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Alexander J. Varshavsky
Alexander Jacob Varshavsky (russian: link=no, Александр Яковлевич Варшавский; born 8 November 1946) is a Russian-American biochemist, noted for his discovery of the N-end rule of ubiquitination. A native of Moscow, he is currently researching at Caltech. Varshavsky provided an original approach to killing cancer cells, proffering the idea of a targeted molecular device that could enter a cell, examine it for DNA deletions specific to cancer and killing it if it meets the right profile. "(It) involves, in a nutshell, the finding of a genuine Achilles' heel of cancer cells, i.e. their potentially vulnerable feature that won't change during tumor progression," said Varshavsky. The approach termed deletion-specific targeting (DST), employs HDs (homozygous DNA deletions) as the targets of cancer therapy. "In contrast to other attributes of cancer cells, their HDs are immutable markers. If the DST strategy can be implemented in a clinical setting, it may pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-end Rule
The ''N''-end rule is a rule that governs the rate of protein degradation through recognition of the N-terminal residue of proteins. The rule states that the ''N''-terminal amino acid of a protein determines its half-life (time after which half of the total amount of a given polypeptide is degraded). The rule applies to both eukaryotic and prokaryotic organisms, but with different strength, rules, and outcome. In eukaryotic cells, these N-terminal residues are recognized and targeted by ubiquitin ligases, mediating ubiquitination thereby marking the protein for degradation. The rule was initially discovered by Alexander Varshavsky and co-workers in 1986. However, only rough estimations of protein half-life can be deduced from this 'rule', as N-terminal amino acid modification can lead to variability and anomalies, whilst amino acid impact can also change from organism to organism. Other degradation signals, known as degrons, can also be found in sequence. Rules in different organis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Vilcek Foundation
The Vilcek Foundation raises awareness of immigrant contributions to the United States, and fosters appreciation of the arts and sciences. The foundation's flagship programs include the Vilcek Foundation Prizes, which recognize and support immigrant contributions to American arts, biomedical science, and society. The foundation is also the designated steward of the art collection assembled by founders Jan and Marica Vilcek, comprising holdings in American modernism, Native American pottery, pre Columbian objects, and contemporary art. The Foundation was established in 2000 by Jan and Marica Vilcek, immigrants from the former Czechoslovakia. The mission of the Foundation was inspired by the couple's respective careers in biomedical science and art history, as well as their personal experiences and appreciation for the opportunities offered them as newcomers to the United States. Prizes Vilcek Prizes The Vilcek Prizes are awarded to foreign-born individuals residing permanently in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American People Of Russian Descent
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Biochemists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2022 Russian Invasion Of Ukraine
On 24 February 2022, in a major escalation of the Russo-Ukrainian War, which began in 2014. The invasion has resulted in tens of thousands of deaths on both sides. It has caused Europe's largest refugee crisis since World War II. An estimated 8 million Ukrainians were displaced within their country by late May and 7.8 million fled the country by 8 November 2022, while Russia, within five weeks of the invasion, experienced its greatest emigration since the 1917 October Revolution. Following the 2014 Ukrainian Revolution, Russia annexed Crimea, and Russian-backed paramilitaries seized part of the Donbas region of south-eastern Ukraine, which consists of Luhansk and Donetsk oblasts, sparking a regional war. In March 2021, Russia began a large military build-up along its border with Ukraine, eventually amassing up to 190,000 troops and their equipment. Despite the build-up, denials of plans to invade or attack Ukraine were issued by various Russian gove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heinrich Wieland Prize
The Heinrich Wieland Prize is awarded annually by the Boehringer Ingelheim Foundation for outstanding research on biologically active molecules and systems in the areas of chemistry, biochemistry and physiology as well as their clinical importance. In 1963, the Margarine Institute established the Heinrich Wieland Prize to support research in the field of lipids. In 2000, the Margarine Institute ended its sponsorship of the Prize and the pharmaceutical company Boehringer Ingelheim became the new sponsor. In 2011, the Boehringer Ingelheim Foundation took over the prize. The awardee is selected by a scientific board of trustees. The prize is named after the Nobel Prize Laureate in chemistry Professor Heinrich Wieland (1877-1957), one of the leading lipid chemists of the first half of the 20th century. To mark its 50th anniversary in 2014, the prize money was raised to 100,000 euros. Four of its awardees have gone on to receive the Nobel Prize: Michael S. Brown and Joseph L. Goldst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Otto Warburg Medal
