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Amnon Albeck
Amnon Albeck (; born August 1, 1958) is an organic and bioorganic chemist. Biography Amnon Albeck was born in Jerusalem, Israel, to Michael and Shulamit Albeck on August 1, 1958. Amnon's father is the chemist Prof. Michael Albeck, the fifth president of Bar Ilan University (1986-1989) and former president of The Israel Chemical Society (1977-1980). His grandfather, Hanoch Albeck was a professor of Talmud at the Hebrew University of Jerusalem who was one of the founders of the scientific approach to the study of the Mishna. Albeck graduated from Bar Ilan University (Ramat Gan, Israel) with a BSc in chemistry in 1982, and earned his PhD from The Weizmann Institute of Science (Rehovot, Israel), under the supervision of Mordechai (Mudi) Sheves, in 1988. He then spent two years as a post-doctoral Fellow with Robert H. Abeles at Brandeis University in Massachusetts, USA. In 1990 he returned to Bar Ilan University as a faculty member at the Department of Chemistry, where Albeck ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during a Chemical reaction, reaction with other Chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the properties ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hebrew University Of Jerusalem
The Hebrew University of Jerusalem (HUJI; he, הַאוּנִיבֶרְסִיטָה הַעִבְרִית בִּירוּשָׁלַיִם) is a public research university based in Jerusalem, Israel. Co-founded by Albert Einstein and Dr. Chaim Weizmann in July 1918, the public university officially opened in April 1925. It is the second-oldest Israeli university, having been founded 30 years before the establishment of the State of Israel but six years after the older Technion university. The HUJI has three campuses in Jerusalem and one in Rehovot. The world's largest library for Jewish studies—the National Library of Israel—is located on its Edmond J. Safra campus in the Givat Ram neighbourhood of Jerusalem. The university has five affiliated teaching hospitals (including the Hadassah Medical Center), seven faculties, more than 100 research centers, and 315 academic departments. , one-third of all the doctoral candidates in Israel were studying at the HUJI. Among its first ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tellurium Trioxide
Tellurium trioxide ( Te O3) is an inorganic chemical compound of tellurium and oxygen. In this compound, tellurium is in the +6 oxidation state In chemistry, the oxidation state, or oxidation number, is the hypothetical charge of an atom if all of its bonds to different atoms were fully ionic. It describes the degree of oxidation (loss of electrons) of an atom in a chemical compound. C .... Polymorphs There are two forms, yellow-red α-TeO3 and grey, rhombohedral, β-TeO3 which is less reactive.''Inorganic Chemistry'',Egon Wiberg, Arnold Frederick Holleman Elsevier 2001 α-TeO3 has a structure similar to FeF3 with octahedral TeO6 units that share all vertices. Preparation α-TeO3 can be prepared by heating orthotelluric acid, Te(OH)6, at over 300 °C. The β-TeO3 form can be prepared by heating α-TeO3 in a sealed tube with O2 and H2SO4. α-TeO3 is unreactive to water but is a powerful oxidising agent when heated. With alkalis it forms tellurates. α-TeO3 when heat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme Catalysis
Enzyme catalysis is the increase in the rate of a process by a biological molecule, an "enzyme". Most enzymes are proteins, and most such processes are chemical reactions. Within the enzyme, generally catalysis occurs at a localized site, called the active site. Most enzymes are made predominantly of proteins, either a single protein chain or many such chains in a multi-subunit complex. Enzymes often also incorporate non-protein components, such as metal ions or specialized organic molecules known as cofactor (e.g. adenosine triphosphate). Many cofactors are vitamins, and their role as vitamins is directly linked to their use in the catalysis of biological process within metabolism. Catalysis of biochemical reactions in the cell is vital since many but not all metabolically essential reactions have very low rates when uncatalysed. One driver of protein evolution is the optimization of such catalytic activities, although only the most crucial enzymes operate near catalytic e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Modelling
Molecular modelling encompasses all methods, theoretical and computational, used to model or mimic the behaviour of molecules. The methods are used in the fields of computational chemistry, drug design, computational biology and materials science to study molecular systems ranging from small chemical systems to large biological molecules and material assemblies. The simplest calculations can be performed by hand, but inevitably computers are required to perform molecular modelling of any reasonably sized system. The common feature of molecular modelling methods is the atomistic level description of the molecular systems. This may include treating atoms as the smallest individual unit (a molecular mechanics approach), or explicitly modelling protons and neutrons with its quarks, anti-quarks and gluons and electrons with its photons (a quantum chemistry approach). Molecular mechanics Molecular mechanics is one aspect of molecular modelling, as it involves the use of classical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Delivery
