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Acoustic Trauma
Acoustic trauma is the sustainment of an injury to the eardrum as a result of a very loud noise. Its scope usually covers loud noises with a short duration, such as an explosion, gunshot or a burst of loud shouting. Quieter sounds that are concentrated in a narrow frequency may also cause damage to specific frequency receptors. The range of severity can vary from pain to hearing loss. Acute acoustic trauma can be treated by combining hyperbaric oxygen therapy (HBO) with corticosteroids. Acute noise exposure causes inflammation and lower oxygen supply in the inner ear. Corticosteroids hinder the inflammatory reaction and HBO provides an adequate oxygen supply. This therapy has been shown to be effective when initiated within three days after acoustic trauma. Therefore, this condition is considered an ENT emergency. Signs and Symptoms Hazardous noise causes injury to the hearing mechanisms in the inner ear. Acoustic trauma may result in sensorineural HL (SNHL) that is either te ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Audiology
Audiology (from Latin , "to hear"; and from Greek , ''-logia'') is a branch of science that studies hearing, balance, and related disorders. Audiologists treat those with hearing loss and proactively prevent related damage. By employing various testing strategies (e.g. behavioral hearing tests, otoacoustic emission measurements, and electrophysiologic tests), audiologists aim to determine whether someone has normal sensitivity to sounds. If hearing loss is identified, audiologists determine which portions of hearing (high, middle, or low frequencies) are affected, to what degree (severity of loss), and where the lesion causing the hearing loss is found (outer ear, middle ear, inner ear, auditory nerve and/or central nervous system). If an audiologist determines that a hearing loss or vestibular abnormality is present, they will provide recommendations for interventions or rehabilitation (e.g. hearing aids, cochlear implants, appropriate medical referrals). In addition to diagn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Afferent Nerve Fiber
Afferent nerve fibers are the axons (nerve fibers) carried by a sensory nerve that relay sensory information from sensory receptors to regions of the brain. Afferent projections ''arrive'' at a particular brain region. Efferent nerve fibers are carried by efferent nerves and ''exit'' a region to act on muscles and glands. In the peripheral nervous system afferent and efferent nerve fibers are part of the somatic nervous system and arise from outside of the spinal cord. Sensory nerves carry the afferent fibers to enter into the spinal cord, and motor nerves carry the efferent fibers out of the spinal cord to act on skeletal muscles. In the central nervous system non-motor efferents are carried in efferent nerves to act on glands. Structure Afferent neurons are pseudounipolar neurons that have a single process leaving the cell body dividing into two branches: the long one towards the sensory organ, and the short one toward the central nervous system (e.g. spinal cord). The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Israel Defense Forces
The Israel Defense Forces (IDF; he, צְבָא הַהֲגָנָה לְיִשְׂרָאֵל , ), alternatively referred to by the Hebrew-language acronym (), is the national military of the Israel, State of Israel. It consists of three service branches: the Israeli Ground Forces, the Israeli Air Force, and the Israeli Navy. It is the sole military wing of the Israeli security forces, Israeli security apparatus, and has no civilian jurisdiction within Israel. The IDF is headed by the Chief of the General Staff (Israel), Chief of the General Staff, who is subordinate to the Ministry of Defense (Israel), Israeli Defense Minister. On the orders of David Ben-Gurion, the IDF was formed on 26 May 1948 and began to operate as a Conscription in Israel, conscript military, drawing its initial recruits from the already-existing paramilitaries of the Yishuv—namely Haganah, the Irgun, and Lehi (militant group), Lehi. Since its formation shortly after the Israeli Declaration of Independen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Presbycusis
Presbycusis (also spelled presbyacusis, from Greek πρέσβυς ''presbys'' "old" + ἄκουσις ''akousis'' "hearing"), or age-related hearing loss, is the cumulative effect of aging on hearing. It is a progressive and irreversible bilateral symmetrical age-related sensorineural hearing loss resulting from degeneration of the cochlea or associated structures of the inner ear or auditory nerves. The hearing loss is most marked at higher frequencies. Hearing loss that accumulates with age but is caused by factors other than normal aging ( nosocusis and sociocusis) is not presbycusis, although differentiating the individual effects of distinct causes of hearing loss can be difficult. The cause of presbycusis is a combination of genetics, cumulative environmental exposures and pathophysiological changes related to aging. At present there are no preventive measures known; treatment is by hearing aid or surgical implant. Presbycusis is the most common cause of hearing loss, affec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Audiometry
Audiometry () is a branch of audiology and the science of measuring hearing acuity for variations in sound intensity and pitch and for tonal purity, involving thresholds and differing frequencies. Typically, audiometric tests determine a subject's hearing levels with the help of an audiometer, but may also measure ability to discriminate between different sound intensities, recognize pitch, or distinguish speech from background noise. Acoustic reflex and otoacoustic emissions may also be measured. Results of audiometric tests are used to diagnose hearing loss or diseases of the ear, and often make use of an audiogram. History The basic requirements of the field were to be able to produce a repeating sound, some way to attenuate the amplitude, a way to transmit the sound to the subject, and a means to record and interpret the subject's responses to the test. Mechanical "acuity meters" and tuning forks For many years there was desultory use of various devices capable of produc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ossicles
