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Anopheles Darlingi
''Anopheles darlingi'', the American malaria mosquito, is a species of mosquito in the family Culicidae. ''A. darlingi'' is one of the major species of mosquito known to be responsible for malaria in the Amazonian regions. It has a wide range of geographic distribution that stretches from Mexico and Argentina but it has also been found to populate in areas affected by deforestation and environment changes due to humans. Breeding The breeding patterns of ''A. darlingi'' are affected heavily by the precipitation seen in their environment. Due to the fact that mosquitoes rely on the surfaces of stagnant water or areas with regular flooding as breeding grounds for their eggs and larvae, the annual density of the ''A. darlingi'' population is dependent upon the availability of larval habitats. During the wet season, riverine areas are often abundant with mosquitoes and densities are higher in these after the peak of rainfall. Oppositely, in drier inland areas that are usually further ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Culicidae
Mosquitoes (or mosquitos) are members of a group of almost 3,600 species of small flies within the family Culicidae (from the Latin ''culex'' meaning "gnat"). The word "mosquito" (formed by ''mosca'' and diminutive ''-ito'') is Spanish for "little fly". Mosquitoes have a slender segmented body, one pair of wings, one pair of halteres, three pairs of long hair-like legs, and elongated mouthparts. The mosquito life cycle consists of egg, larva, pupa, and adult stages. Eggs are laid on the water surface; they hatch into motile larvae that feed on aquatic algae and organic material. These larvae are important food sources for many freshwater animals, such as dragonfly nymphs, many fish, and some birds such as ducks. The adult females of most species have tube-like mouthparts (called a proboscis) that can pierce the skin of a host and feed on blood, which contains protein and iron needed to produce eggs. Thousands of mosquito species feed on the blood of various hosts — v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annual Reviews (publisher)
Annual Reviews is an independent, non-profit academic publishing company based in San Mateo, California. As of 2021, it publishes 51 journals of review articles and ''Knowable Magazine'', covering the fields of life, biomedical, physical, and social sciences. Review articles are usually “peer-invited” solicited submissions, often planned one to two years in advance, which go through a peer-review process. The organizational structure has three levels: a volunteer board of directors, editorial committees of experts for each journal, and paid employees. Annual Reviews' stated mission is to synthesize and integrate knowledge "for the progress of science and the benefit of society". The first Annual Reviews journal, the ''Annual Review of Biochemistry'', was published in 1932 under the editorship of Stanford University chemist J. Murray Luck, who wanted to create a resource that provided critical reviews on contemporary research. The second journal was added in 1939. By ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anopheles
''Anopheles'' () is a genus of mosquito first described and named by J. W. Meigen in 1818. About 460 species are recognised; while over 100 can transmit human malaria, only 30–40 commonly transmit parasites of the genus ''Plasmodium'', which cause malaria in humans in endemic areas. '' Anopheles gambiae'' is one of the best known, because of its predominant role in the transmission of the most dangerous malaria parasite species (to humans) – '' Plasmodium falciparum''. The name comes from the Ancient Greek word 'useless', derived from , 'not', 'un-' and 'profit'. Mosquitoes in other genera (''Aedes'', ''Culex'', '' Culiseta'', '' Haemagogus'', and ''Ochlerotatus'') can also serve as vectors of disease agents, but not human malaria. Evolution The ancestors of ''Drosophila'' and the mosquitoes diverged . The culicine and ''Anopheles'' clades of mosquitoes diverged between and . The Old and New World ''Anopheles'' species subsequently diverged between and . '' Anophel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
P450
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that functions as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In 1963, Estabrook, Cooper, and Rosenthal described the role of CYP as a catalyst in steroid hormone synthesis and drug metabolism. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones. CYP enzymes have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, and archaea, as well as in viruses. However, they are not omnipresent; for example, they have not been found in ''Escherichia coli''. , more than 300,000 distinct CYP proteins are known. CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glutathione S-transferase
Glutathione ''S''-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies: the cytosolic, mitochondrial, and microsomal—also known as MAPEG—proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new GST functions. GSTs can constitute up to 10% of cytosolic protein in some mammalian organs. GSTs catalyse the conjugation of GSH—via a sulfhydryl group—to electrophilic centers on a wide variety of substrates in order to make the compounds more water-soluble. This activity detoxifies endogenous co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Esterase