Drug delivery refers to approaches, formulations, manufacturing techniques, storage systems, and technologies involved in transporting a pharmaceutical compound to its target site to achieve a desired therapeutic effect. Principles related to drug preparation, route of administration, site-specific targeting, metabolism, and toxicity are used to optimize efficacy and safety, and to improve patient convenience and compliance. Drug delivery is aimed at altering a drug's pharmacokinetics and specificity by formulating it with different excipients, drug carriers, and medical devices. There is additional emphasis on increasing the bioavailability and duration of action of a drug to improve therapeutic outcomes. Some research has also been focused on improving safety for the person administering the medication. For example, several types of microneedle patches have been developed for administering vaccines and other medications to reduce the risk of needlestick injury. Drug deliv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug. The entire process – from concept through preclinical testing in the laboratory to clinical trial development, including Phase I–III trials – to approved vaccine or drug typically takes more than a decade. New chemical entity development Broadly, the process of drug development can be divided into preclinical and clinical work. Pre-clinical New chemical entities (NCEs, also known as new molecular entities or NMEs) are compounds that emerge from the process of drug discovery. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protease
A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes (increases reaction rate or "speeds up") proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. They do this by cleaving the peptide bonds within proteins by hydrolysis, a reaction where water breaks bonds. Proteases are involved in many biological functions, including digestion of ingested proteins, protein catabolism (breakdown of old proteins), and cell signaling. In the absence of functional accelerants, proteolysis would be very slow, taking hundreds of years. Proteases can be found in all forms of life and viruses. They have independently evolved multiple times, and different classes of protease can perform the same reaction by completely different catalytic mechanisms. Hierarchy of proteases Based on catalytic residue Proteases can be classified into seven broad groups: * Serine protease ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme Inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity. Enzymes are proteins that speed up chemical reactions necessary for life, in which substrate molecules are converted into products. An enzyme facilitates a specific chemical reaction by binding the substrate to its active site, a specialized area on the enzyme that accelerates the most difficult step of the reaction. An enzyme inhibitor stops ("inhibits") this process, either by binding to the enzyme's active site (thus preventing the substrate itself from binding) or by binding to another site on the enzyme such that the enzyme's catalysis of the reaction is blocked. Enzyme inhibitors may bind reversibly or irreversibly. Irreversible inhibitors form a chemical bond with the enzyme such that the enzyme is inhibited until the chemical bond is broken. By contrast, reversible inhibitors bind non-covalently and may spontaneously leave the enzyme, allowing the enzyme to resume its function. Reve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Miriam Faust
Miriam ( he, מִרְיָם ''Mīryām'', lit. 'Rebellion') is described in the Hebrew Bible as the daughter of Amram and Jochebed, and the older sister of Moses and Aaron. She was a prophetess and first appears in the Book of Exodus. The Torah refers to her as "Miriam the Prophetess" and the Talmud names her as one of the seven major female prophets of Israel. Scripture describes her alongside of Moses and Aaron as delivering the Jews from exile in Egypt: "For I brought you up out of the land of Egypt and redeemed you from the house of slavery, and I sent before you Moses, Aaron, and Miriam". According to the Midrash, just as Moses led the men out of Egypt and taught them Torah, so too Miriam led the women and taught them Torah. Biblical narrative Miriam was the daughter of Amram and Jochebed; she was the sister of Aaron and Moses, the leader of the Israelites in ancient Egypt. The narrative of Moses' infancy in the Torah describes an unnamed sister of Moses observing him b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rector (academia)
A rector (Latin for 'ruler') is a senior official in an educational institution, and can refer to an official in either a university or a secondary school. Outside the English-speaking world the rector is often the most senior official in a university, whilst in the United States the most senior official is often referred to as president and in the United Kingdom and Commonwealth of Nations the most senior official is the chancellor, whose office is primarily ceremonial and titular. The term and office of a rector can be referred to as a rectorate. The title is used widely in universities in EuropeEuropean nations where the word ''rector'' or a cognate thereof (''rektor'', ''recteur'', etc.) is used in referring to university administrators include Albania, Austria, the Benelux, Bosnia and Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, Germany, Greece, Hungary, Iceland, Italy, Latvia, Malta, Moldova, North Macedonia, Poland, Portugal, Romani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Julius Spokojny
The gens Julia (''gēns Iūlia'', ) was one of the most prominent patrician families in ancient Rome. Members of the gens attained the highest dignities of the state in the earliest times of the Republic. The first of the family to obtain the consulship was Gaius Julius Iulus in 489 BC. The gens is perhaps best known, however, for Gaius Julius Caesar, the dictator and grand uncle of the emperor Augustus, through whom the name was passed to the so-called Julio-Claudian dynasty of the first century AD. The Julius became very common in imperial times, as the descendants of persons enrolled as citizens under the early emperors began to make their mark in history.''Dictionary of Greek and Roman Biography and Mythology'', vol. II, pp. 642, 643. Origin The Julii were of Alban origin, mentioned as one of the leading Alban houses, which Tullus Hostilius removed to Rome upon the destruction of Alba Longa. The Julii also existed at an early period at Bovillae, evidenced by a very a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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