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1B N2 Locomotives
1B may refer to: Science and technology * Alpha-1B adrenergic receptor * Arginine vasopressin receptor 1B * Interferon beta-1b * Melatonin receptor 1B * The ASCII hexadecimal code for the escape character Sport * First baseman * Single (baseball) Transport * Axle arrangement on steam locomotives corresponding to a 2-4-0 wheel arrangement * GCR Class 1B, a class of British 2-6-4T steam locomotive * National Highway 1B (India, old numbering) See also * B1 (other) B1, B.I, B.1 or B-1 may refer to: Biology and chemistry * Bradykinin receptor B1, a human protein * Cinnamtannin B1, a condensed tannin found in cinnamon * Combretastatin B-1, a stilbenoid found in ''Combretum sp.'' * Fumonisin B1, a toxins pr ... * Billion * * {{Letter-NumberCombDisambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1B Adrenergic Receptor
The alpha-1B adrenergic receptor (α1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. The crystal structure of the α1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin. Receptor There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells. Gene This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. Ligands ; Antagonists * L-765,314 * Risperidone * Brexpiprazole Interactions Alpha-1B adr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arginine Vasopressin Receptor 1B
Vasopressin V1b receptor (V1BR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B is a protein that in humans is encoded by the ''AVPR1B'' (arginine vasopressin receptor 1B) gene. V1BR acts as a receptor for vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. It is a major contributor to homeostasis and the control of water, glucose, and salts in the blood. Arginine vasopressin has four receptors, each of which are located in different tissues and have specific functions. AVPR1b is a g-protein coupled pituitary receptor that has only recently been characterized because of its rarity. It has been found that the 420-amino-acid sequence of the AVPR1B receptor shared the most overall similarities with the AVP1A, AVP2 and oxytocin receptors. AVPR1B maps to chromosome region 1q32 and is a member of the vasopressin/oxytocin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interferon Beta-1b
Interferon beta-1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS). It is approved for use after the first MS event. Closely related is interferon beta 1a, also indicated for MS, with a very similar drug profile. Mechanism of action Interferon beta balances the expression of pro- and anti-inflammatory agents in the brain, and reduces the number of inflammatory cells that cross the blood brain barrier. Overall, therapy with interferon beta leads to a reduction of neuron inflammation. Moreover, it is also thought to increase the production of nerve growth factor and consequently improve neuronal survival. Side effects Interferon beta-1b is available only in injectable forms, and can cause skin reactions at the injection site that may include cutaneous necrosis. Skin reactions vary greatly in their clinical presentation. They usually appear within the first month of treatment albeit their freque ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Melatonin Receptor 1B
Melatonin receptor 1B, also known as MTNR1B, is a protein that in humans is encoded by the ''MTNR1B'' gene. Function This gene encodes the MT2 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain; however, this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. Besides the brain and retina this receptor is expressed on the bone forming cells where it regulates their function in depositing bone. Clinical significance Several studies have identified MTNR1B receptor mutations that are associated with increased average blood sugar level and around a 20 percent elevated risk of developing type 2 diabetes.; ; ; ; MTNR1B mRNA is expressed in human islet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Escape Character
In computing and telecommunication, an escape character is a character (computing), character that invokes an alternative interpretation on the following characters in a character sequence. An escape character is a particular case of metacharacters. Generally, the judgement of whether something is an escape character or not depends on the context. In the telecommunication Telecommunication is the transmission of information by various types of technologies over wire, radio, optical, or other electromagnetic systems. It has its origin in the desire of humans for communication over a distance greater than that fe ...s field, escape characters are used to indicate that the following characters are encoded differently. This is used to alter control characters that would otherwise be noticed and acted on by the underlying telecommunications hardware. In this context, the use of escape characters is often referred to as quoting. Definition An escape character may not have its o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
First Baseman