The ossicles (also called auditory ossicles) are three bones in either middle ear that are among the smallest bones in the human body. They serve to transmit sounds from the air to the fluid-filled labyrinth (cochlea). The absence of the auditory ossicles would constitute a moderate-to-severe hearing loss. The term "ossicle" literally means "tiny bone". Though the term may refer to any small bone throughout the body, it typically refers to the malleus, incus, and stapes (hammer, anvil, and stirrup) of the middle ear. Structure The ossicles are, in order from the eardrum to the inner ear (from superficial to deep): the malleus, incus, and stapes, terms that in Latin are translated as "the hammer, anvil, and stirrup". * The malleus ( la, "hammer") articulates with the incus through the incudomalleolar joint and is attached to the tympanic membrane (eardrum), from which vibrational sound pressure motion is passed. * The incus ( la, "anvil") is connected to both the other bones. * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Improvised Explosive Device
An improvised explosive device (IED) is a bomb constructed and deployed in ways other than in conventional military action. It may be constructed of conventional military explosives, such as an artillery shell, attached to a detonating mechanism. IEDs are commonly used as roadside bombs, or homemade bombs. IEDs are generally done in these terrorism operations or in asymmetric unconventional warfare by insurgent guerrillas or commando forces in a theatre of operations. In the Iraq War (2003–2011), insurgents used IEDs extensively against U.S.-led forces and, by the end of 2007, IEDs were responsible for approximately 63% of coalition deaths in Iraq. They were also used in Afghanistan by insurgent groups, and caused over 66% of coalition casualties in the 2001–2021 Afghanistan War. IEDs were also used frequently by the Liberation Tigers of Tamil Eelam (LTTE) in Sri Lanka during the Sri Lankan Civil War. Background An IED is a bomb fabricated in an improvised manner ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corti
Corti is an Italian surname. Notable people with the surname include: *Alfonso Giacomo Gaspare Corti (1822–1876), Italian anatomist (see also Organ of Corti) *Antonio Corti (born 1963), Argentine boxer *Axel Corti (1933–1993), Austrian writer and film director * Bonaventura Corti (1729–1813), Italian priest and naturalist *Claudio Corti (climber), Italian mountaineer *Eugenio Corti (1921–2014), Italian novelist * Horacio Pietragalla Corti *Jean Corti (1929–2015), Italian-French accordionist and composer *Jesse Corti, American voice actor *Lodovico, Count Corti (1823–1888), Italian diplomat *Lucille Teasdale-Corti (1929–1996), Canadian physician and international aid worker See also *Monchio delle Corti, a municipality in the Province of Parma, Italy *José Corti, a Paris library and publishing house *Organ of Corti The organ of Corti, or spiral organ, is the receptor organ for hearing and is located in the mammalian cochlea. This highly varied strip of epithelial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synaptopathy
A synaptopathy is a disease of the brain, spinal cord or peripheral nervous system relating to the dysfunction of synapses. This can arise as a result of a mutation in a gene encoding a synaptic protein such as an ion channel, neurotransmitter receptor, or a protein involved in neurotransmitter release. It can also arise as a result of an autoantibody targeting a synaptic protein. Synaptopathies caused by ion channel mutations are also known as synaptic channelopathies. An example is episodic ataxia. Myasthenia gravis is an example of an autoimmune synaptopathy. Some toxins also affect synaptic function. Tetanus toxin and botulinum toxin affect neurotransmitter release. Tetanus toxin can enter the body via a wound, and botulinum toxin can be ingested or administered therapeutically to alleviate dystonia or as cosmetic treatment. Another example of synaptopathy occurs in the auditory system. This cochlear synaptopathy has been seen after prolonged noise exposure in both pri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cochlea
The cochlea is the part of the inner ear involved in hearing. It is a spiral-shaped cavity in the bony labyrinth, in humans making 2.75 turns around its axis, the modiolus. A core component of the cochlea is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating the fluid chambers in the coiled tapered tube of the cochlea. The name cochlea derives . Structure The cochlea (plural is cochleae) is a spiraled, hollow, conical chamber of bone, in which waves propagate from the base (near the middle ear and the oval window) to the apex (the top or center of the spiral). The spiral canal of the cochlea is a section of the bony labyrinth of the inner ear that is approximately 30 mm long and makes 2 turns about the modiolus. The cochlear structures include: * Three ''scalae'' or chambers: ** the vestibular duct or ''scala vestibuli'' (containing perilymph), which lies superior to the cochlear duct and abuts the oval window ** the ty ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spiral Ganglion
The spiral (cochlear) ganglion is a group of neuron cell bodies in the modiolus, the conical central axis of the cochlea. These bipolar neurons innervate the hair cells of the organ of Corti. They project their axons to the ventral and dorsal cochlear nuclei as the cochlear nerve, a branch of the vestibulocochlear nerve (CN VIII). Structure Neurons whose cell bodies lie in the spiral ganglion are strung along the bony core of the cochlea, and send fibers (axons) into the central nervous system (CNS). These bipolar neurons are the first neurons in the auditory system to fire an action potential, and supply all of the brain's auditory input. Their dendrites make synaptic contact with the base of hair cells, and their axons are bundled together to form the auditory portion of eighth cranial nerve. The number of neurons in the spiral ganglion is estimated to be about 35,000–50,000. Two apparent subtypes of spiral ganglion cells exist. Type I spiral ganglion cells comprise the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Excitotoxicity
In excitotoxicity, nerve cells suffer damage or death when the levels of otherwise necessary and safe neurotransmitters such as glutamate become pathologically high, resulting in excessive stimulation of receptors. For example, when glutamate receptors such as the NMDA receptor or AMPA receptor encounter excessive levels of the excitatory neurotransmitter, glutamate, significant neuronal damage might ensue. Excess glutamate allows high levels of calcium ions (Ca2+) to enter the cell. Ca2+ influx into cells activates a number of enzymes, including phospholipases, endonucleases, and proteases such as calpain. These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA. In evolved, complex adaptive systems such as biological life it must be understood that mechanisms are rarely, if ever, simplistically direct. For example, NMDA in subtoxic amounts induces neuronal survival of otherwise toxic levels of glutamate. Excitotoxicity may be inv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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