A.C.E. Mixture
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A.C.E. Mixture
ACE mixture is an historical anaesthetic agent for general anaesthesia. It was first suggested by George Harley and first used in England around 1860. In 1864 it was recommended for use by the Royal Medical and Surgical Society's Chloroform Committee. It was rarely used after the 19th century, except in Germany, where it was used for slightly longer. It was a mixture of alcohol, chloroform and ether which gives the mixture its name. Its effects were said to be between that of chloroform and ether and it was used when ether alone was contraindicated. Its boiling point was given as °C. Its actual safety margin over its components alone was marginal. Usage ACE mixture was most commonly made up in the ratio: 1 part alcohol, 2 parts chloroform, and 3 parts ether although other ratios existed. See ' other preparations' below. Chloroform (which was first used in 1847) used on its own produces myocardial depression, however the excitatory properties of the alcohol and ether cont ...
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Anesthetic
An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia ⁠— ⁠in other words, to result in a temporary loss of sensation or awareness. They may be divided into two broad classes: general anesthetics, which result in a reversible loss of consciousness, and local anesthetics, which cause a reversible loss of sensation for a limited region of the body without necessarily affecting consciousness. A wide variety of drugs are used in modern anesthetic practice. Many are rarely used outside anesthesiology, but others are used commonly in various fields of healthcare. Combinations of anesthetics are sometimes used for their synergistic and additive therapeutic effects. Adverse effects, however, may also be increased. Anesthetics are distinct from analgesics, which block only sensation of painful stimuli. Local anesthetics Local anesthetic agents prevent the transmission of nerve impulses without causi ...
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Eau De Cologne
Eau de Cologne (; German: ''Kölnisch Wasser'' ; meaning "Water from Cologne"), or simply cologne, is a perfume originating from Cologne, Germany. Originally mixed by Johann Maria Farina (Giovanni Maria Farina) in 1709, it has since come to be a generic term for scented formulations in typical concentration of 2–5% and also more depending upon its type of essential oils or a blend of extracts, alcohol, and water. In a base of dilute ethanol (70–90%), eau de cologne contains a mixture of citrus oils, including oils of lemon, orange, tangerine, clementine, bergamot, lime, grapefruit, blood orange, bitter orange, and neroli. It can also contain oils of lavender, rosemary, thyme, oregano, petitgrain (orange leaf), jasmine, olive, oleaster, and tobacco. In contemporary American English usage, the term "cologne" has become a generic term for perfumes marketed toward men. It also may signify a less concentrated, more affordable, version of a popular perfume. History The original ' ...
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General Anesthetics
General anaesthetics (or anesthetics, see spelling differences) are often defined as compounds that induce a loss of consciousness in humans or loss of righting reflex in animals. Clinical definitions are also extended to include an induced coma that causes lack of awareness to painful stimuli, sufficient to facilitate surgical applications in clinical and veterinary practice. General anaesthetics do not act as analgesics and should also not be confused with sedatives. General anaesthetics are a structurally diverse group of compounds whose mechanisms encompasses multiple biological targets involved in the control of neuronal pathways. The precise workings are the subject of some debate and ongoing research. General anesthetics elicit a state of general anesthesia. It remains somewhat controversial regarding how this state should be defined. General anesthetics, however, typically elicit several key reversible effects: immobility, analgesia, amnesia, unconsciousness, and reduced a ...
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Anesthesia
Anesthesia is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes. It may include some or all of analgesia (relief from or prevention of pain), paralysis (muscle relaxation), amnesia (loss of memory), and unconsciousness. An individual under the effects of anesthetic drugs is referred to as being anesthetized. Anesthesia enables the painless performance of procedures that would otherwise cause severe or intolerable pain in a non-anesthetized individual, or would otherwise be technically unfeasible. Three broad categories of anesthesia exist: * General anesthesia suppresses central nervous system activity and results in unconsciousness and total lack of sensation, using either injected or inhaled drugs. * Sedation suppresses the central nervous system to a lesser degree, inhibiting both anxiety and creation of long-term memories without resulting in unconsciousness. * Regional and local anesthesia, which blo ...
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Flickr
Flickr ( ; ) is an American image hosting and video hosting service, as well as an online community, founded in Canada and headquartered in the United States. It was created by Ludicorp in 2004 and was a popular way for amateur and professional photographers to host high-resolution photos. It has changed ownership several times and has been owned by SmugMug since April 20, 2018. Flickr had a total of 112 million registered members and more than 3.5 million new images uploaded daily. On August 5, 2011, the site reported that it was hosting more than 6 billion images. Photos and videos can be accessed from Flickr without the need to register an account, but an account must be made to upload content to the site. Registering an account also allows users to create a profile page containing photos and videos that the user has uploaded and also grants the ability to add another Flickr user as a contact. For mobile users, Flickr has official mobile apps for iOS, Android, and an op ...
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James Tayloe Gwathmey
James Tayloe Gwathmey, M.D. (September 10, 1862—February 11, 1944) was an American physician and the first president of the American Association of Anesthetics (now the International Anesthesia Research Society). A pioneer of early anesthetic devices for medical use, he co-authored the first comprehensive textbook on the subject of medical anesthetics, titled ''Anesthesia'', which was published in 1914. For this and other contributions to anesthesiology, which included innovations in administering anesthetics to war wounded and in obstetrics, Gwathmey was hailed at the time of his death as the "Father of Modern Anesthesia." Biography Early life Gwathmey was born on September 10, 1862, at Buena Vista in Roanoke, Virginia, the childhood home of his mother, Mary Lavinia Tayloe, daughter of George Plater Tayloe and Mary Elizabeth Langhorne. He was a student at the Norfolk Male Academy and later attended the Virginia Military Institute. The third year of his college education wa ...
