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ALS Association
The ALS Association is an American nonprofit organization that funds global amyotrophic lateral sclerosis (ALS) research, provides care services and programs to people affected by ALS through its nationwide network of chapters, and works with ALS advocates around the country for state and federal policies that serve people living with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. The ALS Association is broken up into distinct chapters, each servicing a particular geographic area of the United States and all working under the umbrella of a national charter and administrator. Research The ALS Association has partnerships with Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital, ALS Finding a Cure, and the Muscular Dystrophy Association. Additionally, the organization is a research partner for Answer ALS (started by Steve Gleason), Target ALS (founded by Dan Doctoroff), and ALS ONE. The organization also provides funding for the ALS Resea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-profit
A nonprofit organization (NPO) or non-profit organisation, also known as a non-business entity, not-for-profit organization, or nonprofit institution, is a legal entity organized and operated for a collective, public or social benefit, in contrast with an entity that operates as a business aiming to generate a profit for its owners. A nonprofit is subject to the non-distribution constraint: any revenues that exceed expenses must be committed to the organization's purpose, not taken by private parties. An array of organizations are nonprofit, including some political organizations, schools, business associations, churches, social clubs, and consumer cooperatives. Nonprofit entities may seek approval from governments to be tax-exempt, and some may also qualify to receive tax-deductible contributions, but an entity may incorporate as a nonprofit entity without securing tax-exempt status. Key aspects of nonprofits are accountability, trustworthiness, honesty, and openness to eve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Axon
An axon (from Greek ἄξων ''áxōn'', axis), or nerve fiber (or nerve fibre: see spelling differences), is a long, slender projection of a nerve cell, or neuron, in vertebrates, that typically conducts electrical impulses known as action potentials away from the nerve cell body. The function of the axon is to transmit information to different neurons, muscles, and glands. In certain sensory neurons (pseudounipolar neurons), such as those for touch and warmth, the axons are called afferent nerve fibers and the electrical impulse travels along these from the periphery to the cell body and from the cell body to the spinal cord along another branch of the same axon. Axon dysfunction can be the cause of many inherited and acquired neurological disorders that affect both the peripheral and central neurons. Nerve fibers are classed into three typesgroup A nerve fibers, group B nerve fibers, and group C nerve fibers. Groups A and B are myelinated, and group C are unmyelinated. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LeBron James
LeBron Raymone James Sr. (; born December 30, 1984) is an American professional basketball player for the Los Angeles Lakers of the National Basketball Association (NBA). Nicknamed "King James", he is widely considered one of the greatest players ever and is often compared to Michael Jordan in debates over the greatest basketball player of all time. James has won four NBA championships, four NBA MVP awards, four NBA Finals MVP awards, three All-Star MVP awards, and two Olympic gold medals. James has scored the most points in the playoffs, the most career points (playoffs and regular season combined), and the second most regular season points, and has the seventh most career assists. He has been selected an NBA All-Star 18 times, to the All-NBA Team a record 18 times, and to the NBA All-Defensive First Team five times. He has competed in 10 NBA Finals, the third most all time, including eight consecutively between 2011 and 2018 (first four with Miami, second four with Clevel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benedict Cumberbatch
Benedict Timothy Carlton Cumberbatch (born 19 July 1976) is an English actor. Known for his work on screen and stage, he has received various accolades, including a British Academy Television Award, a Primetime Emmy Award and a Laurence Olivier Award. He has also been nominated for two Academy Awards, two British Academy Film Awards and four Golden Globe Awards. In 2014, ''Time'' magazine named him one of the 100 most influential people in the world, and in 2015, he was appointed a CBE at Buckingham Palace for services to the performing arts and to charity. Cumberbatch studied drama at the Victoria University of Manchester and obtained a Master of Arts in classical acting at the London Academy of Music and Dramatic Art. He began acting in Shakespearean theatre productions before making his West End debut in Richard Eyre's revival of ''Hedda Gabler'' in 2005. Since then, he has starred in Royal National Theatre productions of '' After the Dance'' (2010) and ''Frankenstei ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taylor Swift
Taylor Alison Swift (born December 13, 1989) is an American singer-songwriter. Her discography spans multiple genres, and her vivid songwriting—often inspired by her personal life—has received critical praise and wide media coverage. Born in West Reading, Pennsylvania, Swift moved to Nashville at age 14 to become a country artist. She signed a songwriting deal with Sony/ATV Music Publishing in 2004 and a recording contract with Big Machine Records in 2005. Her 2006 self-titled debut album made her the first female country singer to write or co-write a U.S. platinum-certified album entirely. Swift's next albums, '' Fearless'' (2008) and '' Speak Now'' (2010), explored country pop. The former's " Love Story" and "You Belong with Me" were the first country songs to top the U.S. pop and all-genre airplay charts, respectively. She experimented with rock and electronic styles on ''Red'' (2012), which featured her first ''Billboard'' Hot 100 number-one song, "We Are Neve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bill Gates
William Henry Gates III (born October 28, 1955) is an American business magnate and philanthropist. He is a co-founder of Microsoft, along with his late childhood friend Paul Allen. During his career at Microsoft, Gates held the positions of chairman, chief executive officer (CEO), President (corporate title), president and software architect, chief software architect, while also being the largest individual shareholder until May 2014. He was a major entrepreneur of the Home computer, microcomputer revolution of the 1970s and 1980s. Gates was born and raised in Seattle. In 1975, he and Allen founded Microsoft in Albuquerque, New Mexico. It became the world's largest personal computer software company. Gates led the company as chairman and CEO until stepping down as CEO in January 2000, succeeded by Steve Ballmer, but he remained chairman of the board of directors and became chief software architect. During the late 1990s, he was Criticism of Microsoft, criticized for his bu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George W
George Walker Bush (born July 6, 1946) is an American politician who served as the 43rd president of the United States from 2001 to 2009. A member of the Republican Party, Bush family, and son of the 41st president George H. W. Bush, he previously served as the 46th governor of Texas from 1995 to 2000. While in his twenties, Bush flew warplanes in the Texas Air National Guard. After graduating from Harvard Business School in 1975, he worked in the oil industry. In 1978, Bush unsuccessfully ran for the House of Representatives. He later co-owned the Texas Rangers of Major League Baseball before he was elected governor of Texas in 1994. As governor, Bush successfully sponsored legislation for tort reform, increased education funding, set higher standards for schools, and reformed the criminal justice system. He also helped make Texas the leading producer of wind powered electricity in the nation. In the 2000 presidential election, Bush defeated Democratic incum ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Social Security Disability Insurance
Social Security Disability Insurance (SSD or SSDI) is a payroll tax-funded federal insurance program of the United States government. It is managed by the Social Security Administration and designed to provide monthly benefits to people who have a medically determinable disability (physical or mental) that restricts their ability to be employed. SSDI does not provide partial or temporary benefits but rather pays only full benefits and only pays benefits in cases in which the disability is "expected to last at least one year or result in death." Relative to disability programs in other countries in the Organisation for Economic Co-operation and Development (OECD), the SSDI program in the United States has strict requirements regarding eligibility. People frequently confuse Social Security Disability Insurance (SSDI) and Supplemental Security Income (SSI). Unlike SSDI (as well as Social Security retirement benefits) where payment is based on contribution credits earned through pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amylyx Pharmaceuticals
Amylyx Pharmaceuticals, Inc is a biopharmaceutical company headquartered in Cambridge, Massachusetts. Amylyx is best known for AMX0035, an experimental therapy for amyotrophic lateral sclerosis. AMX0035 was approved for medical use in Canada as Albrioza, in June 2022, and in the United States, as Relyvrio, in September 2022. History Amylyx Pharmaceuticals was founded in 2013 by Joshua Cohen and Justin Klee when the two were undergraduate students at Brown University. The two proposed that taurursodiol and sodium phenylbutyrate together might prevent disfunction of mitochondria and the endoplasmic reticulum, safeguarding neurons. Klee and Cohen were advised by Rudolph E. Tanzi, who ultimately served as the founding chair of Amylyx's scientific advisory board. After Klee and Cohen were able to achieve strong results in pre clinical research, Tanzi connected the two to his colleagues at Massachusetts General Hospital, which culminated in clinical trials. The company was granted $ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AMX0035
Sodium phenylbutyrate/ursodoxicoltaurine, also known as sodium phenylbutyrate/taurursodiol and sold under the brand name Albrioza among others, is a fixed-dose combination medication used for the treatment of amyotrophic lateral sclerosis (ALS). It contains sodium phenylbutyrate and ursodoxicoltaurine (taurursodiol). The most common adverse reactions experienced with sodium phenylbutyrate/ursodoxicoltaurine include diarrhea, abdominal pain, nausea and upper respiratory tract infection. Sodium phenylbutyrate/ursodoxicoltaurine acts by blocking cell death pathways in mitochondria and in the endoplasmic reticulum. Sodium phenylbutyrate is a chemical chaperone that helps proteins maintain their normal conformation, preventing aggregation that may lead to cell death. Ursodoxicoltaurine improves mitochondrial energy production. The combination was approved for medical use in Canada as Albrioza, in June 2022, and in the United States, as Relyvrio, in September 2022. Medical uses ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New England Journal Of Medicine
''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. History In September 1811, John Collins Warren, a Boston physician, along with James Jackson, submitted a formal prospectus to establish the ''New England Journal of Medicine and Surgery and Collateral Branches of Science'' as a medical and philosophical journal. Subsequently, the first issue of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' was published in January 1812. The journal was published quarterly. In 1823, another publication, the ''Boston Medical Intelligencer'', appeared under the editorship of Jerome V. C. Smith. The editors of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' purchased the weekly ''Intelligencer'' for $600 in 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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