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ATC Code R06
R06A Antihistamines for systemic use R06AA Aminoalkyl ethers :R06AA01 Bromazine :R06AA02 Diphenhydramine :R06AA04 Clemastine :R06AA06 Chlorphenoxamine :R06AA07 Diphenylpyraline :R06AA08 Carbinoxamine :R06AA09 Doxylamine :R06AA10 Trimethobenzamide :R06AA11 Dimenhydrinate :R06AA52 Diphenhydramine, combinations :R06AA54 Clemastine, combinations :R06AA56 Chlorphenoxamine, combinations :R06AA57 Diphenylpyraline, combinations :R06AA59 Doxylamine, combinations :R06AA61 Dimenhydrinate, combinations R06AB Substituted alkylamines :R06AB01 Brompheniramine :R06AB02 Dexchlorpheniramine :R06AB03 Dimetindene :R06AB04 Chlorphenamine :R06AB05 Pheniramine :R06AB06 Dexbrompheniramine :R06AB07 Talastine :R06AB51 Brompheniramine, combinations :R06AB52 Dexchlorpheniramine, combinations :R06AB54 Chlorphenamine, combinations :R06AB56 Dexbrompheniramine, combinations R06AC Substituted ethylene diamines :R06AC01 Mepyramine :R06AC02 Histapyrrodine :R06AC03 Chloropyramine :R06AC04 Tripelennamine :R0 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bromazine
Bromazine, sold under the brand names Ambodryl, Ambrodil, and Deserol among others, also known as bromodiphenhydramine, is an antihistamine and anticholinergic medication of the ethanolamine class. It is an analogue of diphenhydramine with a bromine substitution on one of the phenyl rings. Synthesis Grignard reaction between phenylmagnesium bromide and para-bromobenzaldehyde 122-91-4(1) gives p-bromobenzhydrol 9334-16-5(2). Halogenation with acetyl bromide in benzene solvent gives p-bromo-benzhydrylbromide 8066-89-2(3). Finally, etherification with deanol completed the synthesis of Bromazine (4). Side effects Continuous and/or cumulative use of anticholinergic Anticholinergics (anticholinergic agents) are substances that block the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system. These agents inhibit the parasympathetic nervous sys ... medications, including first-generation antihistamines, is asso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histapyrrodine
Histapyrrodine is an antihistamine with anticholinergic Anticholinergics (anticholinergic agents) are substances that block the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system. These agents inhibit the parasympathetic nervous sys ... properties. References H1 receptor antagonists 1-Pyrrolidinyl compounds Anilines {{respiratory-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isothipendyl
Isothipendyl is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic. It is nowadays scarcely used in the 1st line relief of allergies due to the anticholinergic side effect of somnolence but does have some limited use through topical application in the relief of insect bites and related itching (pruritus). See also * Promethazine *Prothipendyl Prothipendyl (brand names Dominal, Timovan, Tolnate), also known as azaphenothiazine or phrenotropin, is an anxiolytic, antiemetic, and antihistamine of the azaphenothiazine group which is marketed in Europe and is used to treat anxiety and agi ... References H1 receptor antagonists Pyridobenzthiazines {{dermatologic-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxomemazine
Oxomemazine is an antihistamine and anticholinergic of the phenothiazine chemical class Chemical classification systems attempt to classify elements or compounds according to certain chemical functional or structural properties. Whereas the structural properties are largely intrinsic, functional properties and the derived classificat ... for the treatment of cough. See also * Oxomemazine/guaifenesin References Phenothiazines Benzosulfones Dimethylamino compounds Antihistamines Sedatives {{respiratory-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mequitazine
Mequitazine (trade name Primalan) is an H1 antagonist and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis. It was patented in 1969 and came into medical use in 1976. Contraindications Severe liver disease; premature infants or full-term neonates. Special precautions Pregnancy, lactation; severe cardiovascular disorders; asthma; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly, children; epilepsy. May impair ability to drive or operate machinery. Adverse reactions CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely, rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, confusion, sleep and GI disturbances, tinnitus, hypotension, hair loss. Photosens ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thiazinam