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Clover's Inhaler
Joseph Thomas Clover (28 February 1825; baptised 7 May 1825 – 27 September 1882) was an English doctor and pioneer of anaesthesia. He invented a variety of pieces of apparatus to deliver anaesthetics including ether and chloroform safely and controllably. By 1871 he had administered anaesthetics 13,000 times without a fatality. Clover assisted at surgery of public figures including Napoleon III, Princess Alexandra of Denmark and her husband King Edward VII (then Prince of Wales), Sir Robert Peel, and Florence Nightingale. His inventions included the bulky 'Clover's chloroform apparatus' (1862), with which he was often photographed; and the compact 'Clover's portable regulating ether inhaler' (1877), which remained in use well into the 20th century. With fellow pioneer John Snow, Clover is one of the supporters on the crest of the Royal College of Anaesthetists. Early life Clover was born in the town of Aylsham, Norfolk Rushman, page 27. to John Wright Clover, a draper a ...
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Towel
A towel is a piece of absorbent cloth or paper used for drying or wiping a surface. Towels draw moisture through direct contact. In households, several types of towels are used, such as hand towels, bath towels, and kitchen towels. Paper towels are provided in commercial or office bathrooms via a dispenser for users to dry their hands. They are also used for such duties such as wiping, cleaning, and drying. History According to Middle Ages archaeological studies, "... closely held personal items included the ever present knife and a towel." However, the invention of the towel is commonly associated with the city of Bursa, Turkey, in the 17th century. These Turkish towels began as a flat, woven piece of cotton or linen called a ''peshtamal'', often hand-embroidered. Long enough to wrap around the body, peshtamal were originally fairly narrow, but are now wider and commonly measure . Pestamel were used in Turkish baths as they stayed light when wet and were very absorbent. As t ...
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Vivisection
Vivisection () is surgery conducted for experimental purposes on a living organism, typically animals with a central nervous system, to view living internal structure. The word is, more broadly, used as a pejorative catch-all term for experimentation on live animalsTansey, E.MReview of ''Vivisection in Historical Perspective by Nicholaas A. Rupke, book reviews, National Center for Biotechnology Information, p. 226. by organizations opposed to animal experimentation,Yarri, Donna''The Ethics of Animal Experimentation: A Critical Analysis and Constructive Christian Proposal, Oxford University Press, 2005, p. 163. but the term is rarely used by practising scientists. Human vivisection, such as live organ harvesting, has been perpetrated as a form of torture. Animal vivisection Research requiring vivisection techniques that cannot be met through other means is often subject to an external ethics review in conception and implementation, and in many jurisdictions use of anesthesia is ...
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Carl Ludwig Schleich
Carl Ludwig Schleich (19 July 1859 – 7 March 1922) was a German surgeon and writer. He is best known for his contribution to clinical anesthesia. In addition, he was also a philosopher, poet and painter. Biography Family Schelich's ancestors were a Munich family of prominent painters who had moved to Freienwalde. They included Robert Schleich and Eduard Schleich the Elder. Early life From a very early age, Schleich was exposed to a background in biology. His father was very interested in natural history and the leading theories in the epoch. Later Schleich would recall: In the year 1864, Graefe was a guest in my father's house during the historic conference of biologists, at which Darwin, Haeckel, and Virchow were the mutually hostile protagonists. I, alas, who was only five years of age, was not even aware of this earth-shaking event, since I was lying unconscious in the grip of meningitis. In his childhood, he frequently heard "extremely vigorous" debates about th ...
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Petroleum Ether
Petroleum ether is the petroleum fraction consisting of aliphatic hydrocarbons and boiling in the range 35–60 °C, and commonly used as a laboratory solvent. Despite the name, petroleum ether is not classified as an ether; the term is used only figuratively, signifying extreme lightness and volatility. Properties The very lightest, most volatile liquid hydrocarbon solvents that can be bought from laboratory chemical suppliers may also be offered under the name petroleum ether. Petroleum ether consists mainly of aliphatic hydrocarbons and is usually low on aromatics. It is commonly hydrodesulfurized and may be hydrogenated to reduce the amount of aromatic and other unsaturated hydrocarbons. Petroleum ether bears normally a descriptive suffix giving the boiling range. Thus, from the leading international laboratory chemical suppliers it is possible to buy various petroleum ethers with boiling ranges such as 30–50 °C, 40–60 °C, 50–70 °C, 60–80&nbs ...
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Methanol
Methanol (also called methyl alcohol and wood spirit, amongst other names) is an organic chemical and the simplest aliphatic alcohol, with the formula C H3 O H (a methyl group linked to a hydroxyl group, often abbreviated as MeOH). It is a light, volatile, colourless, flammable liquid with a distinctive alcoholic odour similar to that of ethanol (potable alcohol). A polar solvent, methanol acquired the name wood alcohol because it was once produced chiefly by the destructive distillation of wood. Today, methanol is mainly produced industrially by hydrogenation of carbon monoxide. Methanol consists of a methyl group linked to a polar hydroxyl group. With more than 20 million tons produced annually, it is used as a precursor to other commodity chemicals, including formaldehyde, acetic acid, methyl tert-butyl ether, methyl benzoate, anisole, peroxyacids, as well as a host of more specialised chemicals. Occurrence Small amounts of methanol are present in normal, healthy hu ...
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