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Antiprion Drug
Antiprion drugs are drugs that work against prions Prions are misfolded proteins that have the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It i .... The discovery of antiprion drugs is a priority because prion diseases are untreatable and fatal. Therefore, it is a therapeutic priority to find effective anti-prion drugs. __TOC__ Mechanism of action The disease progression in prion diseases is probably due to the conformational change of the prion protein (PrP). PrP changes from alpha-helical conformation to a disease-associated, mainly beta-sheeted scrapie isoform (PrPSc), which forms amyloid aggregates. The drugs that contain N′-benzylidene-benzohydrazide core structure are likely to slow down this progression. Drugs that target PrPC, the normal prion isoform, are also hypothesized to delay the progression of prion diseases. Ref ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prions
Prions are misfolded proteins that have the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It is not known what causes a normal protein to misfold, but the resulting abnormal three-dimensional structure confers infectious properties by collapsing nearby protein molecules into the same shape. The word ''prion'' is derived from the term, "proteinaceous infectious particle". In comparison to all other known infectious agents such as viroids, viruses, bacteria, fungi, and parasites, all of which contain nucleic acids ( DNA, RNA, or both), the hypothesized role of a protein as an infectious agent stands in contrast. Prion isoforms of the prion protein (PrP), whose specific function is uncertain, are hypothesized as the cause of transmissible spongiform encephalopathies (TSEs), including scrapie in sheep, chronic wasting disease (C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