An esterase is a hydrolase enzyme that splits esters into an acid and an alcohol in a chemical reaction with water called hydrolysis. A wide range of different esterases exist that differ in their substrate specificity, their protein structure, and their biological function. EC classification/list of enzymes * ''EC 3.1.1'': Carboxylic ester hydrolases ** Acetylesterase (EC 3.1.1.6), splits off acetyl groups *** Cholinesterase **** Acetylcholinesterase, inactivates the neurotransmitter acetylcholine **** Pseudocholinesterase, broad substrate specificity, found in the blood plasma and in the liver ** Pectinesterase (EC 3.1.1.11), clarifies fruit juices * ''EC 3.1.2'': Thiolester hydrolases ** Thioesterase *** Ubiquitin carboxy-terminal hydrolase L1 * ''EC 3.1.3'': Phosphoric monoester hydrolases ** Phosphatase (EC 3.1.3.x), hydrolyses phosphoric acid monoesters into a phosphate ion and an alcohol *** Alkaline phosphatase, removes phosphate groups from many types of molecules, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insecticide Resistance
Pesticide resistance describes the decreased susceptibility of a pest population to a pesticide that was previously effective at controlling the pest. Pest species evolve pesticide resistance via natural selection: the most resistant specimens survive and pass on their acquired heritable changes traits to their offspring.PBS (2001)Pesticide resistance Retrieved on September 15, 2007. If a pest has ''resistance'' then the pesticide lacks ''efficacy'' efficacy and resistance are inversely related. Cases of resistance have been reported in all classes of pests (''i.e.'' crop diseases, weeds, rodents, ''etc.''), with 'crises' in insect control occurring early-on after the introduction of pesticide use in the 20th century. The Insecticide Resistance Action Committee (IRAC) definition of insecticide resistance is ''a heritable change in the sensitivity of a pest population that is reflected in the repeated failure of a product to achieve the expected level of control when used accordi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Whole Genome Sequence
Whole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014. In the future of personalized medicine, whole genome sequence data may be an important tool to guide therapeutic intervention. The tool of gene sequencing at SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response. Whole genome sequencing should not be confused with DNA profilin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annual Review Of Entomology
The ''Annual Review of Entomology'' is a peer-reviewed academic journal that publishes review articles about entomology, the study of insects. First published in 1956 from a collaboration between the Entomological Society of America and Annual Reviews, its longest-serving editors are Thomas E. Mittler (1967–1997) and May Berenbaum (1998–2018). As of 2022, it has a 2021 impact factor of 22.682. History In 1953, a committee within the Entomological Society of America examined the volume of literature published each year in the field and recommended that a journal be established that published review articles. The Entomological Society approached the nonprofit publisher Annual Reviews, which also agreed that there was a need for a review series in entomology. The ''Annual Review of Entomology'' published its first volume in 1956, making it the tenth title published by Annual Reviews. At first, the ESA remained involved with the operation of the journal and confirmed the e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. Symptoms usually begin ten to fifteen days after being bitten by an infected mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria. Malaria is caused by single-celled microorganisms of the ''Plasmodium'' group. It is spread exclusively through bites of infected ''Anopheles'' mosquitoes. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver where they mature and reproduce. Five species of ''Plasmodium'' can infect and be spread by h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fish Pond
A fish pond or fishpond is a controlled pond, small artificial lake or retention basin that is stocked with fish and is used in aquaculture for fish farming, for recreational fishing, or for ornamental purposes. Fish ponds are a classical garden feature in East Asian residence, such as the Classical Gardens of Suzhou of China, the Imperial Palace of Japan and the Gyeongbokgung Palace of South Korea. In Medieval Europe, it was also typical for monasteries and castles (small, partly self-sufficient communities) to have a fish pond. History Records of the use of fish ponds can be found from the early Middle Ages. "The idealized eighth-century estate of Charlemagne's capitulary ''de villis'' was to have artificial fishponds but two hundred years later, facilities for raising fish remained very rare, even on monastic estates.". As the Middle Ages progressed, fish ponds became a more common feature of urbanizing environments. Those with access to fish ponds had a controlled ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iquitos
Iquitos (; ) is the capital city of Peru's Maynas Province and Loreto Region. It is the largest metropolis in the Peruvian Amazon, east of the Andes, as well as the ninth-most populous city of Peru. Iquitos is the largest city in the world that cannot be reached by road that isn't on an island, it is accessible only by river and air. It is known as the "capital of the Peruvian Amazon". The city is located in the Great Plains of the Amazon Basin, fed by the Amazon, Nanay, and Itaya rivers. Overall, it constitutes the Iquitos metropolitan area, a conurbation of 471,993 inhabitants consisting of four districts: Iquitos, Punchana, Belén, and San Juan Bautista. The area has long been inhabited by indigenous peoples. According to Spanish historical documents, Iquitos was established around 1757 as a Spanish Jesuit reduction on the banks of the Nanay River. The Jesuits gathered local Napeano (Yameo) and Iquito natives to live here, and they named it ''San Pablo de Napeanos'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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