Aggressive Digital Papillary Adenocarcinoma
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Aggressive Digital Papillary Adenocarcinoma
Aggressive digital papillary adenocarcinoma is a cutaneous condition characterized by an aggressive malignancy involving the digit between the nailbed and the distal interphalangeal joint spaces. See also * Mucinous carcinoma * List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against t ... References Epidermal nevi, neoplasms, and cysts {{Epidermal-growth-stub ...
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Malignancy
Malignancy () is the tendency of a medical condition to become progressively worse. Malignancy is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous ''benign'' tumor in that a malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues. A benign tumor has none of those properties. Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by genome instability, so that cancers, as assessed by whole genome sequencing, frequently have between 10,000 and 100,000 mutations in their entire genomes. Cancers usually show tumour heterogeneity, containing multiple subclones. They also frequently have reduced expression of DNA repair enzymes due to epigenetic methylation of DNA repair genes or altered microRNAs that control DNA repair gene expression. Tumours can be detected through the visual ...
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Mucinous Carcinoma
A mucinous neoplasm (also called colloid neoplasm) is an abnormal and excessive growth of tissue (neoplasia) with associated mucin (a fluid that sometimes resembles thyroid colloid). It arises from epithelial cells that line certain internal organs and skin, and produce mucin (the main component of mucus). A malignant mucinous neoplasm is called a mucinous carcinoma. For example, for ovarian mucinous tumors, approximately 75% are benign, 10% are borderline and 15% are malignant. Mucinous carcinoma Over 40 percent of all mucinous carcinomas are colorectal. When found within the skin, mucinous carcinoma is commonly a round, elevated, reddish, and sometimes ulcerated mass, usually located on the head and neck. File:Histopathology of mucinous invasive ductal carcinoma of the breast.jpg, Mucinous carcinoma of the breast: Gross pathology (upper left) of mucinous carcinoma shows gelatinous areas. Histopathology shows clusters or nests of tumor cells floating in pools of extracellular ...
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List Of Cutaneous Conditions
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment. The skin weighs an average of four kilograms, covers an area of two square metres, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin.Burns, Tony; ''et al''. (2006) ''Rook's Textbook of Dermatology CD-ROM''. Wiley-Blackwell. . Within the latter type, the hairs occur in structures called pilosebaceous units, each with hair follicle, sebaceous gland, and associated arrector pili muscle. In the embryo, the epidermis, hair, and glands form from the ectoderm, which is chemically influenced by the underlying mesoderm th ...
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