A first baseman, abbreviated 1B, is the player on a baseball or softball team who fields the area nearest first base, the first of four bases a baserunner must touch in succession to score a run. The first baseman is responsible for the majority of plays made at that base. In the numbering system used to record defensive plays, the first baseman is assigned the number 3. Also called first sacker or cornerman, the first baseman is ideally a tall player who throws left-handed and possesses good flexibility and quick reflexes. Flexibility is needed because the first baseman receives throws from the other infielders, the catcher and the pitcher after they have fielded ground balls. In order for the runner to be called out, the first baseman must be able to ''stretch'' towards the throw and catch it before the runner reaches first base. First base is often referred to as "the other hot corner"—the "hot corner" being third baseman, third base—and therefore, like the third baseman ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single (baseball)
In baseball, a single is the most common type of base hit, accomplished through the act of a batter safely reaching first base by hitting a fair ball (thus becoming a runner) and getting to first base before a fielder puts him out. As an exception, a batter-runner reaching first base safely is not credited with a single when an infielder attempts to put out another runner on the first play; this is one type of a fielder's choice. Also, a batter-runner reaching first base on a play due to a fielder's error trying to put him out at first base or another runner out (as a fielder's choice) is not credited with a single. On a single hit to the outfield, any runners on second base or third base normally score, and sometimes the runner from first base is able to advance to third base. Depending on the location of the hit, a quick recovery by the outfielder can prevent such an advance or create a play on the advancing runner. Hitters who focus on hitting singles rather than doubles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Axle Arrangement
In rail transport, a wheel arrangement or wheel configuration is a system of classifying the way in which wheels are distributed under a locomotive. Several notations exist to describe the wheel assemblies of a locomotive by type, position, and connections, with the adopted notations varying by country. Within a given country, different notations may also be employed for different kinds of locomotives, such as steam, electric, and diesel powered. Especially in steam days, wheel arrangement was an important attribute of a locomotive because there were many different types of layout adopted, each wheel being optimised for a different use (often with only some being actually "driven"). Modern diesel and electric locomotives are much more uniform, usually with all axles driven. Major notation schemes The main notations are the Whyte notation (based on counting the wheels), the AAR wheel arrangement notation (based on counting either the axles or the bogies), and the UIC classificat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GCR Class 1B
The GCR Class 1B was a class of 2-6-4T (tank) locomotives on the Great Central Railway. They were notable as the first locomotives of the 2-6-4T (or ''Adriatic'') wheel arrangement to be used by a British standard-gauge railway; there had been two narrow-gauge examples on the Leek & Manifold Valley Light Railway since 1904. History In 1906, the Great Central Railway (GCR) had inherited nine 0-6-4T locomotives from the Lancashire, Derbyshire and East Coast Railway (LD&EC), of class D (LNER class M1). These had been designed to the specifications of Robert A. Thom, the locomotive superintendent of the LD&EC, for hauling coal trains from northern Derbyshire and Nottinghamshire to the docks at Grimsby. They were built by Kitson & Co in 1904 and 1906, and performed well. When further locomotives were required for similar duties, opportunity was taken to produce an updated design. The 1B class locomotives were designed by the GCR's locomotive superintendent John G. Robinson, wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Highway 1B (India, Old Numbering)
National Highway 1B (NH 1B) was an Indian National Highway entirely within the union territory of Jammu and Kashmir. NH 1B linked Batote with Khanbal and is long. It has been renamed as National Highway 244. Route * Doda * Kistwar * Sinthan pass * Hemis pass See also * List of National Highways in India (by Highway Number) * List of National Highways in India * National Highways Development Project The National Highways Development Project (NHDP) is a project to upgrade, rehabilitate and widen major highways in India to a higher standard. The project was started in 1998 under the leadership of Prime Minister, Atal Bihari Vajpayee. Natio ... References External links NH 1B on OpenStreetMap 1B National highways in India (old numbering) {{India-NH-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
B1 (other)
B1, B.I, B.1 or B-1 may refer to: Biology and chemistry * Bradykinin receptor B1, a human protein * Cinnamtannin B1, a condensed tannin found in cinnamon * Combretastatin B-1, a stilbenoid found in ''Combretum sp.'' * Fumonisin B1, a toxins produced by several species of ''Fusarium'' molds * B-1 cell, a lymphocyte type * Arecatannin B1, a tannin found in the betel nut * Proanthocyanidin B1, a B type proanthocyanidin * Vitamin B1, also known as thiamine Media * B1 TV, a Romanian TV network * A class of FM radio broadcasting in North America Roads Vehicles * Rockwell B-1 Lancer, a United States Air Force strategic bomber * B1 (New York City bus) serving Brooklyn * B1 type submarine, a World War II Imperial Japanese Navy submarine class * Alsace-Lorraine B 1, an Alsace-Lorraine P 1 class steam locomotive * Marussia B1, a high-performance luxury sports coupé built by Russian automaker Marussia Motors * GS&WR Class B1, a Great Southern and Western Railway Irish ste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
