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Alzheimer's Drug Discovery Foundation
The Alzheimer's Drug Discovery Foundation (ADDF) is a nonprofit organization founded in 1998 by co-chairmen Leonard A. Lauder and Ronald S. Lauder of the Estée Lauder Companies cosmetics family and led by Howard Fillit, a geriatrician and neuroscientist. The ADDF provides funding to scientists who are conducting promising, innovative Alzheimer's disease drug research worldwide. The ADDF funds early-stage research and early-phase clinical trials that might otherwise go unfunded. By supporting research projects around the world, it seeks to increase the chances of finding treatments for Alzheimer's disease, related dementias and cognitive aging. The ADDF has invested nearly $65 million to fund some 450 Alzheimer's drug discovery programs and clinical trials in academic centers and biotechnology companies in 18 countries. The ADDF also publishes peer-reviewed scientific articles with the goal of accelerating and improving Alzheimer's disease drug discovery research. Funding model ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nonprofit Organization
A nonprofit organization (NPO) or non-profit organisation, also known as a non-business entity, not-for-profit organization, or nonprofit institution, is a legal entity organized and operated for a collective, public or social benefit, in contrast with an entity that operates as a business aiming to generate a Profit (accounting), profit for its owners. A nonprofit is subject to the non-distribution constraint: any revenues that exceed expenses must be committed to the organization's purpose, not taken by private parties. An array of organizations are nonprofit, including some political organizations, schools, business associations, churches, social clubs, and consumer cooperatives. Nonprofit entities may seek approval from governments to be Tax exemption, tax-exempt, and some may also qualify to receive tax-deductible contributions, but an entity may incorporate as a nonprofit entity without securing tax-exempt status. Key aspects of nonprofits are accountability, trustworth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Preclinical
In drug development, preclinical development, also termed preclinical studies or nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals. The main goals of preclinical studies are to determine a starting, safe dose for first-in-human study and assess potential toxicity of the product, which typically include new medical devices, prescription drugs, and diagnostics. Companies use stylized statistics to illustrate the risks in preclinical research, such as that on average, only one in every 5,000 compounds that enters drug discovery to the stage of preclinical development becomes an approved drug. Types of preclinical research Each class of product may undergo different types of preclinical research. For instance, drugs may undergo pharmacodynamics (what the drug does to the body) (PD), pharmacokinetics (wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical And Health Foundations In The United States
Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of skill and knowledge), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, or an ancien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carolina Herrera (fashion Designer)
Carolina Herrera (born María Carolina Josefina Pacanins y Niño; 8 January 1939) is a Venezuelan-American fashion designer known for her personal style, and for dressing various First Ladies, including Jacqueline Onassis, Laura Bush, Michelle Obama, and Melania Trump. Early life María Carolina Josefina Pacanins y Niño was born on 8 January 1939, in Caracas, Venezuela, to Guillermo Pacanins Acevedo, an air force officer and former governor of Caracas, and María Cristina Niño Passios. Her socialite grandmother introduced her to the world of fashion, taking young Carolina to shows by Balenciaga and buying her outfits at Lanvin and Dior. She has said, "My eye was accustomed to seeing pretty things." Career and brand In 1965, Herrera began her career working as a publicist for Emilio Pucci, a Florentine Marquis himself and a close family friend. She began working at Pucci's Caracas boutique, and moved to New York in 1980. Frequently associating with Mick and Bian ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jason Wu
Jason Wu (; born September 27, 1982) is a Taiwanese-Canadian artist and fashion designer based in New York City. Born in Taiwan and raised in Vancouver, he studied fashion design at Parsons School of Design, and trained under Narciso Rodriguez before launching his own line. He is best known for designing the dresses of Michelle Obama on several occasions, including those worn during the first and second inauguration of American President Barack Obama. Early life Jason Wu was born in Yunlin, Taiwan and emigrated to Vancouver, British Columbia, Canada at age nine. He attended Eaglebrook School in Deerfield, Massachusetts and Loomis Chaffee in Windsor, Connecticut and studied abroad witSYA France of School Year Abroadfor his senior year of high school. He learned how to sew by designing and sewing for dolls, and went on to study sculpture in Tokyo. At age sixteen Wu continued this career path by learning to create freelance doll clothing designs for toy company Integrity T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erdem Moralıoğlu
Erdem Moralıoğlu (born November 1977) is a British fashion designer. Early life and education Moralıoğlu was born in Montreal, Quebec, Canada to a Turkish people, Turkish father and an English mother (nee Jeavons), and grew up between Montreal and Birmingham, England. A graduate of Marianopolis College, Moralıoğlu earned a BA in fashion from Ryerson Polytechnical Institute in Toronto, Canada and then worked as an intern for Vivienne Westwood. He moved to London in 2000 to study fashion at the Royal College of Art on a Chevening Scholarship. Career Moralıoğlu moved to New York before relocating back to London to launch his own label, ERDEM, in 2005. In 2017, ERDEM collaborated with H&M, Moralıoğlu’s first collection for men; director Baz Luhrmann created the visuals for the campaign. In 2018, Moralıoğlu designed costumes for 24 ballet dancers performing in Christopher Wheeldon's ''Corybantic Games'' at the Royal Opera House in London. In 2021, ERDEM expanded to d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Contract Research Organizations
