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2-hydroxyglutarate Dehydrogenase
2-hydroxyglutarage dehydrogenase may refer to: * L-2-hydroxyglutarate dehydrogenase, an enzyme specific to L-2-hydroxyglutarate (EC 1.1.99.2) * D-2-hydroxyglutarate dehydrogenase, an enzyme specific to D-2-hydroxyglutarate (EC 1.1.99.39) {{enzyme index ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
L-2-hydroxyglutarate Dehydrogenase
In enzymology, an L-2-hydroxyglutarate dehydrogenase () is an enzyme that catalyzes the chemical reaction :(S)-2-hydroxyglutarate + acceptor \rightleftharpoons 2-oxoglutarate + reduced acceptor Thus, the two substrates of this enzyme are (S)-2-hydroxyglutarate and acceptor, whereas its two products are 2-oxoglutarate and reduced acceptor. Enzymes which preferentially catalyze the conversion of the (R) stereoisomer of 2-oxoglutarate also exist in both mammals and plants and are named D-2-hydroxyglutarate dehydrogenase. L-2-hydroxyglutarate is produced by promiscuous action of malate dehydrogenase on 2-oxoglutarate; L-2-hydroxyglutarate dehydrogenase is an example of a metabolite repair enzyme that oxidizes L-2-hydroxyglutarate back to 2-oxoglutarate. Nomenclature This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-2-hydroxyglutarate:acceptor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |