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Adaptor Protein 1
Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein (AP) complexes. There are several types of adaptin, each related to a different AP complex. Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin. The adaptin is a heterotetramer consisting of two large adaptins (beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma): * complex 1 ** AP1B1 ** AP1G1 ** AP1G2 ** AP1M1 ** AP1M2 ** AP1S1 ** AP1S2 *AP1S3* complex 2 ** AP2A1 ** AP2A2 ** AP2B1 ** AP2M1 ** AP2S1 * complex 3 ** AP3B1 ** AP3B2 ** AP3D1 ** AP3M1 *AP3M2** AP3S1 ** AP3S2 * complex 4 ** AP4B1 ** AP4E1 ** AP4M1 ** AP4S1 * complex 5 ** AP5Z1 AP-5 complex subunit zeta (AP5Z1) is a protein that in humans is encoded by the ''AP5Z1'' gene. Function The protein encoded by this ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clathrin Adaptor Proteins
Clathrin adaptor proteins, also known as adaptins, are vesicular transport adaptor proteins associated with clathrin. These proteins are synthesized in the ribosomes, processed in the endoplasmic reticulum and transported from the Golgi apparatus to the trans-Golgi network, and from there via small carrier vesicles to their final destination compartment. The association between adaptins and clathrin are important for vesicular cargo selection and transporting. Clathrin coats contain both clathrin (acts as a scaffold) and adaptor complexes that link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Therefore, adaptor proteins are responsible for the recruitment of cargo molecules into a growing clathrin-coated pits. The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |