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2003 Midwest Monkeypox Outbreak
Beginning in May 2003, by July a total of 71 cases of human monkeypox were found in six Midwestern states including Wisconsin (39 cases), Indiana (16), Illinois (12), Kansas (1), Missouri (2), and Ohio (1). The cause of the outbreak was traced to three species of African rodents (Gambian pouched rat, dormice, rope squirrels) imported from Ghana on April 9, 2003, into the United States by an exotic animal importer in Texas. These were shipped from Texas to an Illinois distributor, who housed them with prairie dogs, which then became infected. The outbreak marked the first time monkeypox infection appeared in the United States, and the first time in the Western Hemisphere. No deaths were reported, and no human-to-human transmission was found. All cases involved direct contact with infected prairie dogs. Electron microscopy and testing by polymerase chain reaction and immunohistochemistry were used to confirm the causative agent was human monkeypox.Centers for Disease Control ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monkeypox
Monkeypox (also called mpox by the WHO) is an infectious viral disease that can occur in humans and some other animals. Symptoms include fever, swollen lymph nodes, and a rash that forms blisters and then crusts over. The time from exposure to onset of symptoms ranges from five to twenty-one days. The duration of symptoms is typically two to four weeks. There may be mild symptoms, and it may occur without any symptoms being apparent. The classic presentation of fever and muscle pains, followed by swollen glands, with lesions all at the same stage, has not been found to be common to all outbreaks. Cases may be severe, especially in children, pregnant women or people with suppressed immune systems. The disease is caused by the monkeypox virus, a zoonotic virus in the genus ''Orthopoxvirus''. The variola virus, the causative agent of smallpox, is also in this genus. Of the two types in humans, cladeII (formerly West African clade) causes a less severe disease than the Central A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunohistochemistry
Immunohistochemistry (IHC) is the most common application of immunostaining. It involves the process of selectively identifying antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. IHC takes its name from the roots "immuno", in reference to antibodies used in the procedure, and "histo", meaning tissue (compare to immunocytochemistry). Albert Coons conceptualized and first implemented the procedure in 1941. Visualising an antibody-antigen interaction can be accomplished in a number of ways, mainly either of the following: * ''Chromogenic immunohistochemistry'' (CIH), wherein an antibody is conjugated to an enzyme, such as peroxidase (the combination being termed immunoperoxidase), that can catalyse a colour-producing reaction. * '' Immunofluorescence'', where the antibody is tagged to a fluorophore, such as fluorescein or rhodamine. Immunohistochemical staining is widely used in the dia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pediatr Infect Dis J
''The Pediatric Infectious Disease Journal'' is a monthly peer-reviewed medical journal covering research pertaining to infectious diseases in children. It was established in 1982 as a bimonthly journal under the name ''Pediatric Infectious Disease'', obtaining its current name in 1987. It is published by Lippincott Williams & Wilkins and the editors-in-chief are John D. Nelson and George H. McCracken Jr. (University of Texas Southwestern Medical Center). Abstracting and indexing The journal is abstracted and indexed in: *BIOSIS *MEDLINE/PUBMED * EMBASE *SCOPUS * Science Citation Index Expanded *Current Contents/Clinical Medicine According to the ''Journal Citation Reports'', the journal has a 2014 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 2.723. Refe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Umbilication
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment. Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses, as well as many nonpathologic states (like, in certain circumstances, melanonychia and racquet nails). While only a small number of skin diseases account for most visits to the physician, thousands of skin conditions have been described. Classification of these conditions often presents many nosological challenges, since underlying causes and pathogenetics are often not known. Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane), morphology ( chronic blistering conditions), cause (skin conditions result ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pustule
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment. Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses, as well as many nonpathologic states (like, in certain circumstances, melanonychia and racquet nails). While only a small number of skin diseases account for most visits to the physician, thousands of skin conditions have been described. Classification of these conditions often presents many nosological challenges, since underlying causes and pathogenetics are often not known. Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane), morphology ( chronic blistering conditions), cause (skin conditions result ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cutaneous Condition
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment. Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses, as well as many nonpathologic states (like, in certain circumstances, melanonychia and racquet nails). While only a small number of skin diseases account for most visits to the physician, thousands of skin conditions have been described. Classification of these conditions often presents many nosological challenges, since underlying causes and pathogenetics are often not known. Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane), morphology ( chronic blistering conditions), cause (skin conditions result ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Universal Precautions
