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ATC Code N05
N05A Antipsychotics N05AA Phenothiazines with aliphatic side-chain :N05AA01 Chlorpromazine :N05AA02 Levomepromazine :N05AA03 Promazine :N05AA04 Acepromazine :N05AA05 Triflupromazine :N05AA06 Cyamemazine :N05AA07 Chlorproethazine N05AB Phenothiazines with piperazine structure :N05AB01 Dixyrazine :N05AB02 Fluphenazine :N05AB03 Perphenazine :N05AB04 Prochlorperazine :N05AB05 Thiopropazate :N05AB06 Trifluoperazine :N05AB07 Acetophenazine :N05AB08 Thioproperazine :N05AB09 Butaperazine :N05AB10 Perazine N05AC Phenothiazines with piperidine structure :N05AC01 Periciazine :N05AC02 Thioridazine :N05AC03 Mesoridazine :N05AC04 Pipotiazine N05AD Butyrophenone derivatives :N05AD01 Haloperidol :N05AD02 Trifluperidol :N05AD03 Melperone :N05AD04 Moperone :N05AD05 Pipamperone :N05AD06 Bromperidol :N05AD07 Benperidol :N05AD08 Droperidol :N05AD09 Fluanisone :N05AD10 Lumateperone :QN05AD90 Azaperone N05AE Indole derivatives :N05AE01 Oxypertine :N05AE02 Molindone :N05AE03 Sertindole :N05AE04 Zi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antipsychotic
Antipsychotics, also known as neuroleptics, are a class of Psychiatric medication, psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders. They are also the mainstay together with mood stabilizers in the treatment of bipolar disorder. Prior research has shown that use of any antipsychotic is associated with smaller brain tissue volumes, including white matter reduction and that this brain shrinkage is dose dependent and time dependent. A more recent controlled trial suggests that second generation antipsychotics combined with intensive psychosocial therapy may potentially prevent pallidal brain volume loss in first episode psychosis. The use of antipsychotics may result in many unwanted side effects such as Extrapyramidal symptoms, involuntary movement disorders, gynecomastia, impotence, weight gain and metabolic syndrome. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thioproperazine
Thioproperazine, sold under the brand name Majeptil, is a typical antipsychotic of the phenothiazine group which is used as a tranquilizer, antiemetic, sedative, and in the treatment of schizophrenia and manic phase of bipolar disorder. Majeptil is available in 10 mg tablets. Side effects Common * Extrapyramidal symptoms * Amenorrhea * Decreased sexual interest and/or function * Swelling of breasts and milk production in males and females * Difficulty sleeping * Constipation * Reduced amount of urine * Dizziness * Drowsiness * Dry mouth * Nausea * Headache * Weight changes Rare but potentially serious adverse effects * Agranulocytosis * Neuroleptic Malignant Syndrome (NMS) * Sudden cardiac death * Torsades de pointes Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics. Drug interactions Medications for allergies (e.g., Benadryl diphenhydramine) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pipamperone
Pipamperone ( INN, USAN, BAN), also known as carpiperone and floropipamide or fluoropipamide, and as floropipamide hydrochloride ( JAN), is a typical antipsychotic of the butyrophenone family used in the treatment of schizophrenia and as a sleep aid for depression. It is or has been marketed under brand names including Dipiperon, Dipiperal, Piperonil, Piperonyl, and Propitan. Pipamperone was discovered at Janssen Pharmaceutica in 1961, and entered clinical trials in the United States in 1963. Pharmacology Pipamperone acts as an antagonist of the 5-HT2A, 5-HT2B, 5-HT2C D2, D3, D4, α1-adrenergic, and α2-adrenergic receptors. It shows much higher affinity for the 5-HT2A and D4 receptors over the D2 receptor (15-fold in the case of the D4 receptor, and even higher in the case of the 5-HT2A receptor), being regarded as "highly selective" for the former two sites at low doses. Pipamperone has low and likely insignificant affinity for the H1 and mACh receptors, as well as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moperone
Moperone (Luvatren, since discontinued) is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia. It is an antagonist An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ... for the D2 (''Ki'' 0.7–1.9 nM), D3 (''Ki'' 0.1–1 nM), and 5-HT2A (''Ki'' 52 nM) receptors. It also has a high binding affinity for the sigma receptors. References Abandoned drugs Tertiary alcohols Butyrophenone antipsychotics Fluoroarenes 4-Phenylpiperidines Typical antipsychotics 4-Tolyl compounds {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Melperone
Melperone (Bunil ( PT), Buronil ( AT, BE, CZ, DK, FL†, NL†, NO†, SE), Eunerpan ( DE)) is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol. It first entered clinical use in 1960s. Marketing and indications It has been tried in treatment-resistant cases of schizophrenia with some (albeit limited) success. It has also been reported effective in the treatment of L-DOPA and other forms of psychosis in Parkinson's disease (although a multicentre, double-blind, placebo-controlled study conducted in 2012 failed to support these findings). It is also known to possess anxiolytic properties. It is marketed in the following countries: * Austria * Belgium * Czech Republic * Denmark * Estonia * Finland * Germany * Iceland * Lithuania * Latvia * Portugal * Sweden Adverse effects Melperone is reported to produce significantly less weight gain than clozapine and approximately as much weight gai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trifluperidol
