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AIDS Research
HIV/AIDS research includes all medical research that attempts to prevent, treat, or cure HIV/AIDS, as well as fundamental research about the nature of HIV as an infectious agent and AIDS as the disease caused by HIV. Transmission A body of scientific evidence has shown that men who are circumcised are less likely to contract HIV than men who are uncircumcised. Research published in 2014 concludes that the sex hormones estrogen and progesterone selectively impact HIV transmission. Pre- and post-exposure prophylaxis "Pre-exposure prophylaxis" refers to the practice of taking some drugs before being exposed to HIV infection, and having a decreased chance of contracting HIV as a result of taking that drug. Post-exposure prophylaxis refers to taking some drugs quickly after being exposed to HIV, while the virus is in a person's body but before the virus has established itself. In both cases, the drugs would be the same as those used to treat persons with HIV, and the intent of taki ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adenoviridae
Adenoviruses (members of the family (biology), family ''Adenoviridae'') are medium-sized (90–100 nanometer, nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. Their name derives from their initial isolation from human adenoids in 1953. They have a broad range of vertebrate hosts; in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of Adenovirus infection, illnesses, from mild respiratory infections in young children (the common cold) to life-threatening multi-organ disease in people with a Immunodeficiency, weakened immune system. Virology Classification This family contains the following genus, genera: * ''Aviadenovirus'' * ''Barthadenovirus'' * ''Ichtadenovirus'' * ''Mastadenovirus'' (including all human adenoviruses) * ''Siadenovirus'' * ''Testadenovirus'' Diversity In humans, currently there are 88 human adenoviruses (HAdVs) in seven species (H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Belfast Telegraph
The ''Belfast Telegraph'' is a daily newspaper published in Belfast, Northern Ireland, by Independent News & Media, which also publishes the Irish Independent, the Sunday Independent and various other newspapers and magazines in Ireland. Its editor is Eoin Brannigan. Reflecting its unionist tradition, the paper has historically been "favoured by the Protestant population", while also being read within Catholic nationalist communities in Northern Ireland. It has been owned by Independent News and Media, a Dublin-based media company, since 2000, and is the company's only print title outside of the Republic of Ireland. History It was first published as the ''Belfast Evening Telegraph'' on 1 September 1870 by brothers William and George Baird. Its first edition cost half a penny and ran to four pages covering the Franco-Prussian War and local news. The evening edition of the newspaper was originally called the "Sixth Late", and "Sixth Late Tele" was a familiar cry made by vendo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CRISPR
CRISPR (; acronym of clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. Each sequence within an individual prokaryotic CRISPR is derived from a DNA fragment of a bacteriophage that had previously infected the prokaryote or one of its ancestors. These sequences are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral (i.e. anti- phage) defense system of prokaryotes and provide a form of heritable, acquired immunity. CRISPR is found in approximately 50% of sequenced bacterial genomes and nearly 90% of sequenced archaea. Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and open up specific strands of DNA that are complementary to the CRISPR sequence. Cas9 enzymes together with CRISPR sequences form the basis of a technology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Excision BioTherapeutics
Excision BioTherapeutics is a biopharmaceutical company based in San Francisco focused on developing gene therapies against HIV infection. The company has a single, CRISPR–Cas9 based therapy, EBT-101, under investigation. Initial investigation into the therapy was conducted by the lab of Kamel Khalili, a professor at Temple University. In July 2023 the US Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ... granted EBT-101 fast-track status. In October 2023 an early-stage study on 3 people reported that the treatment appeared to be safe with no major side effects but no data on its effectiveness was disclosed. See also * CRISPR gene editing#HIV/AIDS References {{med-tech-company-stub Pharmaceutical companies of the United States Antiretrovir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Allergy And Infectious Diseases
The National Institute of Allergy and Infectious Diseases (NIAID, ) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services. NIAID's mission is to conduct Basic research, basic and applied research to better understand, treat, and prevent Infectious disease, infectious, Immune disorder, immunologic, and Allergy, allergic diseases. NIAID has on-campus Laboratory, laboratories in Maryland and Hamilton, Montana, and funds research conducted by scientists at institutions in the United States and throughout the world. NIAID also works closely with partners in academia, industry, government, and non-governmental organizations in multifaceted and multidisciplinary efforts to address emerging health challenges such as the Pandemic H1N1/09 virus, H1N1/09 pandemic and the COVID-19 pandemic. History NIAID traces its origins to a small laboratory established in 1887 at the Marine H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anthony Fauci
