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Alexander Rich
Alexander Rich (15 November 1924 – 27 April 2015) was an American biologist and biophysicist. He was the William Thompson Sedgwick Professor of Biophysics at MIT (since 1958) and Harvard Medical School. Rich earned an A.B. (''magna cum laude'') and an M.D. (''cum laude'') from Harvard University. He was a post-doc of Linus Pauling along with James Watson. During this time he was a member of the RNA Tie Club, a social and discussion group which attacked the question of how DNA encodes proteins. He had over 600 publications to his name. Born in Hartford, Connecticut, Rich was the founder of Alkermes and was a director beginning in 1987. Dr. Rich was co-chairman of the board of directors of Repligen Corporation, a biopharmaceutical company. He also served on the editorial board of ''Genomics'' and the ''Journal of Biomolecular Structure and Dynamics''. Personal life Rich spent his early life in Springfield, Massachusetts. He grew up in a working-class family and worke ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hartford, Connecticut
Hartford is the capital city of the U.S. state of Connecticut. It was the seat of Hartford County until Connecticut disbanded county government in 1960. It is the core city in the Greater Hartford metropolitan area. Census estimates since the 2010 United States census have indicated that Hartford is the fourth-largest city in Connecticut with a 2020 population of 121,054, behind the coastal cities of Bridgeport, New Haven, and Stamford. Hartford was founded in 1635 and is among the oldest cities in the United States. It is home to the country's oldest public art museum ( Wadsworth Atheneum), the oldest publicly funded park (Bushnell Park), the oldest continuously published newspaper (the '' Hartford Courant''), and the second-oldest secondary school ( Hartford Public High School). It is also home to the Mark Twain House, where the author wrote his most famous works and raised his family, among other historically significant sites. Mark Twain wrote in 1868, "Of all the be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linus Pauling
Linus Carl Pauling (; February 28, 1901August 19, 1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. ''New Scientist'' called him one of the 20 greatest scientists of all time, and as of 2000, he was rated the 16th most important scientist in history. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of five people to have won more than one Nobel Prize (the others being Marie Curie, John Bardeen, Frederick Sanger and Karl Barry Sharpless). Of these, he is the only person to have been awarded two unshared Nobel Prizes, and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie. Pauling was one of the founders of the fields of quantum chemistry and molecular biology. His contributions to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polysome
A polyribosome (or polysome or ergosome) is a group of ribosomes bound to an mRNA molecule like “beads” on a “thread”. It consists of a complex of an mRNA molecule and two or more ribosomes that act to translate mRNA instructions into polypeptide Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. ...s. Originally coined "ergosomes" in 1963, they were further characterized by Jonathan Warner, Paul M. Knopf, and Alex Rich. Polysomes are formed during the elongation phase when ribosomes and elongation factors synthesize the encoded polypeptide. Multiple ribosomes move along the coding region of mRNA, creating a polysome. The ability of multiple ribosomes to function on an mRNA molecule explains the limited abundance of mRNA in the cell. Polyribosome structure differs between pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Collagen
Collagen () is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. Collagen consists of amino acids bound together to form a triple helix of elongated fibril known as a collagen helix. It is mostly found in connective tissue such as cartilage, bones, tendons, ligaments, and skin. Depending upon the degree of mineralization, collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of the skeletal muscle tissue. The fibroblast is the most common ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cavendish Laboratory
The Cavendish Laboratory is the Department of Physics at the University of Cambridge, and is part of the School of Physical Sciences. The laboratory was opened in 1874 on the New Museums Site as a laboratory for experimental physics and is named after the British chemist and physicist Henry Cavendish. The laboratory has had a huge influence on research in the disciplines of physics and biology. The laboratory moved to its present site in West Cambridge in 1974. , 30 Cavendish researchers have won Nobel Prizes. Notable discoveries to have occurred at the Cavendish Laboratory include the discovery of the electron, neutron, and structure of DNA. Founding The Cavendish Laboratory was initially located on the New Museums Site, Free School Lane, in the centre of Cambridge. It is named after British chemist and physicist Henry Cavendish for contributions to science and his relative William Cavendish, 7th Duke of Devonshire, who served as chancellor of the university and donated f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical researc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Watson