Trifluperidol is a typical antipsychotic of the butyrophenone chemical class. It has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects. It is used in the treatment of psychoses including mania and schizophrenia. It was discovered at Janssen Pharmaceutica in 1959. Synthesis The Grignard reaction between 1-benzyl-4-piperidone 612-20-2(1) and 3-bromobenzotrifluoride 01-78-5(2) gives 1-benzyl-4-(3-(trifluoromethyl)phenyl)piperidin-4-olCID:12718203(3). Catalytic hydrogenation Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to reduce or saturate organic ... removes the benzyl protecting group to give 4- -(trifluoromethyl)phenyl4-piperidinol 249-28-7(4). Alkyl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haloperidol
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal. It may be used by mouth or injection into a muscle or a vein. Haloperidol typically works within 30 to 60 minutes. A long-acting formulation may be used as an injection every four weeks by people with schizophrenia or related illnesses, who either forget or refuse to take the medication by mouth. Haloperidol may result in a movement disorder known as tardive dyskinesia which may be permanent. Neuroleptic malignant syndrome and QT interval prolongation may occur. In older people with psychosis due to dementia it results in an increased risk of death. When taken during pregnancy it may result in problems in the infant. It should not be used by people with Parkinson's disease. Haloperidol was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Butyrophenone
Butyrophenone is an organic compound with the formula C6H5C(O)C3H7. It is a colorless liquid. The butyrophenone structure—a ketone flanked by a phenyl ring and a butyl chain—forms the basis for many other chemicals containing various substituents. Some of these butyrophenones are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics. Examples of butyrophenone-derived pharmaceuticals include: * Haloperidol, the most widely used classical antipsychotic drug in this class * Benperidol, the most potent commonly used antipsychotic (200 times more potent than chlorpromazine) * Droperidol, Antiemetic for postoperative nausea and vomiting Postoperative nausea and vomiting (PONV) is the phenomenon of nausea, vomiting, or retching experienced by a patient in the postanesthesia care unit (PACU) or within 24 hours following a surgical procedure. PONV affects about 10% of the population ... References Aromatic ketones Phenyl compou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pipotiazine
Pipotiazine (Piportil), also known as pipothiazine, is a typical antipsychotic of the phenothiazine class used in the United Kingdom and other countries for the treatment of schizophrenia. Its properties are similar to those of chlorpromazine. A 2004 systematic review investigated its efficacy for people with schizophrenia: Synthesis The alkylation of 2-Dimethylaminosulfonylphenthiazine 090-78-4(1) with 1-Bromo-3-chloropropane (2) gives 10-(3-chloropropyl)-N,N-dimethylphenothiazine-2-sulfonamide 0051-12-5(3). Alkylation with 4-Piperidineethanol 22-26-4 The hyphen-minus is the most commonly used type of hyphen, widely used in digital documents. It is the only character that looks like a minus sign or a dash in many character sets such as ASCII or on most keyboards, so it is also used as such. ...(4) completes the synthesis of ''Pipothiazine'' (5). See also * Typical antipsychotic * Phenothiazine References Phenothiazines Typical antipsychotics Piperazine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mesoridazine
Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. The drug's name is derived from the methylsulfoxy and piperidine functional groups in its chemical structure. It has central antiadrenergic, antidopaminergic, antiserotonergic and weak muscarinic anticholinergic effects. Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome Neuroleptic malignant syndrome (NMS) is a rare but life-threatening reaction that can occur in response to neuroleptic or antipsychotic medication. Symptoms include high fever, confusion, rigid muscles, variable blood pressure, sweating, and fa .... Mesoridazine was withdrawn from the United States market in 2004 due to dangerous side effects, namely irregular heart beat and QT-prolongation of the electrocardiogram. It currently appears to be unavailable wor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thioridazine
Thioridazine (Mellaril or Melleril) is a first generation antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. The branded product was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias. However, generic versions are still available in the US. Indications Thioridazine was voluntarily discontinued by its manufacturer, Novartis, worldwide because it caused severe cardiac arrhythmias. Its primary use in medicine was the treatment of schizophrenia. It was also tried with some success as a treatment for various psychiatric symptoms seen in people with dementia, but chronic use of thioridazine and other anti-psychotics in people with dementia is not recommended. Side effects Thioridazine prolongs the QTc interval in a dose-dependent manner. It produces significantly less extrapyramidal side effects than most first-generation antipsychotics, likely due to its potent ant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Periciazine
Periciazine (INN), also known as pericyazine ( BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics. Periciazine is not approved for sale in the United States. It is commonly sold in Canada, Italy and Russia under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil. Medical uses The primary uses of periciazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia. There is insufficient evidence to determine whether periciazine is more or less effective than other antipsychotics. A 2014 systematic review compared periciazine with typical antipsychotics for schizophrenia: Periciazine has also been studied in the treatment of opioid dependence. Adverse effects Periciazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
