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Acidic Leucine-rich Nuclear Phosphoprotein 32 Family Member A
Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ''ANP32A'' gene. It is one of the targets of an oncomiR, MIRN21. Interactions Acidic leucine-rich nuclear phosphoprotein 32 family member A has been shown to interact with MAP1B, TAF1A and Protein SET Protein SET, also known as Protein SET 1, is a protein that in humans is encoded by the ''SET'' gene. Interactions Protein SET has been shown to interact with: * Acidic leucine-rich nuclear phosphoprotein 32 family member A, * CDK5R1, * KLF5 .... See also * ANP32B, ANP32C, ANP32D, ANP32E References Further reading * * * * * * * * * * * * * * * * * External links * {{Gene-15-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MIRN21
microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the ''MIR21'' gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly conserved throughout evolution. The human microRNA-21 gene is located on plus strand of chromosome 17q23.2 (55273409–55273480) within a coding gene TMEM49 (also called vacuole membrane protein). Despite being located in intronic regions of a coding gene in the direction of transcription, it has its own promoter regions and forms a ~3433-nt long primary transcript of miR-21 (known as pri-miR-21) which is independently transcribed. The stem–loop precursor of miR-21(pre-miR-21) resides between nucleotides 2445 and 2516 of pri-miR-21. Mature miR-21 Pri-miR-21 is cut by the endonuclease Drosha in the nucleus to produce pre-miR-21, which is exported into the cytosol. This pre-miR-21 is then cut into a short RNA duplex by Dicer in the cytosol. Although abundance of both str ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MAP1B
Microtubule-associated protein 1B is a protein that in humans is encoded by the ''MAP1B'' gene. Function This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described. Interactions MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A and RASSF1 Ras association domain-containing protein 1 is a protein that in humans is encoded by the ''RASSF1'' gene. Function This gene encodes a protein similar to the RA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the ''TAF1A'' gene. Function Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as selective factor 1 (SL1), binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified. Interactions TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A and Protein SET Protein SET, also known as Protein SET 1, is a protein that in humans is encoded by the ''SET'' gene. Interactions Protein SET has been shown to interact with: * Acidic leucine-rich nuclear phosphoprotein 32 family mem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein SET
Protein SET, also known as Protein SET 1, is a protein that in humans is encoded by the ''SET'' gene. Interactions Protein SET has been shown to interact with: * Acidic leucine-rich nuclear phosphoprotein 32 family member A, * CDK5R1, * KLF5, * NME1, and * TAF1A TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the ''TAF1A'' gene. Function Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TA .... References Further reading * * * * * * * * * * * * * * * * * Histone Acetyltransferase Inhibitor {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANP32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) also known as "acidic protein rich in leucines" (APRIL) is a protein that in humans is encoded by the ''ANP32B'' gene. APRIL is also the acronym used for an entirely different protein, TNFSF13, a member of the tumor necrosis factor superfamily whose alternative name, A PRoliferation Inducing Ligand, shares the same acronym as that for ANP32B See also * ANP32A, ANP32C, ANP32D Acidic leucine-rich nuclear phosphoprotein 32 family member D is a protein that in humans is encoded by the ''ANP32D'' gene. Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast ca ..., ANP32E References External links * Further reading * * * * * * * * * * * {{gene-9-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANP32C
Acidic leucine-rich nuclear phosphoprotein 32 family member C is a protein that in humans is encoded by the ''ANP32C'' gene. Function Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. See also * ANP32A, ANP32B, ANP32D Acidic leucine-rich nuclear phosphoprotein 32 family member D is a protein that in humans is encoded by the ''ANP32D'' gene. Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast ca ..., ANP32E R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANP32D
Acidic leucine-rich nuclear phosphoprotein 32 family member D is a protein that in humans is encoded by the ''ANP32D'' gene. Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. See also * ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ''ANP32A'' gene. It is one of the targets of an oncomiR, MIRN21. Interactions Acidic leucine-rich nuclear phosphoprotein 32 family member ..., ANP32B, ANP32C, ANP32E References Further reading * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