Thiazinamium metilsulfate (INN) or thiazinam is an antihistamine. The USAN is thiazinamium chloride (with a different counterion). Synthesis Since many of the uses of antihistamines involve conditions such as rashes, which should be treatable by local application, there is some rationale for developing drugs for topical use. The known side effects of antihistamines could in principle be avoided if the drug were functionalized to avoid systemic absorption. The known poor absorption of quat salts make such derivatives attractive for nonabsorbable antihistamines for topical use. Thus, reaction of the well-known antihistaminic drug promethazine with methylchloride leads to thiazinamium chloride. See also * Phenothiazine *Promethazine Promethazine is a first-generation antihistamine, antipsychotic, sedative, and antiemetic used to treat allergies, insomnia, and nausea. It may also help with some symptoms associated with the common cold and may also be used for sedating peopl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydroxyethylpromethazine
Hydroxyethylpromethazine is an antihistamine with anticholinergic properties. It is structurally analogous to promethazine. See also * Promethazine Promethazine is a first-generation antihistamine, antipsychotic, sedative, and antiemetic used to treat allergies, insomnia, and nausea. It may also help with some symptoms associated with the common cold and may also be used for sedating people ... References H1 receptor antagonists Muscarinic antagonists Phenothiazines Quaternary ammonium compounds Primary alcohols {{respiratory-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methdilazine
Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class. Synthesis See also * Phenothiazine Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history. T ... References * * * The ring-contracted analog, methdilazine shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine. Phenothiazines Pyrrolidines H1 receptor antagonists {{respiratory-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thiethylperazine
Thiethylperazine (Torecan, Norzine) is an antiemetic of the phenothiazine class. It is an antagonist of dopamine receptors (DRD1, DRD2, DRD4) as well as of 5-HT2A, 5-HT2C receptors, mAChRs (1 through 5), α1 adrenergic receptor and H1 receptor. Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice. * Pharmacokinetics Distribution This drug is highly lipofilic and it binds with membranes and serum proteins (over 85%). It accumulates in organs with high blood flow and penetrates the placenta. It cannot be removed with dialysis. Metabolism It is mainly metabolised in the liver and only 3% is eliminated unchanged. Torecan's half-life is 12 h. Teratogenicity In toxic doses above the terapeutic window, it increases the rate of cleft palate occurrence. Antypsychotic activity Theithylperazine may possess antypsychotic activity due to the antagonism of 5-HT2 and D2 receptors. Because of this, it would not cause extrapyramid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Promethazine
Promethazine is a first-generation antihistamine, antipsychotic, sedative, and antiemetic used to treat allergies, insomnia, and nausea. It may also help with some symptoms associated with the common cold and may also be used for sedating people who are agitated or anxious, an effect that has led to some recreational use ( especially with codeine). Promethazine is available by mouth in syrup or tablet dosage forms, as a rectal suppository, or by injection into a muscle. Common side effects of promethazine include confusion and sleepiness; consumption of alcohol or other sedatives can make these symptoms worse. It is unclear if use of promethazine during pregnancy or breastfeeding is safe for the baby. Use of promethazine is not recommended in those less than two years old, due to potentially negative effects on breathing. Use of promethazine by injection into a vein is not recommended, due to potential skin damage. Promethazine is in the phenothiazine family of medications. It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alimemazine
Alimemazine (INN), also known as trimeprazine, (brand names Nedeltran, Panectyl, Repeltin, Therafene, Theraligene, Theralen, Theralene, Vallergan, Vanectyl, and Temaril), commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine). It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic. In the Russian Federation, it is marketed under the brand name Teraligen for the treatment of anxiety disorders (including GAD), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression, somatoform autonomic dysfunction and various neuroses. Alimemazine is not approved for use in humans in the United States. The combination of alimemazine and prednisolone (commonly sold under th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thonzylamine
Thonzylamine (or neohetramine) is an antihistamine and anticholinergic Anticholinergics (anticholinergic agents) are substances that block the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system. These agents inhibit the parasympathetic nervous sys ... used as an antipruritic. Synthesis See also * Zolamine References H1 receptor antagonists Phenol ethers Dimethylamino compounds Aminopyrimidines {{dermatologic-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
