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Addiction Rare In Patients Treated With Narcotics
"Addiction Rare in Patients Treated with Narcotics" is the title of a letter to the editor written by Jane Porter and Hershel Jick and published in the January 10, 1980, issue of ''The New England Journal of Medicine''. The letter analyzed data on patients who had been treated with opioids in a hospital setting, and concluded that addiction was uncommon among such patients. It has since been frequently misrepresented to claim that opioids are not addictive when prescribed for use at home, which has been blamed for contributing to the opioid epidemic in the United States. Content The letter reported on an examination of medical files of patients who had been hospitalized and treated with small doses of opioids. The authors concluded that of the 11,882 patients who received at least one narcotic drug, only four of them had developed a "reasonably well documented" addiction among patients who had no history of addiction. Its text read, in its entirety: Influence The article was subse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Letter To The Editor
A letter to the editor (LTE) is a letter sent to a publication about an issue of concern to the reader. Usually, such letters are intended for publication. In many publications, letters to the editor may be sent either through conventional mail or electronic mail. Letters to the editor are most frequently associated with newspapers and news magazines, however, they are sometimes published in other periodicals such as entertainment and technical magazines and academic journals. Radio and television stations may also receive such letters, which are sometimes read on the air, particularly on news commentary broadcasts or on talk radio. In this presentation form the letter to the editor can also be described as viewer mail or listener mail, depending on the medium. Subject matter The subject matter of letters to the editor vary widely. However, the most common topics include: * Supporting or opposing a stance taken by the publication in its editorial or by a columnist, or r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
OxyContin
Oxycodone, sold under various brand names such as Roxicodone and OxyContin (which is the extended release form), is a strong, semi-synthetic opioid used medically for treatment of moderate to severe pain. It is highly addictive and a commonly abused drug. It is usually taken by mouth, and is available in immediate-release and controlled-release formulations. Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation. In the United Kingdom, it is available by injection. Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin. Common side effects include euphoria, constipation, nausea, vomiting, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating. Severe side effects may include addiction and dependence, substance abuse, irritability, depression or mania, delirium, hallucinations, hypoventilation, gastroparesis, brady ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Letters (message)
Letter, letters, or literature may refer to: Characters typeface * Letter (alphabet), a character representing one or more of the sounds used in speech; any of the symbols of an alphabet. * Letterform, the graphic form of a letter of the alphabet, either as written or in a particular type font. * Rehearsal letter in an orchestral score Communication * Letter (message), a form of written communication ** Mail * Letters, the collected correspondence of a writer or historically significant person ** Maktubat (other), the Arabic word for collected letters **Pauline epistles, addressed by St. Paul to various communities or congregations, such as "Letters to the Galatians" or "Letters to the Corinthians", and part of the canonical books of the Bible * The letter as a form of second-person literature; see Epistle ** Epistulae (Pliny) ** Epistolary novel, a long-form fiction composed of letters (epistles) * Open letter, a public letter as distinguished from private correspon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opioids
Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid use disorder, reversing opioid overdose, and suppressing cough. Extremely potent opioids such as carfentanil are approved only for veterinary use. Opioids are also frequently used non-medically for their euphoric effects or to prevent withdrawal. Opioids can cause death and have been used for executions in the United States. Side effects of opioids may include itchiness, sedation, nausea, respiratory depression, constipation, and euphoria. Long-term use can cause tolerance, meaning that increased doses are required to achieve the same effect, and physical dependence, meaning that abruptly discontinuing the drug leads to unpleasant withdrawal symptoms. The euphoria attracts recreational use, and frequent, escalating recreational u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pain Management
Pain management is an aspect of medicine and health care involving relief of pain (pain relief, analgesia, pain control) in various dimensions, from acute and simple to chronic and challenging. Most physicians and other health professionals provide some pain control in the normal course of their practice, and for the more complex instances of pain, they also call on additional help from a specific medical specialty devoted to pain, which is called pain medicine. Pain management often uses a multidisciplinary approach for easing the suffering and improving the quality of life of anyone experiencing pain, whether acute pain or chronic pain. Relief of pain in general (analgesia) is often an acute affair, whereas managing chronic pain requires additional dimensions. The typical pain management team includes medical practitioners, pharmacists, clinical psychologists, physiotherapists, occupational therapists, recreational therapists, physician assistants, nurses, and dentists. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1980 Documents