In the life sciences, a contract research organization (CRO) is a company that provides support to the pharmaceutical, biotechnology, and medical device industries in the form of research services outsourced on a contract basis. A CRO may provide such services as biopharmaceutical development, biological assay development, commercialization, clinical development, clinical trials management, pharmacovigilance, outcomes research, and Real world evidence. CROs are designed to reduce costs for companies developing new medicines and drugs in niche markets. They aim to simplify entry into drug markets, and simplify development, as the need for large pharmaceutical companies to do everything ‘in house’ is now redundant. CROs also support foundations, research institutions, and universities, in addition to governmental organizations (such as the NIH, EMA, etc.). Many CROs specifically provide clinical-study and clinical-trial support for drugs and/or medical devices. However, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomarker
In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. as cited in Biomarkers are used in many scientific fields. Medicine Biomarkers used in the medical field, are a part of a relatively new clinical toolset categorized by their clinical applications. The three main classes are molecular biomarkers, cellular biomarkers or imaging biomarkers. All three types of biomarkers have a clinical role in narrowing or guiding treatment decisions and follow a sub-categorization of being either predictive, prognostic, or diagnostic. Predictive Predictive molecular, cellular, or imaging biomarkers that pass validation can serve as a method of predicting clinical outcomes. Predictive biomarkers are used to help optimize id ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proof-of-concept
Proof of concept (POC or PoC), also known as proof of principle, is a realization of a certain method or idea in order to demonstrate its feasibility, or a demonstration in principle with the aim of verifying that some concept or theory has practical potential. A proof of concept is usually small and may or may not be complete. These collaborative trials aim to test feasibility of business concepts and proposals to solve business problems and accelerate business innovation goals. A proof of value (PoV) is sometimes used along proof of concept, and differs by focusing more on demonstrating the potential customers use case and value, and is usually less in-depth than a proof of concept. Usage history The term has been in use since 1967. In a 1969 hearing of the Committee on Science and Astronautics, Subcommittee on Advanced Research and Technology, ''proof of concept'' was defined as following: One definition of the term "proof of concept" was by Bruce Carsten in the context o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ApoE
Apolipoprotein E (APOE) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular disease. APOE belongs to a family of fat-binding proteins called apolipoproteins. In the circulation, it is present as part of several classes of lipoprotein particles, including chylomicron remnants, VLDL, IDL, and some HDL. APOE interacts significantly with the low-density lipoprotein receptor (LDLR), which is essential for the normal processing ( catabolism) of triglyceride-rich lipoproteins. In peripheral tissues, APOE is primarily produced by the liver and macrophages, and mediates cholesterol metabolism. In the central nervous system, APOE is mainly produced by astrocytes and transports cholesterol to neurons via APOE receptors, which are members of the low density lipoprotein receptor gene family. APOE is the principal cholesterol carrier in the brain. APOE is required for cholesterol transportation from ast ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroprotection
Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal loss over time, which can be expressed as a differential equation. It is a widely explored treatment option for many central nervous system (CNS) disorders including neurodegenerative diseases, stroke, traumatic brain injury, spinal cord injury, and acute management of neurotoxin consumption (i.e. methamphetamine overdoses). Neuroprotection aims to prevent or slow disease progression and secondary injuries by halting or at least slowing the loss of neurons. Despite differences in symptoms or injuries associated with CNS disorders, many of the mechanisms behind neurodegeneration are the same. Common mechanisms of neuronal injury include decreased delivery of oxygen and glucose to the brain, energy failure, increased levels in oxidative ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Florbetapir (18F)
Florbetapir (18F), sold under the brand name Amyvid, is a PET scanning radiopharmaceutical compound containing the radionuclide fluorine-18 that was approved for use in the United States in 2012, as a diagnostic tool for Alzheimer's disease. * Florbetapir, like Pittsburgh compound B (PiB), binds to beta-amyloid, however fluorine-18 has a half-life of 109.75 minutes, in contrast to PiB's radioactive half life of 20 minutes. Wong ''et al.'' found that the longer life allowed the tracer to accumulate significantly more in the brains of people with AD, particularly in the regions known to be associated with beta-amyloid deposits. One review predicted that amyloid imaging is likely to be used in conjunction with other markers rather than as an alternative. Development Since the disease was first described by Alois Alzheimer in 1906, the only certain way to determine if a person indeed had the disease was to perform a biopsy on the patient's brain to find distinctive spots on the b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