James Dewey Watson (born April 6, 1928) is an American molecular biologist, geneticist, and zoologist. In 1953, he co-authored with Francis Crick the academic paper proposing the double helix structure of the DNA molecule. Watson, Crick and Maurice Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material". In subsequent years, it has been recognized that Watson and his colleagues did not properly attribute colleague Rosalind Franklin for her contributions to the discovery of the double helix structure. Watson earned degrees at the University of Chicago ( BS, 1947) and Indiana University (PhD, 1950). Following a post-doctoral year at the University of Copenhagen with Herman Kalckar and Ole Maaløe, Watson worked at the University of Cambridge's Cavendish Laboratory in England, where he first met his future collaborator ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California Institute Of Technology
The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasionally referred to as "CIT", most notably in its alma mater, but this is uncommon. is a private university, private research university in Pasadena, California. Caltech is ranked among the best and most selective academic institutions in the world, and with an enrollment of approximately 2400 students (acceptance rate of only 5.7%), it is one of the world's most selective universities. The university is known for its strength in science and engineering, and is among a small group of Institute of Technology (United States), institutes of technology in the United States which is primarily devoted to the instruction of pure and applied sciences. The institution was founded as a preparatory and vocational school by Amos G. Throop in 1891 and began ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Tileston Edsall
John Tileston Edsall (3 November 1902 – 12 June 2002) was a protein scientist, who contributed significantly to the understanding of the hydrophobic interaction. Early life Born in Philadelphia, John Edsall moved to Boston with his family at the age of 10. He graduated from Harvard University with a degree in chemistry. At Harvard he was a good friend of the physicist Robert Oppenheimer. He wrote an account of his life and career in a review. Protein research Edsall worked with Edwin Cohn during World War II to apply protein methods to blood fractionation. Subsequently, in 1943, they published a book ''Proteins, Amino Acids and Peptides''. This had a profound influence on the next generation of protein scientists. Long afterwards Edsall wrote an account of his interaction with Cohn. He published numerous papers on protein chemistry, including work on myosin, fibrinogen, light scattering, measurement of tyrosine groups by ultraviolet spectroscopy, and carbonic anhydrase. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Navy
The United States Navy (USN) is the maritime service branch of the United States Armed Forces and one of the eight uniformed services of the United States. It is the largest and most powerful navy in the world, with the estimated tonnage of its active battle fleet alone exceeding the next 13 navies combined, including 11 allies or partner nations of the United States as of 2015. It has the highest combined battle fleet tonnage (4,635,628 tonnes as of 2019) and the world's largest aircraft carrier fleet, with eleven in service, two new carriers under construction, and five other carriers planned. With 336,978 personnel on active duty and 101,583 in the Ready Reserve, the United States Navy is the third largest of the United States military service branches in terms of personnel. It has 290 deployable combat vessels and more than 2,623 operational aircraft . The United States Navy traces its origins to the Continental Navy, which was established during the American R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genomics (journal)
''Genomics'' is a peer-reviewed scientific journal in genomics, publishing articles on topics such as comparative genomics, functional genomics, association studies, regulatory DNA elements, and genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working i ... on a genome-wide scale. The journal was established in September 1987. Entrez NLM Catalog. Accessed 18 Aug 2009. Abstracting and indexing The journal is abstracted and indexed in:References External links * Genetics journals[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Repligen
Repligen is an American company devoted to the development and production of materials used in the manufacture of biological drugs. The company is based in Waltham, Massachusetts, and incorporated in Delaware in 1981. A public company, Repligen is listed on the NASDAQ exchange under the symbol RGEN. , Repligen employed 116 people, about 50% of these based in Sweden. Business model Before 2012, Repligen maintained dual capabilities in developing pharmaceutical therapeutics (drug discovery and development) and the development of materials supporting biological drug manufacture (bioprocessing business). A decision was made in 2012 to focus on the bioprocessing business and reduce research and development expenditures. In the period of 2010 to 2013, the majority of sales by the company were concentrated in the single Protein A product line. Sales and revenue Repligen employs a direct sales model to users of its products in the United States, with some sales through inter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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