The Otto Warburg Medal is awarded annually by the German Society for Biochemistry and Molecular Biology (German: ''Gesellschaft für Biochemie und Molekularbiologie'' or ''GBM'') to honour scientists who have contributed important work in the field of biological chemistry. It is named after Otto Warburg, a renowned German physiologist and Nobel Prize laureate. It was first awarded on his 80th birthday on 8 October 1963. Up to 2013, nine Warburg Medal recipients have also been awarded the Nobel Prize. Medallists SourceGBM See also * List of biochemistry awards * List of biology awards * List of awards named after people This is a list of awards that are named after people. A B C D E F G H I J K L M N O P R S T U - V W Y Z See also *Lists of awards *List of eponyms A ''list'' is any set of items in a row ... References {{reflist Biology awards German awards Awards established in 1963 Biochemistry awards ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
King Faisal International Prize
The King Faisal Prize ( ar, جائزة الملك فيصل, formerly King Faisal International Prize), is an annual award sponsored by King Faisal Foundation presented to "dedicated men and women whose contributions make a positive difference". The foundation awards prizes in five categories: Service to Islam; Islamic studies; the Arabic language and Arabic literature; science; and medicine. Three of the prizes are widely considered as the most prestigious awards in the Muslim world. The first King Faisal Prize was awarded to the Pakistani scholar Abul A'la Maududi in the year 1979 for his service to Islam. In 1981, Khalid of Saudi Arabia received the same award. In 1984, Fahd of Saudi Arabia was the recipient of the award. In 1986, this prize was co-awarded to Ahmed Deedat and French Roger Garaudy. Award process Designation of subjects Each year, the selection committees designate subjects in Islamic Studies, Arabic Literature, and Medicine. Selected topics in Islamic Studies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leopold Griffuel Prize Of The French Charity Fondation ARC
Leopold may refer to: People * Leopold (given name) * Leopold (surname) Arts, entertainment, and media Fictional characters * Leopold (''The Simpsons''), Superintendent Chalmers' assistant on ''The Simpsons'' * Leopold Bloom, the protagonist of James Joyce's ''Ulysses'' * Leopold "Leo" Fitz, a character on the television series ''Agents of S.H.I.E.L.D.'' * Leopold "Butters" Stotch, a character on the television series ''South Park'' * General Leopold von Flockenstuffen, a character in the BBC sitcom Allo 'Allo!'' * Leopold the Cat, Russian cartoon character Other arts, entertainment, and media * Leopold (prize), a biennial German prize for music for children * ''Kate & Leopold'', 2001 romantic comedy film * ''King Leopold's Ghost'', popular history book by Adam Hochschild * "King Leopold's Soliloquy", 1905 pamphlet by Mark Twain. * ''Leopold the Cat'', television series * Léopold Nord & Vous, Belgian musical band Brands and enterprises *Leopold (publisher), a Netherlands-b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pasarow Award
The Robert J. And Claire Pasarow Foundation Medical Research Awards were awarded annually for distinguished accomplishment in areas of investigation that included neuropsychiatry, cardiovascular disease, and cancer research. The program ran from 1987 to 2013. Each area of research was allocated US$50,000 to award to its winners. History of the award The Pasarow Foundation was created in 1987 by Mr. and Mrs. Pasarow of Beverly Hills, California, to stimulate medical and scientific research. Robert Pasarow was the founder and former president/CEO/chairman of the board of CHB Foods, Inc. The Pasarows established the Claire and Robert J. Pasarow Cancer Laboratory at the Kenneth Norris Jr. Cancer Hospital and Research Institute at the University of Southern California as well as the Pasarow Mass Spectrometry Laboratory at the University of California Los Angeles. Robert J. Pasarow, now deceased, was the founding president and chairman of the foundation and Claire Pasarow, also deceas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albany Medical Center Prize
The Albany Medical Center Prize in Medicine and Biomedical Research is the United States' second highest value prize in medicine and biomedical research, awarded by the Albany Medical Center. Among prizes for medicine worldwide, the Albany Medical Center Prize is the fourth most lucrative (after the $3 million Breakthrough Prize in Life Sciences, the $1.2 million Nobel Prize in Medicine and the $1 million Shaw Prize in life science and medicine). Awarded annually, the $500,000 prize is bestowed to any physician or scientist, or group, whose work has led to significant advances in the fields of health care and scientific research with demonstrated translational benefits applied to improved patient care. The prize is a legacy to its founder, the late Morris "Marty" Silverman. At the inaugural awards ceremony in Albany, NY in March 2001, Silverman started a tradition that will be carried on for one hundred years, the duration of the Prize. Silverman's promise was to light one candle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