__NOTOC__ Year 198 (CXCVIII) was a common year starting on Sunday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Sergius and Gallus (or, less frequently, year 951 ''Ab urbe condita''). The denomination 198 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire *January 28 **Publius Septimius Geta, son of Septimius Severus, receives the title of Caesar. **Caracalla, son of Septimius Severus, is given the title of Augustus. China *Winter – Battle of Xiapi: The allied armies led by Cao Cao and Liu Bei defeat Lü Bu; afterward Cao Cao has him executed. By topic Religion * Marcus I succeeds Olympianus as Patriarch of Constantinople (until 211). Births * Lu Kai (or Jingfeng), Chinese official and general (d. 269) * Quan Cong, Chinese general and advisor (d. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academic Journal Articles
An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary or tertiary higher learning (and generally also research or honorary membership). The name traces back to Plato's school of philosophy, founded approximately 385 BC at Akademia, a sanctuary of Athena, the goddess of wisdom and skill, north of Athens, Greece. Etymology The word comes from the ''Academy'' in ancient Greece, which derives from the Athenian hero, ''Akademos''. Outside the city walls of Athens, the gymnasium was made famous by Plato as a center of learning. The sacred space, dedicated to the goddess of wisdom, Athena, had formerly been an olive grove, hence the expression "the groves of Academe". In these gardens, the philosopher Plato conversed with followers. Plato developed his sessions into a method of teaching philosophy and in 387 BC, established what is known today as the Old Academy. By extension, ''academia'' has come to mean the acc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Juurlink
David Juurlink ( ; born New Glasgow, Nova Scotia) is a Canadian pharmacologist and internist. He is head of the Clinical Pharmacology and Toxicology division at Sunnybrook Health Sciences Centre in Toronto, Ontario, as well as a medical toxicologist at the Ontario Poison Centre and a scientist at the Institute for Clinical Evaluative Sciences. He is known for researching adverse effects caused by drug interactions, with some of this research funded by a New Investigator Award from the Canadian Institutes for Health Research. He has been very critical of his fellow physicians' regular prescribing of dangerous opioids like Tramadol and fentanyl. In June 2017, he published a letter analyzing citations to "Addiction Rare in Patients Treated with Narcotics", a 1980 letter in ''The New England Journal of Medicine'' that has often been cited to claim that opioids like OxyContin Oxycodone, sold under various brand names such as Roxicodone and OxyContin (which is the extended relea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Purdue Pharma
Purdue Pharma L.P., formerly the Purdue Frederick Company, is an American privately held pharmaceutical company founded by John Purdue Gray. It was owned principally by members of the Sackler family as descendants of Mortimer and Raymond Sackler. In 2007, it paid out one of the largest fines ever levied against a pharmaceutical firm for misleading the public about how addictive the drug OxyContin was compared to other pain medications. In September 2021 Purdue Pharma announced that it rebrand itself as Knoa Pharma. Although the company shifted its focus to abuse-deterrent formulations, Purdue continued to market and sell opioids as late as 2019 and continued to be involved in lawsuits around the opioid epidemic in the United States. Purdue filed for Chapter 11 bankruptcy protection on September 15, 2019, in New York City. On October 21, 2020, it was reported that Purdue had reached a settlement potentially worth US$8.3 billion, admitting that it "knowingly and intentionally c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hershel Jick
Hershel M. Jick (born December 1, 1931) is an American medical researcher and associate professor of medicine at Boston University School of Medicine, where he was formerly the director of the Boston Collaborative Drug Surveillance Program. Education Jick graduated from Harvard Medical School in 1956 and completed an internal medicine residency and clinical pharmacology fellowship. Career Jick is known for researching the negative and positive effects of pharmaceutical drugs. A 1977 study by him and his assistant Jane Porter reported that no more than one patient per 3,600 died because of incorrect drug prescriptions. The "Porter–Jick study" was mentioned in the Hulu miniseries ''Dopesick'' and Jick was portrayed by theatre actor Mark Jacoby. In 1980, Jick and Porter published the letter "Addiction Rare in Patients Treated with Narcotics", which has been cited to argue that opioid Opioids are substances that act on opioid receptors to produce morphine-like effects. M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Time (magazine)
''Time'' (stylized in all caps) is an American news magazine based in New York City. For nearly a century, it was published Weekly newspaper, weekly, but starting in March 2020 it transitioned to every other week. It was first published in New York City on March 3, 1923, and for many years it was run by its influential co-founder, Henry Luce. A European edition (''Time Europe'', formerly known as ''Time Atlantic'') is published in London and also covers the Middle East, Africa, and, since 2003, Latin America. An Asian edition (''Time Asia'') is based in Hong Kong. The South Pacific edition, which covers Australia, New Zealand, and the Pacific Islands, is based in Sydney. Since 2018, ''Time'' has been published by Time USA, LLC, owned by Marc Benioff, who acquired it from Meredith Corporation. History ''Time'' has been based in New York City since its first issue published on March 3, 1923, by Briton Hadden and Henry Luce. It was the first weekly news magazine in the United St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific American
''Scientific American'', informally abbreviated ''SciAm'' or sometimes ''SA'', is an American popular science magazine. Many famous scientists, including Albert Einstein and Nikola Tesla, have contributed articles to it. In print since 1845, it is the oldest continuously published magazine in the United States. ''Scientific American'' is owned by Springer Nature, which in turn is a subsidiary of Holtzbrinck Publishing Group. History ''Scientific American'' was founded by inventor and publisher Rufus Porter in 1845 as a four-page weekly newspaper. The first issue of the large format newspaper was released August 28, 1845. Throughout its early years, much emphasis was placed on reports of what was going on at the U.S. Patent Office. It also reported on a broad range of inventions including perpetual motion machines, an 1860 device for buoying vessels by Abraham Lincoln, and the universal joint which now can be found in nearly every automobile manufactured. Current issues inc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
