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3-Bromopyridine
3-Bromopyridine is an organohalide with the formula C5H4BrN. It is a colorless liquid that is mainly used as a building block in organic synthesis. It participates as a substrate in many reactions associated with aryl halides, e.g., the Heck reaction The Heck reaction (also called the Mizoroki–Heck reaction) is the chemical reaction of an unsaturated halide (or triflate) with an alkene in the presence of a base and a palladium catalyst (or palladium nanomaterial-based catalyst) to form a s ... and Buchwald-Hartwig coupling. Related compounds * 3-Chloropyridine * 2-Bromopyridine References 3-Pyridyl compounds Bromoarenes {{DEFAULTSORT:Bromopyridine, 3- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-Chloropyridine
3-Chloropyridine is an organohalide with the formula C5H4ClN. It is a colorless liquid that is mainly used as a building block in organic synthesis. The compound is a substrate for many coupling processes including the Heck reaction, Suzuki reaction, and Ullmann reaction The Ullmann reaction or Ullmann coupling is a coupling reaction between aryl halides. Traditionally this reaction is effected by copper, but palladium and nickel are also effective catalysts. The reaction is named after Fritz Ullmann. Mechanism .... Related compounds * 3-Bromopyridine * 2-Chloropyridine References {{DEFAULTSORT:Chloropyridine, 3- Chloropyridines 3-Pyridyl compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organohalide
Halocarbon compounds are chemicals in which one or more carbon atoms are linked by covalent bonds with one or more halogen atoms (fluorine, chlorine, bromine or iodine – ) resulting in the formation of organofluorine compounds, organochlorine compounds, organobromine compounds, and organoiodine compounds. Chlorine halocarbons are the most common and are called organochlorides. Many synthetic organic compounds such as plastic polymers, and a few natural ones, contain halogen atoms; they are known as ''halogenated'' compounds or ''organohalogens''. Organochlorides are the most common industrially used organohalides, although the other organohalides are used commonly in organic synthesis. Except for extremely rare cases, organohalides are not produced biologically, but many pharmaceuticals are organohalides. Notably, many pharmaceuticals such as Prozac have trifluoromethyl groups. For information on inorganic halide chemistry, see halide. Chemical families Halocarbons are t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heck Reaction
The Heck reaction (also called the Mizoroki–Heck reaction) is the chemical reaction of an unsaturated halide (or triflate) with an alkene in the presence of a base and a palladium catalyst (or palladium nanomaterial-based catalyst) to form a substituted alkene. It is named after Tsutomu Mizoroki and Richard F. Heck. Heck was awarded the 2010 Nobel Prize in Chemistry, which he shared with Ei-ichi Negishi and Akira Suzuki, for the discovery and development of this reaction. This reaction was the first example of a carbon-carbon bond-forming reaction that followed a Pd(0)/Pd(II) catalytic cycle, the same catalytic cycle that is seen in other Pd(0)-catalyzed cross-coupling reactions. The Heck reaction is a way to substitute alkenes. History The original reaction by Tsutomu Mizoroki (1971) describes the coupling between iodobenzene and styrene in methanol to form stilbene at 120 °C (autoclave) with potassium acetate base and palladium chloride catalysis. This work was an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
