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ABT-724
ABT-724 is a drug which acts as a dopamine agonist, and is selective for the D4 subtype. It was developed as a possible drug for the treatment of erectile dysfunction, although poor oral bioavailability means alternative drugs such as ABT-670 may be more likely to be developed commercially. Nonetheless, it continues to be used in scientific research into the function of the D4 receptor. See also * ABT-670 * Bremelanotide * Cabergoline * Flibanserin * Intrinsa * Melanotan II * Pramipexole * PF-219,061 * Tibolone Tibolone, sold under the brand name Livial among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis. The medication is available alone and is not formulated ... * UK-414,495 References Dopamine agonists Piperazines 2-Pyridyl compounds Benzimidazoles {{genito-urinary-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dopamine Receptor D4
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5. The structure of DRD4 was recently reported in complex with the antipsychotic drug nemonapride. As with other dopamine receptor subtypes, the D4 receptor is activated by the neurotransmitter dopamine. It is linked to many neurological and psychiatric conditions including schizophrenia and bipolar disorder, ADHD, addictive behaviors, Parkinson's disease, and eating disorders such as anorexia nervosa. A weak association has been drawn between DRD4 and borderline personality disorder. It is also a target for drugs which treat schizophrenia and Parkinson's disease. The D4 receptor is considered to be D2-like in which the activated receptor inhibits the enzyme adenylate cyclase, thereby reducing the intracellular concentration of the second messenger cyclic AMP. Genetics The human protein is coded by the ''DRD4'' on chromosome 11 located in 11p15.5 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PF-219,061
PF-219,061 is a drug that was under drug development, development by Pfizer which acts as a potent and highly functional_selectivity, selective agonist for the dopamine D3_receptor, D3 Receptor (biochemistry), receptor. It was under development as a potential medication for the treatment of female sexual dysfunction. It did not advance into clinical trials. See also * ABT-670 * ABT-724 * Cabergoline * Bremelanotide * Flibanserin * Intrinsa * Melanotan II * OSU-6162 * PF-592,379 * Pramipexole * Tibolone * UK-414,495 References {{Dopaminergics Dopamine agonists Female sexual dysfunction drugs Phenylmorpholines Phenols Pfizer brands Abandoned drugs Aphrodisiacs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UK-414,495
UK-414,495 is a drug developed by Pfizer for the treatment of female sexual arousal disorder. UK-414,495 acts as a potent, selective inhibitor of the enzyme neutral endopeptidase, which normally serves to break down the neuropeptide VIP. The consequent increase in VIP activity alters blood flow to the genital region leading to increased lubrication and muscle relaxation. See also * ABT-670 * ABT-724 * Bremelanotide * Cabergoline * Flibanserin * Testosterone (patch) * Melanotan II * Pramipexole * PF-219,061 * S-17092 * Tibolone Tibolone, sold under the brand name Livial among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis. The medication is available alone and is not formulated ... References Hydrolase inhibitors Female sexual dysfunction drugs Thiadiazoles Carboxamides Carboxylic acids Aphrodisiacs Cyclopentanes Pfizer brands {{genito-urinary-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dopamine Agonist
A dopamine agonist (DA) is a compound that activates dopamine receptors. There are two families of dopamine receptors, D2-like and D1-like, and they are all G protein-coupled receptors. D1- and D5-receptors belong to the D1-like family and the D2-like family includes D2, D3 and D4 receptors. Dopamine agonists are primarily used to treat Parkinson's disease. They are also used, to a far lesser extent, in treating hyperprolactinemia and restless legs syndrome. They are not intended for treatment of clinical depression, and studies have shown severe detrimental side effects resulting from off-label use of dopamine agonists in treating depression, particularly in their tendency to produce impulse control disorders and extreme cases of withdrawal syndrome. Medical uses Parkinson's disease Dopamine agonists are mainly used in the treatment of Parkinson's disease. The cause of Parkinson's is not fully known but genetic factors, for example specific genetic mutations, and environmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erectile Dysfunction
Erectile dysfunction (ED), also called impotence, is the type of sexual dysfunction in which the penis fails to become or stay erect during sexual activity. It is the most common sexual problem in men.Cunningham GR, Rosen RC. Overview of male sexual dysfunction. In: UpToDate, Martin KA (Ed), UpToDate, Waltham, MA, 2018. Through its connection to self-image and to problems in sexual relationships, erectile dysfunction can cause psychological harm. In about 80% of cases, physical causes can be identified. These include cardiovascular disease; diabetes mellitus; neurological problems, such as those following prostatectomy; hypogonadism; and drug side effects. About 10% of cases are psychological impotence, caused by thoughts or feelings; here, there is a strong response to placebo treatment. The term ''erectile dysfunction'' is not used for other disorders of erection, such as priapism. Treatment involves addressing the underlying causes, lifestyle modifications, and addres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bremelanotide
Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women. Specifically it is used for low sexual desire which occurs before menopause and is not due to medical problems, psychiatric problems, or problems within the relationship. It is given by an injection just under the skin of the thigh or abdomen. Common side effects include nausea, pain at the site of injection, and headache. It may also cause a temporary increase in blood pressure and decrease in heart rate after each dose, and darkening of the gums, face, and breasts. The medication is a peptide and acts by activating the melanocortin receptors. Bremelanotide was approved for medical use in the United States in 2019. It was developed by Palatin Technologies. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. Medical uses Bremelanotide is used for the treatment of generalized hypoactive sexual desire disorder (HSDD) in premenopa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cabergoline
Cabergoline, sold under the brand name Dostinex among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson's disease, and for other indications. It is taken by mouth. Cabergoline is an ergot derivative and a potent dopamine D2 receptor agonist. Cabergoline was patented in 1980 and approved for medical use in 1993. Medical uses * Lactation suppression * HyperprolactinemiaUK electronic Medicines CompendiuDostinex TabletsLast Updated on eMC Dec 23, 2013 * Adjunctive therapy of prolactin-producing pituitary gland tumors (prolactinomas); * Monotherapy of Parkinson's disease in the early phase; * Combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson's disease; * In some countries also: ablactation and dysfunctions associated with hyperprolactinemia (amenorrhea, oligomenorrhea, anovulation, nonpuerperal mastitis and galactorrhea); * Treatment of uterine fib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flibanserin
Flibanserin, sold under the brand name Addyi, is a medication approved for the treatment of pre-menopausal women with hypoactive sexual desire disorder (HSDD). The medication improves sexual desire, increases the number of satisfying sexual events, and decreases the distress associated with low sexual desire. The most common side effects are dizziness, sleepiness, nausea, difficulty falling asleep or staying asleep and dry mouth. Development by Boehringer Ingelheim was halted in October 2010, following a negative evaluation by the US Food and Drug Administration (FDA).Spiegel onlinePharmakonzern stoppt Lustpille für die Frau 8 October 2010 (in German) The rights to the drug were then transferred to Sprout Pharmaceuticals, which achieved approval of the drug by the US FDA in August 2015. Addyi is approved for medical use in the US for premenopausal women with HSDD and in Canada for premenopausal and postmenopausal women with HSDD. HSDD was recognized as a distinct sexual func ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intrinsa
The testosterone patch, brand name Intrinsa among others, was designed to treat female sexual dysfunction. Mechanism of action Testosterone patches works by releasing the hormone testosterone through the skin into the bloodstream. In women, testosterone is naturally produced by the ovaries and the adrenal gland. However, levels of the hormone decline with age, sometimes more after menopause. Testosterone therapy is systemic and needs to be applied over a period of weeks or months to have an effect.Can Intrinsa Be a Viagra for Women? BusinessWeek, October 28, 2004. Retrieved June 22, 2007. P&G licensed the treatment to Watson Pharmaceuticals. Approval The patch was granted a license from the[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Melanotan II
Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal. It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased. Unlicensed, untested, or fraudulent products sold as "melanotan II" are found on the Internet, and purported to be effective as "tanning drugs", though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Mechanism of action Melanotan II acts as a non-selective agonist of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pramipexole
Pramipexole, sold under the brand Mirapex among others, is medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS). In Parkinson's disease it may be used alone or together with levodopa. It is taken by mouth. Pramipexole is a dopamine agonist of the non-ergoline class. Studies have shown detrimental side effects resulting from off-label use of pramipexole or other dopamine agonists in treating clinical depression. Pramipexole was approved for medical use in the United States in 1997. Use in pregnancy and breastfeeding is of unclear safety. It is available as a generic medication. In 2020, it was the 193rd most commonly prescribed medication in the United States, with more than 2million prescriptions. Medical uses Pramipexole is used in the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS). Use in pregnancy and breastfeeding is of unclear safety. It is occasionally prescribed off-label for depression. Its effectiveness as an an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
