|
3-methylglutaconic Acid
3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria or 3-hydroxy-3-methylglutaric aciduria. See also * Glutaconic acid ''trans''-Glutaconic acid is an organic compound with formula HO2CCH=CHCH2CO2H. This dicarboxylic acid exists as a colorless solid and is related to the saturated chemical glutaric acid, HO2CC(CH2)3CO2H. Esters and salts of glutaconic acid are ... References * External links 2TMS Spectrum {{DEFAULTSORT:Methylglutaconic acid, 3- Dicarboxylic acids ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-Methylglutaconic Aciduria
3-Methylglutaconic aciduria (MGA) is any of at least five metabolic disorders that impair the body's ability to make energy in the mitochondria. As a result of this impairment, 3-methylglutaconic acid and 3-methylglutaric acid build up and can be detected in the urine. 3-Methylglutaconic acid is an organic acid. The double carboxylic acid functions are the principal cause of the strength of this acid. 3-methylglutaconic acid can be detected by the presence of the acid function and the double connection that involves reactivity with some specific substances. Genetics The inheritance patterns of 3-methylglutaconic aciduria differ depending on the gene involved. * Types I and III are inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered. Most often, the parents of an individual with an autosomal recessive disorder are carriers of one copy of the altered gene but do not show signs and symptoms of the disorder. * Type II is inherite ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glutaconic Acid
''trans''-Glutaconic acid is an organic compound with formula HO2CCH=CHCH2CO2H. This dicarboxylic acid exists as a colorless solid and is related to the saturated chemical glutaric acid, HO2CC(CH2)3CO2H. Esters and salts of glutaconic acid are called glutaconates. Related compounds The geometric isomer, ''cis''-glutaconic acid, has a noticeably lower melting point (130–132 °C). It can be prepared by bromination of levulinic acid followed by treatment of the dibromoketone with potassium carbonate. Glutaconic anhydride, which forms by dehydration the diacid, exists mainly as the dicarbonyl tautomer in solution. It is a colorless solid melting at 77–82 °C. Either the ''cis'' or ''trans'' diacid can be used to make it: the ''trans'' form isomerizes under the reaction conditions.{{cite journal , author1=Briggs, S. P., author2=Davies, D. I., author3=Newton, R. F., author4=Reynolds, D. P. , title= The Structure of Glutaconic Anhydride and the Synthetic Utility of its Die ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |