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Alaskapox Virus
''Alaskapox virus'' is a species of the ''Orthopoxvirus'' genus, first documented in 2015 in the United States state of Alaska. As of 2022, there are four known cases of illness caused by the virus, all of which occurred in Fairbanks North Star Borough, with none resulting in hospitalization or death. Discovery In July 2015, a woman visited a clinic in Fairbanks, Alaska, with lesions that were confirmed to contain an ''Orthopox'' virus but did not match any known members of the genus. Subsequent genetic analysis established that the woman, who recovered, had been infected with a novel ''Orthopox'' virus. The name ''Alaskapox virus'' was proposed after full analysis of its genome was published in 2019. Subsequent cases In 2020, the Alaska Department of Health and Social Services announced the second known infection of ''Alaskapox'' in another Fairbanks woman. Two additional cases were identified in the Fairbanks area in the summer of 2021. All four known cases were mild, not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orthopoxvirus
''Orthopoxvirus'' is a genus of viruses in the family ''Poxviridae'' and subfamily ''Chordopoxvirinae''. Vertebrates, including mammals and humans, and arthropods serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include smallpox, cowpox, horsepox, camelpox, and monkeypox. The most widely known member of the genus is '' Variola virus'', which causes smallpox. It was eradicated globally by 1977, through the use of ''Vaccinia virus'' as a vaccine. The most recently described species is the ''Alaskapox virus'', first isolated in 2015. Microbiology Structure Orthopoxviruses are enveloped with brick-shaped geometries and virion dimensions around 200 nm wide and 250 nm long. Genome Member viruses have linear DNA genomes around 170–250 kb in length. Lifecycle Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs), which mediate cellula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fairbanks North Star Borough
The Fairbanks North Star Borough is a borough located in the state of Alaska. As of the 2020 census, the population was 95,665, down from 97,581 in 2010. The borough seat is Fairbanks. The borough's land area is slightly smaller than that of the state of New Jersey. Fairbanks North Star Borough comprises the Fairbanks, AK, Metropolitan Statistical Area, which is one of only two metropolitan areas in Alaska. The borough is home to the University of Alaska Fairbanks, Fort Wainwright and Eielson Air Force Base. Geography The borough has a total area of , of which is land and (1.4%) is water. Adjacent boroughs and census areas * Yukon-Koyukuk Census Area, Alaska – north * Southeast Fairbanks Census Area, Alaska – southeast * Denali Borough, Alaska – southwest Government and politics The assembly is the borough's governing body, or legislative branch. The assembly consists of nine members who are elected at-large (borough-wide), serving three-year terms. The boro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fairbanks, Alaska
Fairbanks is a home rule city and the borough seat of the Fairbanks North Star Borough in the U.S. state of Alaska. Fairbanks is the largest city in the Interior region of Alaska and the second largest in the state. The 2020 Census put the population of the city proper at 32,515, and the population of the Fairbanks North Star Borough at 95,655 making it the second most populous metropolitan area in Alaska after Anchorage. The Metropolitan Statistical Area encompasses all of the Fairbanks North Star Borough and is the northernmost Metropolitan Statistical Area in the United States, located by road ( by air) south of the Arctic Circle. Fairbanks is home to the University of Alaska Fairbanks, the founding campus of the University of Alaska system. History Native American presence Athabascan peoples have used the area for thousands of years, although there is no known permanent Alaska Native settlement at the site of Fairbanks. An archaeological site excavated on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alaska Department Of Health And Social Services
The Alaska Department of Health and Social Services is a state agency of Alaska, headquartered in Juneau, Alaska, Juneau. ". Divisions * Alaska Division of Juvenile JusticeReferences External links Alaska Department of Health and Social Services State agencies of Alaska, Health State departments of health of the United States Medical and health organizations based in Alaska {{Alaska-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymph Node
A lymph node, or lymph gland, is a kidney-shaped organ of the lymphatic system and the adaptive immune system. A large number of lymph nodes are linked throughout the body by the lymphatic vessels. They are major sites of lymphocytes that include B and T cells. Lymph nodes are important for the proper functioning of the immune system, acting as filters for foreign particles including cancer cells, but have no detoxification function. In the lymphatic system a lymph node is a secondary lymphoid organ. A lymph node is enclosed in a fibrous capsule and is made up of an outer cortex and an inner medulla. Lymph nodes become inflamed or enlarged in various diseases, which may range from trivial throat infections to life-threatening cancers. The condition of lymph nodes is very important in cancer staging, which decides the treatment to be used and determines the prognosis. Lymphadenopathy refers to glands that are enlarged or swollen. When inflamed or enlarged, lymph nodes can be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chordopoxvirinae
''Chordopoxvirinae'' is a subfamily of viruses in the family ''Poxviridae''. Humans, vertebrates, and arthropods serve as natural hosts. Currently, 52 species are placed in this subfamily, divided among 18 genera. Diseases associated with this subfamily include smallpox. Four genera in this subfamily contain species that infect humans: ''Molluscipoxvirus, Orthopoxvirus, Parapoxvirus'', and ''Yatapoxvirus''. Virology The virions are generally enveloped though the intracellular mature virion form of the virus, which contains a different envelope, and is also infectious. They vary in their shape depending upon the species, but are generally shaped like a brick or as an oval form similar to a rounded brick because they are wrapped by the endoplasmic reticulum. The virion is exceptionally large, around 200 nm in diameter and 300 nm in length, and carries its genome in a single, double-stranded segment of DNA. Genomes are linear, around 130-375kb in length. Lifecycle Viral r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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