Universal precautions refers to the practice, in medicine, of avoiding contact with patients' bodily fluids, by means of the wearing of nonporous articles such as medical gloves, goggles, and face shields. The infection control techniques were essentially good hygiene habits, such as hand washing and the use of gloves and other barriers, the correct handling of hypodermic needles, scalpels, and aseptic techniques. Following the AIDS outbreak in the 1980s the US CDC formally introduced them in 1985–88. Every patient was treated as if infected and therefore precautions were taken to minimize risk. In 1987, the practice of universal precautions was adjusted by a set of rules known as body substance isolation. In 1996, both practices were replaced by the latest approach known as standard precautions. Use of personal protective equipment is now recommended in all health care settings. Historical significance Universal precautions are an infection control practice. Under universa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monkeypox In The Democratic Republic Of The Congo
Mpox is endemic in western and central Africa, with the majority of cases occurring in the Democratic Republic of the Congo (DRC), where the disease is reportable. There, the more virulence, virulent Congo basin virus clade, type has been affecting some of the world's poorest and social exclusion, socially excluded communities. Many cases occur sporadically or in small clusters, but large outbreaks also occur. Early cases The world's first case of human mpox was detected in a nine-month old child in 1970 in the Democratic Republic of the Congo (then Zaire), two years after it reported its last case of smallpox. The onset of their rash was on 24 August. That year, the disease was identified in another four children, including three in Liberia who were playmates. At the time, evidence of the virus was found in non-human primates in Liberia and Sierre Leone. Active surveillance by the World Health Organization (WHO) between 1981 and 1986, identified 338 cases with a human-to-human t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New Jersey
New Jersey is a state in the Mid-Atlantic and Northeastern regions of the United States. It is bordered on the north and east by the state of New York; on the east, southeast, and south by the Atlantic Ocean; on the west by the Delaware River and Pennsylvania; and on the southwest by Delaware Bay and the state of Delaware. At , New Jersey is the fifth-smallest state in land area; but with close to 9.3 million residents, it ranks 11th in population and first in population density. The state capital is Trenton, and the most populous city is Newark. With the exception of Warren County, all of the state's 21 counties lie within the combined statistical areas of New York City or Philadelphia. New Jersey was first inhabited by Native Americans for at least 2,800 years, with the Lenape being the dominant group when Europeans arrived in the early 17th century. Dutch and Swedish colonists founded the first European settlements in the state. The British later seized control o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
African Brush-tailed Porcupine
The African brush-tailed porcupine (''Atherurus africanus'') is a species of rat-like Old World porcupine, indigenous to a broad belt of Africa ranging from Guinea on the west coast to Kenya on the east. This is a common species with a very wide range, and despite it being used extensively for bushmeat, the International Union for Conservation of Nature has rated its conservation status as being of "least concern". Description The brush-tailed porcupine reaches 40 to 50 cm in length, not counting the tail. The adult weighs about 3 kg. It has an elongated, rat-like face and body and short legs, tipped with clawed and webbed feet. Unlike most other porcupines, the brush-tailed porcupine has light, small quills. On the tail, these quills are thinner and brush-like. These can make noise when rattled. Distribution The brush-tailed porcupine occurs in Benin, Cameroon, Congo, the Democratic Republic of Congo, Equatorial Guinea, Gabon, Gambia, Ghana, Guinea, Ivory Coast, Kenya ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tree Squirrels
Tree squirrels are the members of the squirrel family (Sciuridae) commonly just referred to as "squirrels." They include more than 100 arboreal species native to all continents except Antarctica and Oceania. They do not form a single natural, or monophyletic, group; they are variously related to others in the squirrel family, including ground squirrels, flying squirrels, marmots, and chipmunks. The defining characteristic used to determine which species of Sciuridae are tree squirrels is dependent on their habitat rather than their physiology. Tree squirrels live mostly among trees, as opposed to those that live in burrows in the ground or among rocks. An exception is the flying squirrel that also makes its home in trees, but has a physiological distinction separating it from its tree squirrel cousins: special flaps of skin called patagia, acting as glider wings, which allow gliding flight. The best known genus of tree squirrels is ''Sciurus'', which includes the eastern gray sq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Accra
Accra (; tw, Nkran; dag, Ankara; gaa, Ga or ''Gaga'') is the capital and largest city of Ghana, located on the southern coast at the Gulf of Guinea, which is part of the Atlantic Ocean. As of 2021 census, the Accra Metropolitan District, , had a population of 284,124 inhabitants, and the larger Greater Accra Region, , had a population of 5,455,692 inhabitants. In common usage, the name "Accra" often refers to the territory of the Accra Metropolitan District as it existed before 2008, when it covered .Sum of the land areas of Accra Metropolitan District, Ablekuma Central Municipal District, Ablekuma North Municipal District, Ablekuma West Municipal District, Ayawaso Central Municipal District, Ayawaso East Municipal District, Ayawaso North Municipal District, Ayawaso West Municipal District, Korle Klottey Municipal District, Krowor Municipal District, La Dadekotopon Municipal District, Ledzokuku Municipal District, and Okaikoi North Municipal District, as per the 2021 ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
