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Alzheimer's Disease Cooperative Study
The Alzheimer's Disease Cooperative Study (ADCS) was founded at University of California San Diego in 1991 and coordinates clinical trials of candidate treatments for Alzheimer's disease. It is funded by the National Institutes of Health as well as companies that develop drugs. As of 2008, 75 research sites in the United States and Canada were part of the consortium. Leon Thal served as director until February 2007, when he died; Paul Aisen was recruited to succeed him. In 2006, the NIH awarded $52 million to ADCS to fund 6 years of further clinical trials. In 2013 Eli Lilly committed to spending $76.6 million on clinical trials through the center. The center has coordinated important clinical trials on AD drugs like solanezumab Solanezumab (proposed INN, LY2062430) is a monoclonal antibody being investigated by Eli Lilly as a neuroprotector for patients with Alzheimer's disease. The drug originally attracted extensive media coverage proclaiming it a breakthrough, but . ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California San Diego
The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is the southernmost of the ten campuses of the University of California, and offers over 200 undergraduate and graduate degree programs, enrolling 33,096 undergraduate and 9,872 graduate students. The university occupies near the coast of the Pacific Ocean, with the main campus resting on approximately . UC San Diego is ranked among the best universities in the world by major college and university rankings. UC San Diego consists of twelve undergraduate, graduate and professional schools as well as seven undergraduate residential colleges. It received over 140,000 applications for undergraduate admissions in Fall 2021, making it the second most applied-to university in the United States. UC San Diego Health, the region's only academic health ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term memory, remembering recent events. As the disease advances, symptoms can include primary progressive aphasia, problems with language, Orientation (mental), disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and challenging behaviour, behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research instit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leon Thal
Leon, Léon (French) or León (Spanish) may refer to: Places Europe * León, Spain, capital city of the Province of León * Province of León, Spain * Kingdom of León, an independent state in the Iberian Peninsula from 910 to 1230 and again from 1296 to 1301 * León (historical region), composed of the Spanish provinces León, Salamanca, and Zamora * Viscounty of Léon, a feudal state in France during the 11th to 13th centuries * Saint-Pol-de-Léon, a commune in Brittany, France * Léon, Landes, a commune in Aquitaine, France * Isla de León, a Spanish island * Leon (Souda Bay), an islet in Souda Bay, Chania, on the island of Crete North America * León, Guanajuato, Mexico, a large city * Leon, California, United States, a ghost town * Leon, Iowa, United States * Leon, Kansas, United States * Leon, New York, United States * Leon, Oklahoma, United States * Leon, Virginia, United States * Leon, West Virginia, United States * Leon, Wisconsin (other), United States, sever ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Aisen
Paul Stephen Aisen is an American physician and medical researcher. He started his career as a rheumatologist and then made Alzheimer's disease his focus. As of 2015 he was on the faculty of the Keck School of Medicine of USC and his offices were in San Diego. Aisen did his undergraduate work in biochemistry and molecular biology at Harvard and obtained his medical degree from Columbia University. He did his residency at Case Western Reserve University and at Mount Sinai Medical Center in New York, and trained further through a fellowship in rheumatology at New York University. He has a private practice as a GP and rheumatologist in New York, then joined the faculty of Mount Sinai in 1994. He was recruited to the Georgetown University School of Medicine in 1999 in neurology and medicine and began focusing his practice and research on Alzheimer's disease there. In 2007 Aisen was recruited to University of California San Diego to run the Alzheimer's Disease Cooperative Study, whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eli Lilly And Company
Eli Lilly and Company is an American pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was founded in 1876 by, and named after, Colonel Eli Lilly, a pharmaceutical chemist and veteran of the American Civil War. As of 2022, Lilly is known for its clinical depression drugs Prozac ( fluoxetine) (1986) and Cymbalta (duloxetine) (2004) and its antipsychotic medication Zyprexa (olanzapine) (1996), although its primary revenue drivers are the diabetes drugs Humalog (insulin lispro) (1996) and Trulicity (dulaglutide) (2014). Lilly's achievements include being the first company to mass-produce the polio vaccine developed by Jonas Salk, and insulin. It was one of the first pharmaceutical companies to produce human insulin using recombinant DNA including Humulin ( insulin medication), Humalog (insulin lispro), and the first approved biosimilar insulin product in the US, Basaglar ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solanezumab
Solanezumab (proposed INN, LY2062430) is a monoclonal antibody being investigated by Eli Lilly as a neuroprotector for patients with Alzheimer's disease. The drug originally attracted extensive media coverage proclaiming it a breakthrough, but it has failed to show promise in Phase III trials. Medical uses Solanezumab was safely used in combination with approved Alzheimer's disease treatment, such as acetylcholinesterase inhibitors or memantine, in the clinical trials. Aside from Alzheimer's disease, there are other amyloid beta related diseases, in which solanezumab could be used, e.g., Down syndrome or cerebral amyloid angiopathy. However, this has not been studied so far. Adverse effects No safety concerns were detected in any of the studies. A few patients suffered from mild infusion reactions that resolved on their own. The measured laboratory values and vital signs, showed no changes. Other adverse events that occurred, e.g., headache or hematoma, were not consider ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amazon Web Services
Amazon Web Services, Inc. (AWS) is a subsidiary of Amazon.com, Amazon that provides Software as a service, on-demand cloud computing computing platform, platforms and Application programming interface, APIs to individuals, companies, and governments, on a metered pay-as-you-go basis. These cloud computing web services provide distributed computing processing capacity and software tools via AWS server farms. One of these services is Amazon Elastic Compute Cloud (EC2), which allows users to have at their disposal a Virtualization, virtual Computer cluster, cluster of computers, available all the time, through the Internet. AWS's virtual computers emulate most of the attributes of a real computer, including hardware central processing units (CPUs) and graphics processing units (GPUs) for processing; local/Random-access memory, RAM memory; hard-disk/Solid-state drive, SSD storage; a choice of operating systems; networking; and pre-loaded application software such as web servers, dat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