Anthony Stephen Fauci ( ; born December 24, 1940) is an American physician-scientist and immunologist who served as the director of the National Institute of Allergy and Infectious Diseases (NIAID) from 1984 to 2022, and the chief medical advisor to the president from 2021 to 2022. Fauci was one of the world's most frequently cited scientists across all scientific journals from 1983 to 2002. In 2008, President George W. Bush awarded him the Presidential Medal of Freedom, the highest civilian award in the United States, for his work on the AIDS relief program PEPFAR. Fauci received his undergraduate education at the College of the Holy Cross and his Doctor of Medicine from Cornell University. As a physician with the National Institutes of Health (NIH), Fauci served the American public health sector for more than fifty years and has acted as an advisor to every U.S. president since Ronald Reagan. During his time as director of the NIAID, he made contributions to HIV/AIDS re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Francis Collins
Francis Sellers Collins (born April 14, 1950) is an American physician-scientist who discovered the genes associated with a number of diseases and led the Human Genome Project. He served as director of the National Institutes of Health (NIH) in Bethesda, Maryland, from 17 August 2009 to 19 December 2021, serving under three presidents. Collins announced his retirement publicly from the NIH on March 1, 2025, after 32 years of service. Before being appointed director of the NIH, Collins led the Human Genome Project and other genomics research initiatives as director of the National Human Genome Research Institute (NHGRI), one of the 27 institutes and centers at NIH. Before joining NHGRI, he earned a reputation as a gene hunter at the University of Michigan. He has been elected to the Institute of Medicine and the National Academy of Sciences, and has received the Presidential Medal of Freedom and the National Medal of Science. Collins has written books on science, medicine, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bill & Melinda Gates Foundation
The Gates Foundation is an American private foundation founded by Bill Gates and Melinda French Gates. Based in Seattle, Washington, it was launched in 2000 and is reported to be the third largest charitable foundation in the world, holding $77.2 billion in assets as of December 31, 2024. The primary stated goals of the foundation are to enhance healthcare and reduce extreme poverty across the world, and to expand educational opportunities and access to information technology in the U.S. Key individuals of the foundation include Warren Buffett, chief executive officer Mark Suzman, and Michael Larson. The scale of the foundation and the way it seeks to apply business techniques to giving makes it one of the leaders in venture philanthropy, though the foundation itself notes that the philanthropic role has limitations. In 2007, its founders were ranked as the second most generous philanthropists in the U.S., behind Warren Buffett. Bill Gates and Melinda French Gates had dona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CXCR4
C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the ''CXCR4'' gene. The protein is a CXC chemokine receptor. Function CXCR-4 is an alpha- chemokine receptor specific for stromal-derived-factor-1 ( SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 is one of several chemokine co-receptors that HIV can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4-using HIV is a consequence or a cause of immunodeficiency. CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adam Castillejo
Adam Castillejo (born 1979 or 1980), also known as "The London Patient", is the second person known to have been cured of HIV infection. Castillejo, who is British-Venezuelan and has mixed European ancestry, lives in London. He has previously worked as a chef and is now a motivational speaker. Diagnosed in 2003, his body became resistant to HIV infection after receiving a bone marrow transplant in 2016 to treat Hodgkin's lymphoma. The German donor carried the CCR5-Δ32 mutation which gives resistance from HIV infection. It is likely because of his half-Dutch father that Adam’s donor was compatible with him. He was treated by Professor Ravindra Gupta. See also * Timothy Ray Brown * Stephen Crohn * Innate resistance to HIV * Long term nonprogressor * HIV/AIDS research HIV/AIDS research includes all medical research that attempts to prevent, treat, or cure HIV/AIDS, as well as fundamental research about the nature of HIV as an infectious agent and AIDS as the disease ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Timothy Ray Brown
Timothy Ray Brown (March 11, 1966September 29, 2020) was an American considered to be the first person cured of HIV/AIDS. Brown was called "The Berlin Patient" at the 2008 Conference on Retroviruses and Opportunistic Infections, where his cure was first announced, in order to preserve his anonymity. He chose to come forward in 2010. "I didn't want to be the only person cured," he said. "I wanted to do what I could to make curepossible. My first step was releasing my name and image to the public." Procedure Timothy Ray Brown was born in Seattle, Washington, on March 11, 1966, and raised in the area by his single mother, Sharon, who worked for the King County sheriff's department. He journeyed across Europe as a young adult and was diagnosed with HIV in 1995 while studying in Berlin. In 2006, he was diagnosed with acute myeloid leukemia. On February 7, 2007, he underwent a procedure known as hematopoietic stem cell transplantation to treat leukemia (performed by a team of doc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
