape Cod, near Martha's Vineyard and the Elizabeth Islands. The population was 781 at the 2010 census. It is the site of several marine science institutions, including Woods Hole Oceanographic Institution, the Marine Biological Laboratory, the Woodwell Climate Research Center, NOAA's Northeast Fisheries Science Center (which started the Woods Hole scientific community in 1871), the Woods Hole Science Aquarium, a USGS coastal and marine geology center, and the home campus of the Sea Education Association. And the headquarter of the Climate Foundation. It is also the site of United States Coast Guard Sector Southeastern New England (formerly USCG Group Woods Hole), the Nobska Light lighthouse, and the terminus of the Steamship Authority ferry route between Cape Cod and the island of Martha's Vineyard. History Histor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marine Biological Laboratory
The Marine Biological Laboratory (MBL) is an international center for research and education in biological and environmental science. Founded in Woods Hole, Massachusetts, in 1888, the MBL is a private, nonprofit institution that was independent for most of its history, but became officially affiliated with the University of Chicago on July 1, 2013. It also collaborates with numerous other institutions. As of 2022, 60 Nobel Prize winners have been affiliated with MBL as students, faculty members or researchers. In addition since 1960, there have been, 137 Howard Hughes Medical Institute investigators, early career scientists, international researchers, and professors; 306 members of the National Academy of Sciences; and 236 Members of the American Academy of Arts and Sciences who have been affiliated with the lab. History 19th century The Marine Biological Laboratory grew from the vision of several Bostonians and Spencer Fullerton Baird, the United States' first Fish Commiss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Boat Race
The Boat Race is an annual set of rowing races between the Cambridge University Boat Club and the Oxford University Boat Club, traditionally rowed between open-weight eights on the River Thames in London, England. There are separate men's and women's races, as well as races for reserve crews. It is also known as the University Boat Race and the Oxford and Cambridge Boat Race. The men's race was first held in 1829 and has been held annually since 1856, except during the First and Second World Wars (although unofficial races were conducted) and the COVID-19 pandemic in 2020. The first women's event was in 1927 and the race has been held annually since 1964. Since 2015, the women's race has taken place on the same day and course, and since 2018 the combined event of the two races has been referred to as the Boat Race. The Championship Course has hosted the vast majority of the races. It covers a stretch of the Thames in West London, from Putney to Mortlake. Other locati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barry Dickson
Barry J. Dickson (born 14 August 1962) is an Australian neurobiologist who studies the development of neuronal networks in the fruit fly Drosophila melanogaster. Dickson is a group leader at the Janelia Research Campus of the Howard Hughes Medical Institute in Loudoun County, Virginia and a former scientific director of the Research Institute of Molecular Pathology (IMP) in Vienna, Austria. Early life and education Barry Dickson was born in Melbourne, and studied mathematics, computer science and genetics at the University of Melbourne. He received his first bachelor of science degree in 1984. Until 1986, Dickson worked as a research assistant at the epidemiology unit at the University of Melbourne and at the Menzies School of Health Research in Darwin. He received a second bachelor of science with honors in 1987 for his thesis about “Interactions between multiple operator sites controlling transcription of the aroFtyrA operon of Escherichia coli K-12”. Dickson gained furt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Biology
Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and functioning of organisms. Cell biology is the study of structural and functional units of cells. Cell biology encompasses both prokaryotic and eukaryotic cells and has many subtopics which may include the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition. The study of cells is performed using several microscopy techniques, cell culture, and cell fractionation. These have allowed for and are currently being used for discoveries and research pertaining to how cells function, ultimately giving insight into understanding larger organisms. Knowing the components of cells and how cells work is fundamental to all biological sciences while also being essential for research in biomedical fields such as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
